Carbon-14 urea breath test: does it work in patients with partial gastric resection?

Dede, Fuat; Civen, Hüseyin; Dane, Faysal; Aliustaoğlu, Mehmet; Turhal, Serdar; Turoğlu, Halil Turgut; İnanır, Sabahat

doi:10.1007/s12149-015-1005-3

Cited by 4 publications

(3 citation statements)

References 30 publications

(38 reference statements)

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“…The best results were obtained when the breath samples were collected after 20 minutes and the threshold established > 35 counts per minute (CPM). 46 New tests were also developed: 1, the ammonia breath test showed different breath ammonia levels at baseline and after urea ingestion in 10 of the 14 H. pylori positive patients. Such tests could represent lower cost, 47 and 2, a new point-contact nanosensor device using salts of the organic conductor tetracyanoquinodimethane was assessed and could be used in a portable breath analyzer.…”

Section: Molecular Methodsmentioning

confidence: 99%

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Diagnostic of Helicobacter pylori infection

et al. 2016

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There is progress in endoscopy techniques. While it is not yet possible to detect Helicobacter pylori directly in the stomach, it becomes easier to detect the mucosal changes induced by the bacteria. Some small changes can also increase the sensitivity of the invasive tests, for example culture or histology, but the wide use of proton-pump inhibitors has a negative impact on these tests. Only molecular methods are able to detect a limited load of bacteria, especially by using real-time PCR but also with new methods, for example dual-priming oligonucleotide-based PCR, loop-medicated isothermal amplification, droplet-digital PCR or a multiple genetic analysis system. Among the noninvasive tests, urea breath test remains a test of major interest, while there are attempts to develop an ammonia breath test and other nanosensor devices. A new antigen stool test, a chemoluminescence immunoassay using the LIAISON apparatus has also been tested for the first time with success. Despite its limitations, serology remains the most popular test to detect H. pylori antibodies. It also allows pepsinogen dosage which is of interest for detecting atrophy.

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Section: Molecular Methodsmentioning

confidence: 99%

“…Another study used the 14 C‐UBT in such patients. The best results were obtained when the breath samples were collected after 20 minutes and the threshold established > 35 counts per minute (CPM) …”

Section: Noninvasive Testsmentioning

confidence: 99%

Diagnostic of Helicobacter pylori infection

et al. 2016

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“…Previous research has shown that the 14‐C urea breath test has a sensitivity of 0.96 and a specificity of 0.93; therefore, it remains the main method of H. pylori detection. The 14‐C urea breath test has high sensitivity and accuracy for patients’ status post‐partial gastrectomy …”

Section: Discussionmentioning

confidence: 99%

Relationship between Helicobacter pylori infection and vomiting induced by gastrointestinal cancer chemotherapy

Yao

et al. 2017

Internal Medicine Journal

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Non-invasive diagnostic tests forHelicobacter pyloriinfection

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Takwoingi

Siddique

et al. 2018

Cochrane Database of Systematic Reviews

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In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.

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Carbon-14 urea breath test: does it work in patients with partial gastric resection?

Abstract: The sensitivity of the standard C-14 UBT was very poor for patients with PGR, and results of HpSAT were superior in this population. Certain modifications are needed if C-14 UBT is to be used in PGR patients.

Cited by 4 publications

References 30 publications

Diagnostic of Helicobacter pylori infection

Diagnostic of Helicobacter pylori infection

Relationship between Helicobacter pylori infection and vomiting induced by gastrointestinal cancer chemotherapy

Non-invasive diagnostic tests forHelicobacter pyloriinfection

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