Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis

Wierzbicki, Mateusz; Sawosz, Ewa; Grodzik, Marta; Hotowy, Anna; Prasek, Marta; Jaworski, Sławomir; Sawosz, Filip; Chwalibog, A.

doi:10.2147/ijn.s49745

Cited by 24 publications

(21 citation statements)

References 48 publications

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“…In contrast, the biological activity of graphite NPs (nanographite, NG) is poorly understood. There are only a few published reports on this subject, suggesting that NG is capable of inducing apoptosis and cell death or inflammatory responses in rats [ 4 ], or could inhibit angiogenesis [ 5 ]. Despite the similarity, in terms of having a crystalline form and nanoscale size, ND and NG have different C-atoms hybridization (sp 3 and sp 2 , respectively) and, thus, exhibit distinct physical and electrochemical properties.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Cytotoxicity of Carbon-Based Nanoparticles, Diamond and Graphite, in Human Glioblastoma and Hepatoma Cell Lines

et al. 2015

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Nanoparticles have attracted a great deal of attention as carriers for drug delivery to cancer cells. However, reports on their potential cytotoxicity raise questions of their safety and this matter needs attentive consideration. In this paper, for the first time, the cytotoxic effects of two carbon based nanoparticles, diamond and graphite, on glioblastoma and hepatoma cells were compared. First, we confirmed previous results that diamond nanoparticles are practically nontoxic. Second, graphite nanoparticles exhibited a negative impact on glioblastoma, but not on hepatoma cells. The studied carbon nanoparticles could be a potentially useful tool for therapeutics delivery to the brain tissue with minimal side effects on the hepatocytes. Furthermore, we showed the influence of the nanoparticles on the stable, fluorescently labeled tumor cell lines and concluded that the labeled cells are suitable for drug cytotoxicity tests.

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Section: Introductionmentioning

confidence: 99%

Analysis of the Cytotoxicity of Carbon-Based Nanoparticles, Diamond and Graphite, in Human Glioblastoma and Hepatoma Cell Lines

et al. 2015

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“…In previous in vivo and in vitro studies, carbon-based nanosized allotropes (mostly single-walled carbon nanotubes, multi-walled carbon nanotubes and CB, diamond and graphite NPs, C 60 ) have been widely described to cause the inhibition of angiogenesis and vasorelaxation, enhance monocyte adhesion even atherosclerosis and other adverse effects on the cardiovascular system (Cao, Jacobsen, et al, 2014;Cao, Roursgaard, Danielsen, Moller, & Loft, 2014;Gutierrez-Hernandez et al, 2015;Thompson et al, 2014;Wierzbicki et al, 2013). Lately, there was mounting epidemiological evidence of a link between long-term BC exposure and human cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Prolonged exposure to carbon nanoparticles induced methylome remodeling and gene expression in zebrafish heart

Zhou

Tian²,

et al. 2018

J of Applied Toxicology

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Growing black carbon (BC) emission has become one of the major urgent environmental issues facing human beings. Usually, BC or BC‐containing carbon nanoparticles (CNPs) were recognized as non‐directly toxic components of atmospheric particulate matter. However, epidemiology studies have provided much evidence of the associations of exposure of particulate‐containing carbon particles with cardiovascular diseases. There are still no related studies to support the epidemiological conclusions. Hence, in this article we exposed adult zebrafish to CNPs for 60 days, and then explored the heart location and potential adverse effects on cardiac tissues of these nanosized carbon particles. Our results first showed direct visualization of cardiac endothelial uptake and heart deposition of CNPs in zebrafish. In addition, CNPs caused significant ultrastructural alterations in myocardial tissue and induced the expression of inflammatory cytokines in a dose‐dependent manner, resulting in sub‐endocardial inflammation and cell apoptosis. Moreover, our data demonstrated the perturbations caused by CNPs on DNA methylation, suggesting that DNA methylome remodeling might play a critical role in CNP‐induced cardiotoxicity in zebrafish heart. Therefore, this study not only proved a laboratory link between CNP exposure and cardiotoxicity in vivo, but also indicated a possible toxicity mechanism involved.

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“…Upon incubation of DNDs with chicken embryos, ND exposure caused a downregulation of bFGF expression, which led to a decrease in the angiogenic activity. Histological analysis determined that DNDs exposure resulted in a decline in both the density and length of vessels in the embryos, though no other cytotoxic or detrimental effects were observed [74]. Similarly, in a comparative study of different carbon-based nanomaterial DNDs produced the highest antiangiogenic effect in ovo chicken embryo chorioallantoic membranes (CAM) and this effect was explained by the reduction induced by DNDs on the levels of pro-angiogenic growth factor receptors [75].…”

Section: Synthesis and Functionalization Of Ndsmentioning

confidence: 99%

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Whitlow

Pacelli

Paul

2017

Journal of Controlled Release

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With recent advances in the field of nanomedicine, many new strategies have emerged for diagnosing and treating diseases. At the forefront of this multidisciplinary research, carbon nanomaterials have demonstrated unprecedented potential for a variety of regenerative medicine applications including novel drug delivery platforms that facilitate the localized and sustained release of therapeutics. Nanodiamonds (NDs) are a unique class of carbon nanoparticles that are gaining increasing attention for their biocompatibility, highly functional surfaces, optical properties, and robust physical properties. Their remarkable properties have established NDs as an invaluable regenerative medicine platform, with a broad range of clinically relevant applications ranging from targeted delivery systems for insoluble drugs, bioactive substrates for stem cells, and fluorescent probes for long-term tracking of cells and biomolecules in vitro and in vivo. This review introduces the synthesis techniques and the various routes of surface functionalization that allow for precise control over the properties of NDs. It also provides an in-depth overview of the current progress made towards the use of NDs in the fields of drug delivery, tissue engineering, and bioimaging. Their future outlook in regenerative medicine including the current clinical significance of NDs, as well as the challenges that must be overcome to successfully translate the reviewed technologies from research platforms to clinical therapies will also be discussed.

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Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis

Cited by 24 publications

References 48 publications

Analysis of the Cytotoxicity of Carbon-Based Nanoparticles, Diamond and Graphite, in Human Glioblastoma and Hepatoma Cell Lines

Analysis of the Cytotoxicity of Carbon-Based Nanoparticles, Diamond and Graphite, in Human Glioblastoma and Hepatoma Cell Lines

Prolonged exposure to carbon nanoparticles induced methylome remodeling and gene expression in zebrafish heart

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

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