Carbon Dioxide as a Microbial Toxicity Enhancer of Some Antibacterial Agents: A New Potential Water Purification Tool

Martirosyan, Varsik; Hovnanyan, Karlen; Ayrapetyan, Sinerik

doi:10.5402/2012/906761

Cited by 9 publications

(19 citation statements)

References 23 publications

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“…The increase in the lethality of Cl 2 solutions against E. coli and L. monocytogenes with the incorporation of CO 2 MNBs compared to the other gases can be attributed to the ability of CO 2 to form carbonic acid in aqueous solutions and thus increasing the ability of AMs to penetrate through the bacterial cell membranes (Martirosyan et al . 2012). Martirosyan et al .…”

Section: Discussionmentioning

confidence: 99%

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Impact of gas micro‐nano‐bubbles on the efficacy of commonly used antimicrobials in the food industry

et al. 2020

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Aim To study the impact of incorporating micro‐nano‐bubbles (MNBs) in commonly used food antimicrobials (AMs) against Escherichia coli O157:H7 (EC) and Listeria monocytogenes (LM). Methods and Results Air, carbon dioxide (CO2) and nitrogen (N2) were used to incorporate MNBs in city water. AM solution (with or without MNBs) of 9 ml was individually taken into sterile test tubes and mixed with 1 ml of inoculum grown in brain heart infusion (BHI) broth to get the net AM concentrations of 28·4 ppm peracetic acid (PAA), 200 ppm chlorine (Cl2), 5·4% citric acid (CA) and 4·5% lactic acid (LA). After treatment time of 1·5 and 3·0 min, 1 ml of sample was neutralized using Dey–Engley neutralizing broth and plated on BHI agar. For EC, Cl2‐CO2 solutions resulted in significantly greater log reductions (5·2 logs) compared to that of Cl2 solutions without MNBs (3·8 logs). For LM, PAA‐CO2 solutions resulted in significantly greater log reductions (4·4 logs) compared to that of PAA solutions without MNBs (1·7 logs). Conclusions This study demonstrated that the efficacy of Cl2 and PAA AM solutions could be increased by incorporating CO2‐MNBs against EC and LM in microbiological growth medium. Significance and Impact of the Study Incorporation of CO2‐MNBs in AM solutions could increase the efficacy of AMs against pathogens on/in food matrices, which should be tested in future research.

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Section: Discussionmentioning

confidence: 99%

“…Martirosyan et al . (2012) used CO 2 along with calcium hypochlorite against E. coli and concluded that CO 2 could penetrate the microbial cells easily, thus increasing the sensitivity of microbes to the toxic effect of calcium hypochlorite. Sikin et al .…”

Section: Discussionmentioning

confidence: 99%

Impact of gas micro‐nano‐bubbles on the efficacy of commonly used antimicrobials in the food industry

et al. 2020

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“…Moist, warm CO 2 gas could become a competitive disinfection technology. Carbon dioxide gas is an antiviral, antibacterial, and anti-infection agent effective not only on solid surfaces but also in aqueous solutions and water treatment settings (17). Heated, un-pressurized carbon dioxide bubbled through wastewater or aqueous media effectively destroys both waterborne bacteria and viruses (18).…”

Section: Universal Virucidal and Antimicrobial Activitymentioning

confidence: 99%

“…Supercritical CO 2 offers a novel, user-friendly process to sterilize acellular tissue, such as lung matrices, for use in tissue and organ engineering (22). CO 2 can also enhance the effect of some other antibacterial agents, further improving the protection imparted (17). When breathing is impaired, CO 2 -levels in the human body drop, which creates a favorable environment for bacterial growth and a higher risk of infection.…”

Section: Universal Virucidal and Antimicrobial Activitymentioning

confidence: 99%

Humidified Warmed CO2 Treatment Therapy Strategies Can Save Lives With Mitigation and Suppression of SARS-CoV-2 Infection: An Evidence Review

et al. 2020

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The coronavirus disease (COVID-19) outbreak has presented enormous challenges for healthcare, societal, and economic systems worldwide. There is an urgent global need for a universal vaccine to cover all SARS-CoV-2 mutant strains to stop the current COVID-19 pandemic and the threat of an inevitable second wave of coronavirus. Carbon dioxide is safe and superior antimicrobial, which suggests it should be effective against coronaviruses and mutants thereof. Depending on the therapeutic regime, CO2 could also ameliorate other COVID-19 symptoms as it has also been reported to have antioxidant, anti-inflammation, anti-cytokine effects, and to stimulate the human immune system. Moreover, CO2 has beneficial effects on respiratory physiology, cardiovascular health, and human nervous systems. This article reviews the rationale of early treatment by inhaling safe doses of warmed humidified CO2 gas, either alone or as a carrier gas to deliver other inhaled drugs may help save lives by suppressing SARS-CoV-2 infections and excessive inflammatory responses. We suggest testing this somewhat counter-intuitive, but low tech and safe intervention for its suitability as a preventive measure and treatment against COVID-19. Overall, development and evaluation of this therapy now may provide a safe and economical tool for use not only during the current pandemic but also for any future outbreaks of respiratory diseases and related conditions.

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“…Carbon dioxide (CO 2 ) is a basic biogas and has been used for clinical purposes for over a century due to its unique properties [ 4 ]. CO 2 can also enhance the effect of some other germ-destroying agents which further improves the protection imparted [ 5 ]. Irving Langmuir first coined the term ‘plasma’ in 1927 to describe an ionized gas [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Methodical Approach to Inactivate Any Microbial Element like SARS-CoV2

Majumdar¹,

Neogi²,

Dutta

et al. 2022

Natl. Acad. Sci. Lett.

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The proposed paper discusses Far UVC could assassinate microbes without harming healthy tissues. The plasma ion generation will increase the ion (O 2 − ) generation in abundance along with hydrogen ion (H + ), and at the same time, the negative hydroxyl radical (OH − ) formed will merge with the positive (H + ) ion of the virus to break the structure of it. The silver nanoparticle which is present in the diffuser with thermostat support is very effective for destroying the microbial elements by heating the gel present within the diffuser. The gel will mix in the environment, and it will also increase the activity of T cell generation and act as an immunoglobulin booster in the human body while inhaling it. In the proposed device, we are using warm humidified CO 2 strategic therapy in low dose which is able to suppress any microbial element like SARS-CoV2.

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Carbon Dioxide as a Microbial Toxicity Enhancer of Some Antibacterial Agents: A New Potential Water Purification Tool

Cited by 9 publications

References 23 publications

Impact of gas micro‐nano‐bubbles on the efficacy of commonly used antimicrobials in the food industry

Impact of gas micro‐nano‐bubbles on the efficacy of commonly used antimicrobials in the food industry

Humidified Warmed CO2 Treatment Therapy Strategies Can Save Lives With Mitigation and Suppression of SARS-CoV-2 Infection: An Evidence Review

Methodical Approach to Inactivate Any Microbial Element like SARS-CoV2

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