Carbon quantum dots derived from polysaccharides: Chemistry and potential applications

Emam, Hossam E.

doi:10.1016/j.carbpol.2023.121503

Cited by 27 publications

(1 citation statement)

References 114 publications

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“…Carbon dots (CDs) are a relatively new class of carbon-based materials with antimicrobial properties and low toxicity to mammalian cells [21][22][23][24][25][26]. These nanoparticles can be readily prepared from biological carbon sources with various functional groups on their surfaces using a simple process.…”

Section: Introductionmentioning

confidence: 99%

Modifying cellulose fibres with carbon dots: a promising approach for the development of antimicrobial fibres

Radha,

Makhlouf,

Diab

et al. 2024

R. Soc. Open Sci.

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This study focuses on the development of antimicrobial fibres for use in medical and healthcare textile industries. Carbon dots (CDs) were designed with boronic acid groups for the attachment to cellulose fibres found in cotton textiles and to enhance their attachment to glycogens on bacterial surfaces. Boronic acid-based and curcumin-based CDs were prepared and characterized using various techniques, showing a nanoscale size and zeta potential values. The CDs inhibited the growth of both Staphylococcus epidermidis and Escherichia coli bacteria, with UV-activated CDs demonstrating improved antibacterial activity. The antimicrobial activity of the CDs was then tested, revealing strong adherence to cellulose paper fibres with no CD diffusion and potent inhibition of bacterial growth. Cytotoxicity assays on human cell lines showed no toxicity towards cells at concentrations of up to 100 µg ml −1 but exhibited increased toxicity at concentrations exceeding 1000 µg ml −1 . However, CD-modified cellulose paper fibres showed no toxicity against human cell lines, highlighting the antimicrobial properties of the CD-modified cellulose fibres are safe for human use. These findings show promising potential for applications in both industrial and clinical settings.

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Section: Introductionmentioning

confidence: 99%

Modifying cellulose fibres with carbon dots: a promising approach for the development of antimicrobial fibres

Radha,

Makhlouf,

Diab

et al. 2024

R. Soc. Open Sci.

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Carbon Dots as Bioactive Antifungal Nanomaterials

Sturabotti,

Camilli,

Leonelli

et al. 2024

ChemMedChem

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Nowadays, the widespread diffusion of infections caused by opportunistic fungi represents a demanding threat for global health security. This phenomenon has also worsened by the emergence of contagious events in hospitalisation environments and by the fact that many fungi have developed harsh and serious resistance mechanisms to the traditional antimycotic drugs. Hence, the design of novel antifungal agents is a key factor to counteract mycotic infections and resistance. Within this context, nanomaterials are gaining increasing attention thanks to their biocidal character. Among these, carbon dots (CDs) represent a class of zero‐dimensional, photoluminescent and quasi‐spherical nanoparticles which, for their great and tuneable features, have found applications in catalysis, sensing and biomedicine. Nevertheless, only a few works define and recapitulate their antifungal properties. Therefore, we aim to give an overview about the recent advances in the synthesis of CDs active against infective fungi. We described the general features of CDs and fungal cells, by highlighting some of the most common antimycotic mechanisms. Then, we evaluated the effects of CDs, antimicrobial drugs‐loaded CDs and CDs‐incorporated packaging systems on different fungi and analysed the use of CDs as fluorescent nano‐trackers for bioimaging, showing, to all effects, their promising application as antifungal agents.

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Commercial Wheat and Oat Flour Derived Fluorescent Carbon Quantum Dots through Sustainable Hydrothermal Synthesis and Their Biological Activities

Kuppusamy,

Kim,

Park

et al. 2024

ChemistrySelect

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In this study, we utilized processed edible commercial wheat and oat flours to synthesize highly fluorescent carbon dots using green hydrothermal synthesis. The as‐synthesized carbon quantum dots (CQDs) were characterized using UV‐vis spectrophotometry, photoluminescence spectrophotometry, high‐resolution transmission electron microscopy, and Fourier transform infrared spectroscopy. The synthesized wheat‐CQDs (W‐CQDs) and oat‐CQDs (O‐CQDs) had monodispersed spherical shapes with average sizes of 3–8 and 5–10 nm, respectively, and exhibited strong fluorescence intensity and excitation‐dependent photoluminescence. The W‐CQDs and O‐CQDs were highly dispersed in aqueous solutions and exhibited bright green and blue fluorescence, respectively, under UV light (λex=380 and 370 nm). Both CQDs contained abundant functional groups, including amino, hydroxyl, and carboxyl groups, which may play a major role in biological applications. The W‐CQDs and O‐CQDs showed good free‐radical scavenging capacity in the 2,2‐diphenylpicrylhydrazyl (DPPH) and H2O2 assays. The anti‐inflammatory activities of W‐CQDs and O‐CQDs were more effective than that of the standard, with EC50 values of 1.8 and 1.3 mg/mL, respectively, in the protein denaturation assay. Additionally, the CQDs exhibited low cytotoxicity toward NIH3T3 fibroblast and human HeLa cervical cancer cells when treated with a 5‐mg/mL concentration. Therefore, green‐synthesized W‐CQDs and O‐CQDs are easily available, less cytotoxic, and applicable to therapeutic and cell nanocarrier purposes.

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Carbon quantum dots derived from polysaccharides: Chemistry and potential applications

Cited by 27 publications

References 114 publications

Modifying cellulose fibres with carbon dots: a promising approach for the development of antimicrobial fibres

Modifying cellulose fibres with carbon dots: a promising approach for the development of antimicrobial fibres

Carbon Dots as Bioactive Antifungal Nanomaterials

Commercial Wheat and Oat Flour Derived Fluorescent Carbon Quantum Dots through Sustainable Hydrothermal Synthesis and Their Biological Activities

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