Carbohydrate derivative-functionalized biosensing toward highly sensitive electrochemical detection of cell surface glycan expression as cancer biomarker

Zhang, Xinai; Lu, Wenjie; Shen, Jianzhong; Jiang, Yuxiang; Han, En‐Hou; Dong, Xiaopeng; Huang, Jiana

doi:10.1016/j.bios.2015.06.051

Cited by 28 publications

(13 citation statements)

References 41 publications

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“…In addition, glycosyls on the cell surface play an important role in cell recognition, adhesion, immune response, and the occurrence and migration of cancer cells . Therefore, the cell electrochemical sensor based on surface‐specific glycosyls of cancer cells has also successfully achieved the specific recognition and linear detection of HeLa cells, polysaccharide‐rich K562 leukemia cells, and MDA‐MB‐231 cells …”

Section: Electrochemical Immunosensors In Tumor Cell Detectionmentioning

confidence: 99%

“…[42][43][44] Therefore, the cell electrochemical sensor based on surface-specific glycosyls of cancer cells has also successfully achieved the specific recognition and linear detection of HeLa cells, polysaccharide-rich K562 leukemia cells, and MDA-MB-231 cells. 14,[45][46][47][48] Folic acid (FA) receptor is a cell surface receptor that is excessively expressed on most human tumor cells and rarely expressed or not at all in normal organs. Therefore, FA is often used as a target for antitumor drugs.…”

Section: Electrochemical Immunosensors In Tumor Cell Detectionmentioning

confidence: 99%

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Application of electrochemical biosensors in tumor cell detection

Zhang

et al. 2020

Thoracic Cancer

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Conventional methods for detecting tumors, such as immunological methods and histopathological diagnostic techniques, often request high analytical costs, complex operation, long turnaround time, experienced personnel and high false‐positive rates. In addition, these assays are difficult to obtain an early diagnosis and prognosis quickly for malignant tumors. Compared with traditional technology, electrochemical technology has realized the study of interface charge transfer behavior at the atomic and molecular levels, which has become an important analytical and detection tool in contemporary analytical science. Electrochemical technique has the advantages of rapid detection, high sensitivity (single cell) and specificity in the detection of tumor cells, which has not only been successful in differentiating tumor cells from normal cells, but has also achieved targeted detection of localized tumor cells and circulating tumor cells. Electrochemical biosensors provide powerful tools for early diagnosis, staging and prognosis of tumors in clinical medicine. Therefore, this review mainly discusses the development and application of electrochemical biosensors in tumor cell detection in recent years.

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Section: Electrochemical Immunosensors In Tumor Cell Detectionmentioning

confidence: 99%

Section: Electrochemical Immunosensors In Tumor Cell Detectionmentioning

confidence: 99%

Application of electrochemical biosensors in tumor cell detection

Zhang

et al. 2020

Thoracic Cancer

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“…CNTs can be used as a scaffold for preparing signaling labels because of their high surface area-to-volume ratio. Glycan expression on cancer cells was detected by using MWCNT labels modified with HRP and lectin concanavalin A (Con A) [ 86 ] ( Figure 8 ). The MWCNT label was prepared by covalently modifying the surface of carboxylated MWCNTs after carbodiimide activation.…”

Section: Carbon Nanotube-based Biosensors For Cancer Biomarkersmentioning

confidence: 99%

Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review

2017

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This article reviews recent progress in the development of nanomaterial-based electrochemical biosensors for cancer biomarkers. Because of their high electrical conductivity, high affinity to biomolecules, and high surface area-to-weight ratios, nanomaterials, including metal nanoparticles, carbon nanotubes, and graphene, have been used for fabricating electrochemical biosensors. Electrodes are often coated with nanomaterials to increase the effective surface area of the electrodes and immobilize a large number of biomolecules such as enzymes and antibodies. Alternatively, nanomaterials are used as signaling labels for increasing the output signals of cancer biomarker sensors, in which nanomaterials are conjugated with secondary antibodies and redox compounds. According to this strategy, a variety of biosensors have been developed for detecting cancer biomarkers. Recent studies show that using nanomaterials is highly advantageous in preparing high-performance biosensors for detecting lower levels of cancer biomarkers. This review focuses mainly on the protocols for using nanomaterials to construct cancer biomarker sensors and the performance characteristics of the sensors. Recent trends in the development of cancer biomarker sensors are discussed according to the nanomaterials used.

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“…This sensor can be used for detecting hCG in urine samples from pregnant women. Multi-wall CNTs have also been used as a component of biosensors that detect cell surface glycan expression as cancer biomarkers [31]. …”

Section: Immunosensors For Glycoproteinsmentioning

confidence: 99%

Recent Progress in Electrochemical Biosensors for Glycoproteins

Akiba

Anzai

2016

Sensors

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This review provides an overview of recent progress in the development of electrochemical biosensors for glycoproteins. Electrochemical glycoprotein sensors are constructed by combining metal and carbon electrodes with glycoprotein-selective binding elements including antibodies, lectin, phenylboronic acid and molecularly imprinted polymers. A recent trend in the preparation of glycoprotein sensors is the successful use of nanomaterials such as graphene, carbon nanotube, and metal nanoparticles. These nanomaterials are extremely useful for improving the sensitivity of glycoprotein sensors. This review focuses mainly on the protocols for the preparation of glycoprotein sensors and the materials used. Recent improvements in glycoprotein sensors are discussed by grouping the sensors into several categories based on the materials used as recognition elements.

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Carbohydrate derivative-functionalized biosensing toward highly sensitive electrochemical detection of cell surface glycan expression as cancer biomarker

Cited by 28 publications

References 41 publications

Application of electrochemical biosensors in tumor cell detection

Application of electrochemical biosensors in tumor cell detection

Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review

Recent Progress in Electrochemical Biosensors for Glycoproteins

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