2020
DOI: 10.1111/ipd.12717
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Carbonic anhydrase VI activity in saliva and biofilm can predict early childhood caries: A preliminary study

Abstract: Aim This study aimed to investigate whether carbonic anhydrase VI activity (CA VIACT), pH, and buffering capacity (BC) in saliva and biofilm could predict the number of lesion occurrence and early childhood caries (ECC). Design A cross‐sectional study was performed in a sample of 44 children aged 4 to 5 years who were examined regarding their caries status (dmfs + active white spot lesions–WSL) and allocated into two groups: ECC and caries‐free (CF). Saliva and biofilm were collected to determine pH, BC, and C… Show more

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Cited by 9 publications
(28 citation statements)
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“…Recognizing the role of CA VI in the bicarbonate pH-buffering system behavior 9 11 , we investigated the catalytic activity of CA VI under the experimental conditions tested in this study. Regarding the main effect of the disease, consistent with previous studies 12 , 14 , 17 , caries-active subjects had a higher CA VI activity when compared with caries-free subjects. Moreover, the nuances of buffering capacity according to healthy and diseased status imply that protein function is profoundly affected by ECC.…”
Section: Discussionsupporting
confidence: 90%
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“…Recognizing the role of CA VI in the bicarbonate pH-buffering system behavior 9 11 , we investigated the catalytic activity of CA VI under the experimental conditions tested in this study. Regarding the main effect of the disease, consistent with previous studies 12 , 14 , 17 , caries-active subjects had a higher CA VI activity when compared with caries-free subjects. Moreover, the nuances of buffering capacity according to healthy and diseased status imply that protein function is profoundly affected by ECC.…”
Section: Discussionsupporting
confidence: 90%
“…A blinded researcher (nutritionist) analyzed this dietary information and, with the help of software, assessed the amount of fermentable carbohydrates ingested by each child. The amount of sugar ingested per day (grams/day) and the relative percentage of sugar amount concerning all macronutrients from the diet were estimated by the average consumption in grams in the three days of the dairy filling 14 .…”
Section: Methodsmentioning
confidence: 99%
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“…A mean CA VI concentration is significantly lower in the active caries group than in the caries-free group [ 89 ]. When the activity of CA VI is measured in the caries group, it is increased, but there is no increased ability of CA VI to buffer and buffering capacity of saliva is lower in the caries group [ 91 ]. Moreover, the ability of CA VI to buffer is more related to its concentration than its activity, but elevated CA VI concentrations in saliva do not necessarily indicate that the enzyme is active [ 92 ].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the buffering capacity of saliva is closely related to the activity of carbonic anhydrase VI (CA VI) isoenzyme, which accelerates the removal of acid (H + ) from the local environment, increasing the buffering capacity of saliva, 12 and enabling acid neutralization in the biofilm structure 13 . Studies on isoenzyme attest its relevance to the prevalence and susceptibility to dental caries 4,14,15 …”
Section: Introductionmentioning
confidence: 99%