1974
DOI: 10.1212/wnl.24.5.401
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Carbamazepine for epilepsy

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Cited by 179 publications
(51 citation statements)
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“…Carbamazepine reduced the frequency of complex partial seizures by 83% and of generalized tonic-clonic seizures by 55%, compared with placebo. Cereghino et al (1974) compared monotherapy with carbamazepine (1,200 mgiday), phenytoin (300 mg/day), and phenobarbital (300 mgiday) in 45 institutionalized patients with chronic epilepsy, using a double-blind, Latin square experimental design. The patients received their regular drug therapy for 2 weeks between each of the 3-week test periods.…”
Section: M Trezmanmentioning
confidence: 99%
“…Carbamazepine reduced the frequency of complex partial seizures by 83% and of generalized tonic-clonic seizures by 55%, compared with placebo. Cereghino et al (1974) compared monotherapy with carbamazepine (1,200 mgiday), phenytoin (300 mg/day), and phenobarbital (300 mgiday) in 45 institutionalized patients with chronic epilepsy, using a double-blind, Latin square experimental design. The patients received their regular drug therapy for 2 weeks between each of the 3-week test periods.…”
Section: M Trezmanmentioning
confidence: 99%
“…This concerns the fact that in the preclinical mouse model of AT deficiency, used for evaluating the CBZ effects, the results have been obtained with doses of the drug significantly higher than the doses used in humans (200 mg/kg/day vs. 10-20 mg/kg/day), lower doses of CBZ have not been effective, and in the study, the plasma levels of CBZ have not been evaluated [1,2]. However, it is worth noting that as stated by Hidvegi et al in the discussion section of their paper [2], ''Effective doses of drugs can be 10-to 20-fold higher in mice because of the higher ratio of surface area to weight when compared to humans'', and that the findings from preclinical and clinical studies exemplified in Table 1 fit this statement. CBZ is a safe drug with a wide clinical spectrum of action which ranges from epileptic seizures to cerebellar tremors and myotonia [3][4][5], with well-known plasma therapeutic levels in each of these pathologies [3][4][5]. In particular, an analysis of the relationship between CBZ doses per body weight, necessary for clinical effects and CBZ plasma levels, indicates that in humans severe neurological and cardiovascular effects are usually seen at CBZ daily doses higher than 20 mg/kg, and at plasma CBZ levels greater than 12 lg/ml [6,7].…”
Section: To the Editormentioning
confidence: 99%
“…At present, the determination of plasma CBZ levels is a routinary and rather easy task both in clinical and experimental settings [3][4][5], and further studies on the therapeutic plasma levels of CBZ in preclinical animal models of AT deficiency could help to improve the quality of clinical trials aimed at assessing the efficacy of CBZ in patients with liver disease as a result of AT deficiency.…”
Section: To the Editormentioning
confidence: 99%
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“…Carbamazepine (CBZ) is a major antiepileptic agent and its clinical efficacy has been stressed by several authors (Cereghino, Brock, van Meter, Penry, Smith & White, 1974;Dalby, 1971;Monaco, Riccio, Benna, Covacich, Durelli, Fantini, Furlan, Gilli, Mutani, Troni, Gerna & Morselli, 1976;Rodin, Rim & Rennick, 1974;Troupin, Green & Levy, 1974). The pharmacokinetics and the metabolism of the drug have been extensively described in both experimental animals and man (Farghali-Hassan, Assael, Bossi, Gerna, Garattini, Gomeni & Morselli, 1976;Levy, Lockard, Green, Friel & Martis, 1975;Levy Pitlick, Troupin, Green & Neal, 1975;Morselli, 1975;Morselli, Gerna & Garattini, 1971;.…”
Section: Introductionmentioning
confidence: 99%