“…The alpha-glucosidase inhibitors (1) have no significant effect on total caloric intake, 22 (2) delay and decrease carbohydrate absorption, [23][24][25][26][27] (3) have not been directly evaluated for HGU, (4) have negligible effect on hepatic glucose output, 28,29 (5) reduce IR, 22,[30][31][32][33] (6) have variable effects on PGU, 22,28,30,[34][35][36][37][38] and (7) reduce plasma insulin concentrations. 22,[39][40][41][42][43][44][45] Studies meeting the review criteria for the target effects of the alpha-glucosidase inhibitors on the respective targets are summarized here.…”