Carbon dots with tissue engineering and regenerative medicine applications

Farshidfar, Nima; Fooladi, Saba; Nematollahi, Mohammad Hadi; Iravani, Siavash

doi:10.1039/d3ra02336b

Cited by 21 publications

(6 citation statements)

References 106 publications

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“…The advantages of these sensors, combined with the unique properties of CDs, allow the development of new platforms for in situ pH detection in biological systems with high efficiency. In this regard, the obtained results are highly promising for early diagnosis, and treatment's monitoring of diseases, such as chronic wounds (Yang et al, 2019;Farshidfar et al, 2023;Sharma et al, 2023).…”

Section: Graphical Abstract 1 Introductionmentioning

confidence: 94%

“…pH-responsive property has positioned them as valuable tools for pH-sensing applications in various systems (Wang et al, 2020;Cui et al, 2021). Although studies on the treatment of wounds using CDs are in progress, the use of these nanoparticles in the detection of pH in wounds is rare (Omidi et al, 2017;Kasouni et al, 2021;Wu et al, 2022;Farshidfar et al, 2023). Omidi et al (2017) synthesized single-channel CDs with blue emission derived from ammonium citrate to fabricate CD/chitosan nanocomposite films for application in wound healing.…”

Section: Graphical Abstract 1 Introductionmentioning

confidence: 99%

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Carbon dots-based fluorescent films to act as a potential antioxidant agent and pH ratiometric sensor for skin applications

Da Silva,

Araujo,

Almeida

et al. 2023

Front. Carbon

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The wound healing process is accompanied by changes in pH values. Monitoring this physicochemical parameter can indicate the effectiveness of the applied treatment and act as early identification of wound infection. This study focuses on the development of a fluorescent film-based polyvinyl alcohol (PVA) and carbon dots (CDs) derived from lemon bagasse (CD-L) and ortho-phenylenediamine (CD-oPD) named to act as antioxidants and potential ratiometric fluorescent pH sensors, in wound applications. The I460/I550 intensity ratio, as a function of pH value for the dual-system CDs prepared from the mixture of CD-L and CD-oPD, named CD-L/oPD, was investigated. The fit corresponded to a sigmoidal function in the pH range of 5–10, with a relationship having a r2 = 0.992. The variation in the values of the I460/I550 ratio allows for the visualization of the color change from yellowish-green to green with increasing pH. Through a simulated ex vivo pig skin model, it was possible to note that the films prepared from mixed of the CD-L and CD-oPD carbon dots incorporated in a matrix PVA named CD-L/oPD-F was more efficient at visually discriminating color in relation to changes in pH than the films prepared from both individual CD-L (CD-L-F) and CD-oPD (CD-oPD-F) carbon dots. CD-L and CD-oPD demonstrated antioxidant capacity against reactive oxygen species (ROS). The IC50 values for CD-L and CD-oPD were 56.7 and 39.5 μg mL−1 in the DPPH● inhibition assay, and 25.1 and 63.4 μg mL−1 in the HOCl scavenging one, respectively. MTT viability assays using human non-tumoral skin fibroblast (HFF-1) cell showed a cell survival rate of over 80% for both CDs up to a concentration of 1,000 μg mL−1. Finally, the developed films can act in a bifunctional way, by monitoring healing through pH changes and by acting as an antioxidant agent in the treatment of wounds.

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Section: Graphical Abstract 1 Introductionmentioning

confidence: 94%

Section: Graphical Abstract 1 Introductionmentioning

confidence: 99%

Carbon dots-based fluorescent films to act as a potential antioxidant agent and pH ratiometric sensor for skin applications

Da Silva,

Araujo,

Almeida

et al. 2023

Front. Carbon

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“…132 Further details on the applications of CQDs, especially pertaining to their role in tissue engineering and regenerative medicine, can be found in two recently published reviews. 133,134 Carbon Nanotubes (CNTs)…”

Section: Dovepressmentioning

confidence: 99%

Carbon Nanomaterial-Based Hydrogels as Scaffolds in Tissue Engineering: A Comprehensive Review

Stocco,

Zhang,

Dimitrov

et al. 2023

IJN

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Carbon-based nanomaterials (CBNs) are a category of nanomaterials with various systems based on combinations of sp2 and sp3 hybridized carbon bonds, morphologies, and functional groups. CBNs can exhibit distinguished properties such as high mechanical strength, chemical stability, high electrical conductivity, and biocompatibility. These desirable physicochemical properties have triggered their uses in many fields, including biomedical applications. In this review, we specifically focus on applying CBNs as scaffolds in tissue engineering, a therapeutic approach whereby CBNs can act for the regeneration or replacement of damaged tissue. Here, an overview of the structures and properties of different CBNs will first be provided. We will then discuss state-of-the-art advancements of CBNs and hydrogels as scaffolds for regenerating various types of human tissues. Finally, a perspective of future potentials and challenges in this field will be presented. Since this is a very rapidly growing field, we expect that this review will promote interdisciplinary efforts in developing effective tissue regeneration scaffolds for clinical applications.

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“…20 Meanwhile, the bioavailability and targeting effectiveness of drugs will be significantly enhanced. 21,22 As a result, CQDs have emerged as excellent candidates for tumor therapy.…”

Section: Introductionmentioning

confidence: 99%

Novel Carbon Quantum Dots Precisely Trigger Ferroptosis in Cancer Cells through Antioxidant Inhibition Synergistic Nanocatalytic Activity

Jin,

Wang,

Yin

et al. 2024

ACS Appl. Mater. Interfaces

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High levels of glutathione (GSH) are an important characteristic of malignant tumors and a significant cause of ineffective treatment and multidrug resistance. Although reactive oxygen species (ROS) therapy has been shown to induce tumor cell death, the strong clearance effect of GSH on ROS significantly reduces its therapeutic efficacy. Therefore, there is a need to develop new strategies for targeting GSH. In this study, novel carbon quantum dots derived from gentamycin (GM-CQDs) were designed and synthesized. On the basis of the results obtained, GM-CQDs contain sp 2 and sp 3 carbon atoms as well as nitrogen oxygen groups, which decrease the intracellular levels of GSH by downregulating SLC7A11, thereby disrupting redox balance, mediating lipid peroxidation, and inducing ferroptosis. Transcriptome analysis demonstrated that GM-CQDs downregulated the expression of molecules related to GSH metabolism while significantly increasing the expression of molecules related to ferroptosis. The in vivo results showed that the GM-CQDs exhibited excellent antitumor activity and immune activation ability. Furthermore, because of their ideal biological safety, GM-CQDs are highly promising for application as drugs targeting GSH in the treatment of malignant tumors.

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Carbon dots with tissue engineering and regenerative medicine applications

Abstract: Recent advancements and new discoveries of CDs in TE-RM are deliberated, focusing on challenges and future perspectives.

Cited by 21 publications

References 106 publications

Carbon dots-based fluorescent films to act as a potential antioxidant agent and pH ratiometric sensor for skin applications

Carbon dots-based fluorescent films to act as a potential antioxidant agent and pH ratiometric sensor for skin applications

Carbon Nanomaterial-Based Hydrogels as Scaffolds in Tissue Engineering: A Comprehensive Review

Novel Carbon Quantum Dots Precisely Trigger Ferroptosis in Cancer Cells through Antioxidant Inhibition Synergistic Nanocatalytic Activity

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