Carbon dots (CDs): basics, recent potential biomedical applications, challenges, and future perspectives

Hui, Shalmali

doi:10.1007/s11051-023-05701-w

Cited by 20 publications

(3 citation statements)

References 272 publications

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“…UV-Vis absorption spectroscopy revealed the π-π* electronic transitions of C=C bonds in the CD-L and CD-oPD graphitic nucleus, with bands centered at 225, 210 and 230 nm, respectively (Figure 2B) (Tadesse et al, 2018;Hui, 2023). In contrast, the n-π* transitions from C=O and C-N bonds can be observed in 278 e 320 nm for CD-L, and 290 e 430 nm for CD-oPD, respectively (Lu et al, 2021;Gedda et al, 2023).…”

Section: Resultsmentioning

confidence: 98%

Carbon dots-based fluorescent films to act as a potential antioxidant agent and pH ratiometric sensor for skin applications

Da Silva,

Araujo,

Almeida

et al. 2023

Front. Carbon

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The wound healing process is accompanied by changes in pH values. Monitoring this physicochemical parameter can indicate the effectiveness of the applied treatment and act as early identification of wound infection. This study focuses on the development of a fluorescent film-based polyvinyl alcohol (PVA) and carbon dots (CDs) derived from lemon bagasse (CD-L) and ortho-phenylenediamine (CD-oPD) named to act as antioxidants and potential ratiometric fluorescent pH sensors, in wound applications. The I460/I550 intensity ratio, as a function of pH value for the dual-system CDs prepared from the mixture of CD-L and CD-oPD, named CD-L/oPD, was investigated. The fit corresponded to a sigmoidal function in the pH range of 5–10, with a relationship having a r2 = 0.992. The variation in the values of the I460/I550 ratio allows for the visualization of the color change from yellowish-green to green with increasing pH. Through a simulated ex vivo pig skin model, it was possible to note that the films prepared from mixed of the CD-L and CD-oPD carbon dots incorporated in a matrix PVA named CD-L/oPD-F was more efficient at visually discriminating color in relation to changes in pH than the films prepared from both individual CD-L (CD-L-F) and CD-oPD (CD-oPD-F) carbon dots. CD-L and CD-oPD demonstrated antioxidant capacity against reactive oxygen species (ROS). The IC50 values for CD-L and CD-oPD were 56.7 and 39.5 μg mL−1 in the DPPH● inhibition assay, and 25.1 and 63.4 μg mL−1 in the HOCl scavenging one, respectively. MTT viability assays using human non-tumoral skin fibroblast (HFF-1) cell showed a cell survival rate of over 80% for both CDs up to a concentration of 1,000 μg mL−1. Finally, the developed films can act in a bifunctional way, by monitoring healing through pH changes and by acting as an antioxidant agent in the treatment of wounds.

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Section: Resultsmentioning

confidence: 98%

Carbon dots-based fluorescent films to act as a potential antioxidant agent and pH ratiometric sensor for skin applications

Da Silva,

Araujo,

Almeida

et al. 2023

Front. Carbon

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“…CNPs have been extensively explored for biomedical applications like photodynamic, photothermal and gene therapy, drug delivery, sensing and imaging. [1][2][3] The reports on biomedical applications of CNPs are mostly derived from in vitro studies and do not match the biological complexity experienced by nanoparticles in vivo. Nanoparticles, when administered in a physiological environment, interact with biomolecules like proteins and DNA.…”

Section: Introductionmentioning

confidence: 99%

Lysozyme adsorption on carbonaceous nanoparticles probed by second harmonic light scattering

Saikia,

Dutta,

Mishra

et al. 2023

Phys. Chem. Chem. Phys.

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“…CDs are characterized by a high fluorescence emission [ 3 ] due to their quantum confinement [ 4 ], water solubility [ 5 ] and high biocompatibility [ 6 ]. Their chemical features have spread their use across several fields with remarkable achievements as fluorescent probes in analytical procedures [ 7 , 8 , 9 ] and biomedical treatments [ 10 , 11 ] as active materials for both photocatalysis [ 12 , 13 ] and electrocatalysis [ 14 , 15 ]. The application of CDs has raised several issues related to what is and what is not a carbon dot together with serious concern about the development of a rational classification methodology [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Computational Investigation of Interactions between Carbon Nitride Dots and Doxorubicin

2023

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The study of carbon dots is one of the frontiers of materials science due to their great structural and chemical complexity. These issues have slowed down the production of solid models that are able to describe the chemical and physical features of carbon dots. Recently, several studies have started to resolve this challenge by producing the first structural-based interpretation of several kinds of carbon dots, such as graphene and polymeric ones. Furthermore, carbon nitride dot models established their structures as being formed by heptazine and oxidized graphene layers. These advancements allowed us to study their interaction with key bioactive molecules, producing the first computational studies on this matter. In this work, we modelled the structures of carbon nitride dots and their interaction with an anticancer molecule (Doxorubicin) using semi-empirical methods, evaluating both geometrical and energetic parameters.

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Carbon dots (CDs): basics, recent potential biomedical applications, challenges, and future perspectives

Cited by 20 publications

References 272 publications

Carbon dots-based fluorescent films to act as a potential antioxidant agent and pH ratiometric sensor for skin applications

Carbon dots-based fluorescent films to act as a potential antioxidant agent and pH ratiometric sensor for skin applications

Lysozyme adsorption on carbonaceous nanoparticles probed by second harmonic light scattering

Computational Investigation of Interactions between Carbon Nitride Dots and Doxorubicin

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