“…The final product of the pyridoxal 5′-phosphate biosynthesis I pathway, pyridoxal 5′-phosphate (PLP), is the active form of vitamin B 6 (pyridoxine), which serves as a cofactor for essential enzymes involved in the metabolism of macronutrients such as carbohydrates, amino acids, and lipids ( 22 ). The glucose degradation (oxidative) pathway converts d -glucopyranose, a ring form of glucose, into d -gluconate 6-phosphate before producing pyruvate, which is required for the tricarboxylic acid (TCA) cycle ( 23 ). The polymyxin resistance pathway produces a lipopolysaccharide (LPS) called 4′-α- l -Ara4N-α-Kdo-(2→4)-α-Kdo-(2→6)-[P4′-α- l -ara4N]-lipid A from 4-amino-4-deoxy- l -arabinopyranose ( 24 ).…”