Carbon dots as a fluorescent probe for label-free detection of physiological potassium level in human serum and red blood cells

Zhang, Lingyang; Chen, Shenna; Zhao, Qian; Huang, Haowen

doi:10.1016/j.aca.2015.04.057

Cited by 47 publications

(19 citation statements)

References 46 publications

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“…This is possible because our carbon dots contained aromatic units and carbonyl groups as proved by the FT‐IR, XPS, and UV‐vis results. Furthermore, Mg 2+ has a suitable size that possibly fits the cavity between functional groups in carbon dots as the size‐controlled ion detection of the carbon dots has been observed in previous studies [49–50] …”

Section: Resultsmentioning

confidence: 87%

High‐performance Mg²⁺ Sensors Based on Natural Rubber‐derived, Label‐free Carbon Dots

et al. 2022

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Detection of trace magnesium ion (Mg 2 + ) is important in environmental and health monitoring. In this work, highperformance Mg 2 + sensor was developed from label-free carbon dots. The novel carbon dots were prepared for the first time from natural rubber through the two-step pyrolysis and hydrothermal method. They showed selectivity towards Mg 2 + against a range of metal ions in solution and yielded a detection limit of 4.3 μM. The Mg 2 + detection in real water samples showed an excellent recovery of 97.21 to 99.21 %. A paper-based sensor was also fabricated as a portable device, showing a detection limit of 8.0 μM. UV-vis and X-ray absorption studies provided some evidences of the unique dynamic interactions between carbon dots and Mg 2 + ions. In summary, the novelty of this work lies upon (i) developing a methodology of converting abundant, low-cost natural rubber into carbon dots and (ii) fabricating sensitive and selective sensors from the label-free carbon dots for the detection of Mg 2 + both in solution and as paper-based devices. The findings in this work will therefore have potential for environmental and health monitoring applications.

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Section: Resultsmentioning

confidence: 87%

High‐performance Mg²⁺ Sensors Based on Natural Rubber‐derived, Label‐free Carbon Dots

et al. 2022

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“…< Fig. 29 is here > Potassium (K + ), calcium (Ca 2+ ), and magnesium (Mg 2+ ) are essential elements of the human body that play important roles in many physiological events, such as hyperpolarization in signal transduction of neurons, regulating cell osmotic pressure, apoptosis, muscle contraction, exocytosis, and humoral secretion [172][173][174][175][176]. For the detection of these metal ions, a number of bioanalytical methods, particular the responsive fluorescence probes have been developed recently [177][178][179][180][181][182][183], and some of them are capable of detecting and visualizing these metal ions in cell plasma membrane.…”

Section: Membrane-targeting Responsive Fluorescence Probes For Metal ...mentioning

confidence: 99%

Advances in the development of fluorescence probes for cell plasma membrane imaging

Liu

Gao

Yuan

et al. 2020

TrAC Trends in Analytical Chemistry

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“…Potassium ion (K + ) is the most abundant cellular metal cation and, thereby, plays essential roles in cardiac and neuronal excitability and cellular ionic homeostasis. Photoluminescent Carbon dots have been used as a fluorescent probe for the label-free detection of the potassium level in serum and red blood cells [47]. This fluorescent probe was reported to have an outstanding selectivity for K + /Na + and to be a suitable fluorescent tool to measure the physiological level of K + levels in the range of 10-80 mmol/L in vitro [48].…”

Section: Existing Probes For Detecting Molecular Events In Pathology mentioning

confidence: 99%

State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research

et al. 2018

Acta Pharmacol Sin

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Cardiovascular diseases, neuropsychiatric disorders, and cancers seriously endanger human health. Mechanistic and pharmacological mechanisms of candidate drugs are central to the translational paradigm. Since many signal transduction and molecular events are implicated in these diseases, a novel method to interrogate the key pharmacological mechanisms is required to accelerate innovative drug discovery. Much attention now focuses on the real-time visualization of molecular disease events to yield new insights to the pathogenesis of the diseases. This review focuses on recent advances in the development of chemical probes for imaging pathological events to facilitate the study of the underlying pharmacodynamics and toxicity involved. As reviewed here, optical imaging is now frequently viewed as an indispensable technique in the field of biological research. Promoting interdisciplinary collaboration among chemistry, biology and medicine, is necessary to further refine functional fluorescent probes for diagnostic and therapeutic applications.

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Carbon dots as a fluorescent probe for label-free detection of physiological potassium level in human serum and red blood cells

Cited by 47 publications

References 46 publications

High‐performance Mg²⁺ Sensors Based on Natural Rubber‐derived, Label‐free Carbon Dots

High‐performance Mg²⁺ Sensors Based on Natural Rubber‐derived, Label‐free Carbon Dots

Advances in the development of fluorescence probes for cell plasma membrane imaging

State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research

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Carbon dots as a fluorescent probe for label-free detection of physiological potassium level in human serum and red blood cells

Cited by 47 publications

References 46 publications

High‐performance Mg2+ Sensors Based on Natural Rubber‐derived, Label‐free Carbon Dots

High‐performance Mg2+ Sensors Based on Natural Rubber‐derived, Label‐free Carbon Dots

Advances in the development of fluorescence probes for cell plasma membrane imaging

State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research

Contact Info

Product

Resources

About

High‐performance Mg²⁺ Sensors Based on Natural Rubber‐derived, Label‐free Carbon Dots

High‐performance Mg²⁺ Sensors Based on Natural Rubber‐derived, Label‐free Carbon Dots