Carbohydrate polymer-based nanoparticle application in drug delivery for CNS-related disorders

Ansari, Ramin; Sadati, Seyed Mahdi; Mozafari, Negin; Ashrafi, Hajar; Azadi, Amir

doi:10.1016/j.eurpolymj.2020.109607

Cited by 48 publications

(20 citation statements)

References 90 publications

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“…The most common procedures for preparing CH-based NPs are, emulsion based solvent evaporation, ionotropic gelation, solvent diffusion, emulsification, as well as the microemulsion method ( Garg et al., 2019 ; Zhang et al., 2019 ; Ansari et al., 2020 ). Some of the benefits associated with the above techniques include the use of less organic solvent and the need for a lower force.…”

Section: Preparation Of Ch Npsmentioning

confidence: 99%

Chitosan-Based Nanoparticles Against Viral Infections

Boroumand

Badie

Mazaheri

et al. 2021

Front. Cell. Infect. Microbiol.

111

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Viral infections, in addition to damaging host cells, can compromise the host immune system, leading to frequent relapse or long-term persistence. Viruses have the capacity to destroy the host cell while liberating their own RNA or DNA in order to replicate within additional host cells. The viral life cycle makes it challenging to develop anti-viral drugs. Nanotechnology-based approaches have been suggested to deal effectively with viral diseases, and overcome some limitations of anti-viral drugs. Nanotechnology has enabled scientists to overcome the challenges of solubility and toxicity of anti-viral drugs, and can enhance their selectivity towards viruses and virally infected cells, while preserving healthy host cells. Chitosan is a naturally occurring polymer that has been used to construct nanoparticles (NPs), which are biocompatible, biodegradable, less toxic, easy to prepare, and can function as effective drug delivery systems (DDSs). Furthermore, chitosan is Generally Recognized as Safe (GRAS) by the US Food and Drug Administration (U.S. FDA). Chitosan NPs have been used in drug delivery by the oral, ocular, pulmonary, nasal, mucosal, buccal, or vaginal routes. They have also been studied for gene delivery, vaccine delivery, and advanced cancer therapy. Multiple lines of evidence suggest that chitosan NPs could be used as new therapeutic tools against viral infections. In this review we summarize reports concerning the therapeutic potential of chitosan NPs against various viral infections.

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Section: Preparation Of Ch Npsmentioning

confidence: 99%

Chitosan-Based Nanoparticles Against Viral Infections

Boroumand

Badie

Mazaheri

et al. 2021

Front. Cell. Infect. Microbiol.

111

View full text Add to dashboard Cite

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“…Chitosan nanoparticles administered in the nasal pathway have also been investigated for Alzheimer’s disease; loading them with various active moieties, such as insulin [ 129 ], galantamine (where a decrease in acetylcholinesterase is observed), and piperine (a potential neuroprotective compound in Alzheimer’s) resulted in a continuous release from the nanoparticles [ 128 ]. Chitosan-based nanoparticles for intranasal administration have also been investigated for other diseases, including spinal heart injuries (methylprednisone) and cerebral ischemia (rutine) [ 129 ].…”

Section: Chitosan-based Formulations For Intranasal Administrationmentioning

confidence: 99%

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Popescu

Ghica

Dinu-Pîrvu

et al. 2020

IJMS

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In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

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“…The use of nanoparticulated drug delivery systems has gained interest in the last decades due to the possibility of control the rate and period of drug delivery [ 1 , 2 ]. These nanoparticulated materials has as an advantage the increase of bioavailability, solubility, and permeability of different drugs molecules that are otherwise difficult to deliver orally [ 3 , 4 , 5 ]. Indeed, the development of polymeric nanoparticles containing therapeutic agents has attracted considerable interest in scientific and commercial fields due to their capability to efficiently control drug release and improve the specificity with the target site, while protecting therapeutic molecules from degradation activities.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, the development of polymeric nanoparticles containing therapeutic agents has attracted considerable interest in scientific and commercial fields due to their capability to efficiently control drug release and improve the specificity with the target site, while protecting therapeutic molecules from degradation activities. In addition, the nanoparticulated delivery systems are more efficient in avoiding undesired side effects (i.e., allergic reactions, stomach ulcers, kidney and liver problems), when compared to conventional formulation [ 4 , 5 , 6 ]. In addition, the possibility of preparation of polymeric nanoparticles using the self-assembly methodology is quite interesting since it comprises a cost-effective and versatile process for the production of stable and robust structures [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

et al. 2021

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This investigation focuses on the development and optimization of cashew gum polysaccharide (CGP) nanoparticles grafted with polypropylene glycol (PPG) as carriers for diclofenac sodium. The optimization of parameters affecting nanoparticles formulation was performed using a central composite rotatable design (CCRD). It was demonstrated that the best formulation was achieved when 10 mg of CGP was mixed with 10 μL of PPG and homogenized at 22,000 rpm for 15 min. The physicochemical characterization evidenced that diclofenac was efficiently entrapped, as increases in the thermal stability of the drug were observed. The CGP-PPG@diclofenac nanoparticles showed a globular shape, with smooth surfaces, a hydrodynamic diameter around 275 nm, a polydispersity index (PDI) of 0.342, and a zeta potential of −5.98 mV. The kinetic studies evidenced that diclofenac release followed an anomalous transport mechanism, with a sustained release up to 68 h. These results indicated that CGP-PPG nanoparticles are an effective material for the loading/release of drugs with similar structures to diclofenac sodium.

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Carbohydrate polymer-based nanoparticle application in drug delivery for CNS-related disorders

Cited by 48 publications

References 90 publications

Chitosan-Based Nanoparticles Against Viral Infections

Chitosan-Based Nanoparticles Against Viral Infections

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

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