Carbohydrate Metabolism in Two Forms of Hyperglyceridemia *

Knittle, Jerome L.; Ahrens, E. H.

doi:10.1172/jci104934

Cited by 127 publications

(24 citation statements)

References 18 publications

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“…The direct correlation between smoking and serum cholesterol does suggest a mechanism to e q l a i n partiaiiy the observations relating cigarette smoking to the degree o f coronary arteriolsclerosis (29) and to the development o f myocardial infarction (30). Of Obesity and abnormal carbohydrate tolerance occur together frequently and both have been reported i n association with high plasma triglyceride levels (33,34). In spite o f their frequent coincidence, these characteristics correlate independently with the Sf 20-400 lipoproteins.…”

mentioning

confidence: 99%

Constitutional and Environmental Factors Related to Serum Lipid and Lipoprotein Levels

Harlan

Oberman²,

Mitchell³

et al. 1967

Ann Intern Med

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lipoproteins were related to acquired obesity, carbohydm te tolerance, and "aggressiveness" and I'sociability'' as determined by personality survey. Carbohydrate tolernnce, obesity, and personality were apparently independent variables. Serum triglyceride levels correlated with the same variables as the S f 20-400 lipoproteins; serum cholesterol levels were related to factors that correlated with both lipoprotein gmups. High levels (above 90th percentile) o f each lipoprotein fraction and each lipid were associated with significantly greater quantities o f h e variables found to be correlated with each lipid fraction. The prevalence of familial hyperlipidemias was low (approximately 3-4%), but 18 per cent of individuals with elevated cholesterol and a high risk o f coronary heart disease could be tentatively classified as having a type of familial hyperlipidemia. ACKNOWLEDGMENTS

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mentioning

confidence: 99%

Constitutional and Environmental Factors Related to Serum Lipid and Lipoprotein Levels

Harlan

Oberman²,

Mitchell³

et al. 1967

Ann Intern Med

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“…Underlying mechanisms for increased plasma VLDL are poorly understood. Some investigators have postulated that overproduction of VLDL is the predominant mechanism (1-5) while others have concluded that defective VLDL removal or degradation is of more importance (6)(7)(8)(9)(10). Most likely hypertriglyceridemia is heterogeneous in its pathogenesis, but at the moment there are uncertainties that preclude any final assessment.…”

mentioning

confidence: 99%

Transport of Very Low Density Lipoprotein Triglycerides in Varying Degrees of Obesity and Hypertriglyceridemia

Grundy¹,

Mok²,

Zech³

et al. 1979

J. Clin. Invest.

271

107

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A B S T R A C T Measurements oftransport oftriglycerides (TG) in very low density lipoproteins (VLDL) were carried out in 59 patients by injection of radioactive glycerol, determinations of specific activities of VLDL-TG for 48 h thereafter, and treatment of the data by multicompartmental analysis. The patients were divided into three groups: normal weight (89-120% ideal weight), mildly obese (120-135% ideal weight), and markedly obese (135% ideal weight). They had varying levels of VLDL-TG ranging from normal to markedly elevated. In many subjects, there was a positive correlation between concentrations and transport of VLDL indicating that overproduction of VLDL-TG contributed to hypertriglyceridemia. In others, and particularly in several markedly obese subjects, transport rates were greatly increased without significant hypertriglyceridemia, suggesting that they had enhanced capacity to clear TG. In all groups, however, there were patients whose degree ofhypertriglyceridemia seemed out of proportion to their transport rates. This finding and the fact that many patients have increased secretion ofVLDL-TG without elevated plasma TG suggests that both overproduction of VLDL-TG and insufficient enhancement of clearance contributed to the development of hypertriglyceridemia.The data showed a poor correlation between transport rates determined by our multicompartment analysis and single-exponential analysis used previously by other investigators (r = 0.46); this comparison was not improved by segregating patients according to their degree of obesity. Although two conversion pathways (fast and slow synthetic paths) were required to fit the data, there was no correlation between transport ratesThis work was presented, in part, at the 49th and 50th

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“…It remains to be determined whether it reflects a different basis for the hypertriglyceridemia in the two patients. DISCUSSION It has long been appreciated that fat-free high carbohydrate diets cause a marked elevation in plasma triglycerides (1)(2)(3)(4)(5). The data presented here suggest that this rise is usually due to the apparence in plasma of both greater numbers of VLDL particles and of particles that are larger and relatively richer in triglyceride than those found in the basal state.…”

Section: Electron Microscopic Studiesmentioning

confidence: 54%

“…High carbohydrate low fat diets increase the concentration of plasma triglycerides in both normal and hypertriglyceridemic subjects (1)(2)(3)(4)(5). According to current theory, these diets cause protracted elevations of blood glucose and insulin (5-7) which in turn lead to an increased synthesis and release of triglyceride-rich very low density lipoproteins (VLDL)l by the liver (5, 6, 8-10).…”

Section: Introductionmentioning

confidence: 99%

A biochemical and morphologic study of very low density lipoproteins in carbohydrate-induced hypertriglyceridemia

Ruderman¹,

Jones²,

Krauss³

et al. 1971

J. Clin. Invest.

133

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Carbohydrate Metabolism in Two Forms of Hyperglyceridemia *

Cited by 127 publications

References 18 publications

Constitutional and Environmental Factors Related to Serum Lipid and Lipoprotein Levels

Constitutional and Environmental Factors Related to Serum Lipid and Lipoprotein Levels

Transport of Very Low Density Lipoprotein Triglycerides in Varying Degrees of Obesity and Hypertriglyceridemia

A biochemical and morphologic study of very low density lipoproteins in carbohydrate-induced hypertriglyceridemia

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