The use of LEDs for plant lighting (phytolighting) provides a more energy- efficient alternative to traditional lighting methods. Combination of LEDs with different spectral composition and the possibility to change the composition of resulting radiation in a single lighting device allows one to improve the efficiency of phytolighting systems and optimize them for different conditions of plant growth and development. In this work, we have investigated quasi-monochromatic LEDs specialized for efficient phytolighting and efficient white LEDs with different CRI. Being based on the research, the most effective LEDs for building phytolighting systems have been identified, and their optimal ratio with red quasi-monochromatic LEDs for building phytolighting systems in rooms with a constant presence of people (greenhouses, winter gardens, etc) has been determined.