Carbon nanodots featuring efficient FRET for two-photon photodynamic cancer therapy with a low fs laser power density

Wang, Jing; Zhang, Zehui; Zha, Shuai; Zhu, Yinyan; Wu, Peiyi; Ehrenberg, Benjamin; Chen, Jiyao

doi:10.1016/j.biomaterials.2014.07.063

Cited by 139 publications

(100 citation statements)

References 43 publications

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“…Yang et al succeeded in using C-dots for the in vivo studies of optical imaging with mice for animal test. Followed by these, as a result of extensive and multidisciplinary efforts, C-dots have found their place in a wide range of applications in nanoprobes [56][57][58][59][60][61][62][63][64][65][66], drug delivery [67][68][69][70][71], therapy [72][73][74][75][76], and optoelectronic devices [77][78][79][80][81][82].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Analytical Separation of Fluorescent Carbon Nanodots

Gong

Liu

et al. 2017

Journal of Nanomaterials

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Carbon nanodots (C-dots) are recently discovered fluorescent carbon nanoparticles with typical sizes of <10 nm. The C-dots have been reported to have excellent photophysical and chemical characteristics. In recent years, the advances in the development and improvement in C-dots synthesis, characterization, and applications are burgeoning. In this review, we introduce the most commonly used techniques for the characterization of C-dots. The characterization techniques for C-dots are briefly classified, described, and illustrated with applied examples. In addition, the analytical separation methods for C-dots (including electrophoresis, chromatography, density gradient centrifugation, differential centrifugation, solvent extraction, and dialysis) are included and discussed according to their analytical characteristics. The review concludes with an outlook towards the future developments in the characterization and the analytical separation of C-dots. The comprehensive overview of the characterization and the analytical separation techniques will safeguard people to use each technique more wisely.

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Section: Introductionmentioning

confidence: 99%

Characterization and Analytical Separation of Fluorescent Carbon Nanodots

Gong

Liu

et al. 2017

Journal of Nanomaterials

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“…Intriguingly, Chen and co-workers employed a two-photon excitation FRET strategy to excite a 5,10,15,20-tetrakis(1-methyl 4-pyridinio) porphyrin PS, which caused HeLa cell death through PDT. 213 Regarding CNTs, the two-photon excitation spectra of SWNTs were first reported by Dukovic and co-workers. 219 The excitation binding energies of CNTs from two-photon PL were subsequently investigated by the same groups 220 and Maultzsch et al 221 However, for nonlinear optical bioimaging, the aggregation and poor solubility of CNTs in aqueous-based environments should be avoided.…”

Section: Nir-absorbing Organic Materials: Dyes and Polymersmentioning

confidence: 99%

“…212 According to the experimental results and theoretical simulations, they found that graphitic-C 3 N 4 QDs emit strong blue fluorescence at 400 nm and green emission under one-photon UV excitation and two-photon excitation at 780 nm. In addition to these successful syntheses of carbon-based QDs, the conduction of TPF microscopy made water-dispersed and biocompatible carbon QDs, which might offer new advantages in biosensing, drug delivery, two-photon photodynamic cancer therapy, 213 cellular tracking 212,214,215 and deep-tissue imaging. 209 Ray et al also reported that graphene oxide featured an extremely high 46 890 GM of TPA for selective two-photon imaging of SK-BR-3 breast tumor cells.…”

Section: Nir-absorbing Organic Materials: Dyes and Polymersmentioning

confidence: 99%

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

et al. 2016

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With the development of nonlinear optics and new imaging methods, near-infrared (NIR) light can excite contrast agents to probe biological specimens both functionally and structurally with a deeper imaging depth and a higher spatial resolution than linear optical approaches. There is considerable and growing interest in how biological specimens respond to NIR light. Moreover, the visible absorption band of most functional nanomaterials becomes NIR-excitable through multiphoton processes, thus allowing multifunctional imaging and combined therapy with noble metal and magnetic nanoparticles both in vitro and in vivo. A groundbreaking example is the use of different laser techniques to excite single-type NIR-absorbing/emitting nanomaterials to produce multiphoton emission by femtosecond lasers using either a remote control system for photodynamic therapy or photo-induced chemical bond dissociation. These techniques provided superior anatomical resolution and detection sensitivity for in vivo tumor-targeted imaging than those offered by conventional methods. Here we summarize the most recent progress in the development of smart NIR-absorbing/emitting nanomaterials for in vivo bioapplications.

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“…CDs have been extensively used in various fields, including diagnosis, drug delivery and gene delivery, showing excellent properties [10,28,29] . However, toxicity concerns should be addressed before employing nanomaterials in humans.…”

Section: Discussionmentioning

confidence: 99%

Polyethylene glycol modification decreases the cardiac toxicity of carbonaceous dots in mouse and zebrafish models

et al. 2015

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Aim: Carbonaceous dots (CDs), which have been used for diagnosis, drug delivery and gene delivery, are accumulated in heart at high concentrations. To improve their biocompatibility, polyethylene glycol-modified CDs (PEG-CDs) were prepared. In this study we compared the cardiac toxicity of CDs and PEG-CDs in mouse and zebrafish models. Methods: Mice were intravenously treated with CDs (size: 4.9 nm, 5 mg·kg -1 ·d -1 ) or PEG-CDs (size: 8.3 nm, 5 mg·kg -1 ·d -1 ) for 21 d. Their blood biochemistry indices, ECG, and histological examination were examined for evaluation of cardiac toxicity. CDs or PEG-CDs was added in incubator of cmlc2 transgenic Zebrafish embryos at 6 hpf, and the shape and size of embryos' hearts were observed at 48 hpf using a fluorescent microscope. Furthermore, whole-mount in situ hybridization was used to examine the expression of early cardiac marker gene (clml2) at 48 hpf. Results: Administration of CDs or PEG-CDs in mice caused mild, but statistically insignificant reduction in serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels detected at 7 d, which were returned to the respective control levels at 21 d. Neither CDs nor PEG-CDs caused significant changes in the morphology of heart cells. Administration of CDs, but not PEG-CDs, in mice caused marked increase of heart rate. Both CDs and PEG-CDs did not affect other ECG parameters. In the zebrafish embryos, addition of CDs (20 μg/mL) caused heart development delay, whereas addition of CDs (80 μg/mL) led to heart malformation. In contrast, PEG-CDs caused considerably small changes in heart development, which was consistent with the results from the in situ hybridization experiments. Conclusion: CDs causes greater cardiac toxicity, especially regarding heart development. Polyethylene glycol modification can attenuate the cardiac toxicity of CDs.

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Carbon nanodots featuring efficient FRET for two-photon photodynamic cancer therapy with a low fs laser power density

Cited by 139 publications

References 43 publications

Characterization and Analytical Separation of Fluorescent Carbon Nanodots

Characterization and Analytical Separation of Fluorescent Carbon Nanodots

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

Polyethylene glycol modification decreases the cardiac toxicity of carbonaceous dots in mouse and zebrafish models

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