Carbonic anhydrase activators. Part 14. Syntheses of mono and bis pyridinium salt derivatives of 2-amino-5-(2-aminoethyl)- and 2-amino-5-(3-aminopropyl)-1,3,4-thiadiazole and their interaction with isozyme II

Unsymmetrical Schiff Base Functionalized as Monobasic Tridentate Ligand on Complexation with Some Transition Metal Ions

“…A Pt wire is used as a working electrode and Ag/ AgCl as a reference electrode. Magnetic susceptibility measurements were carried out at room temperature in powder form on a vibrating sample magnetometer PAR 155 with 5000G-field strength, using Co[Hg(SCN) 4 ] as the calibrant(magnetic susceptibility ≈ 1.644 × 10 -5 cm 3 g -1 ). Rigaku model 8150 thermoanalyser was used for simultaneous recording of TG-DTA curves at a heating rate of 10 min -1 .…”

“…M. reveals square planar geometry around the metal ion [26]. Cobalt (II) complex shows absorption bands at 665 nm assigned to 4 A 2 → 4 T 1 (P) transitions. The existence of spin -orbit coupling also allows some quartet → doublet spin transition to occur.…”

“…Schiff base complexes are used as catalyst in some chemical processes, as biological models for understanding the structures of bio-molecules and to emulate the activity of proteins 1 . Several azomethines were reported to possess remarkable antimicrobial 2 , anticancer 3 and diuretic activities 4 . Schiff bases and their complexes were recently found to have significant antitumor and biological activity 5 .…”

Design, synthesis and evaluation of18F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging

“…The inhibition constant (K i ) was obtained by considering the classical Michaelis-Menten equation, which has been fitted by non-linear least squares by using PRISM 3. All CA isozymes used in the experiments were purified human recombinant proteins obtained as reported earlier by our group [35][36][37][38][39][40][41][42][43][44][45] .…”

4-phenyldiazenyl 2-(phenylimino methyl) phenols; synthesis and in-vitro biological evaluation as potential antibacterial agents

“…These compounds are readily hydrolyzed under acidic conditions leading to active aldehydes which can act as alkylating agents [2]. Besides, several azomethines have been reported to possess remarkable antibacterial [3 -9], antifungal [10 -14], anticancer [15][16][17][18][19], antioxidant [20], antimycobacterial [21], antitumor [22 -24], antiviral [25], antiHIV [26 -28] herbicidal [29] and diuretic activities [30]. The azomethine derivatives and their complexes derived from o-formylphenoxyacetic acid with aminothiazoles, a number of aminobenzene derivatives, and some heterocyclic & aliphatic amines have revealed biological significance such as antimetabolites of pyridoxal phosphate [31], bacteriostatic activity [32] and chorismate synthase inhibition [33].…”