Carbosilane Dendrimers

Roovers, Jacques; Ding, Jianfu

doi:10.1007/978-1-4020-8174-3_3

Cited by 8 publications

(4 citation statements)

References 186 publications

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“…the Si-C-C bond angle (109.5 ) [Zhou and Roovers (1993); Roovers and Ding (2009)]. Figure 1(C) illustrates the molecular details of the carbosilane dendritic core and the coupling of linear polybutadiene chains to form the star [Gauthier and Munam (2010)].…”

Section: Depletion Gels From Soft Colloidal Glassesmentioning

confidence: 99%

Depletion gels from dense soft colloids: Rheology and thermoreversible melting

Truzzolillo¹,

Vlassopoulos²,

Munam³

et al. 2014

Journal of Rheology

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SynopsisUpon addition of small nonadsorbing linear polymers, colloidal glasses composed of large hard spheres melt and eventually revitrify into the so-called attractive glass regime. We show that, when replacing the hard spheres by star polymers representing model soft particles, a reentrant gel is formed. This is the result of compression and depletion of the stars due to the action of the osmotic pressure from the linear homopolymers. The viscoelastic properties of the soft dense gel were studied with emphasis on the shear-induced yielding process, which involved localized breaking of elements with a size of the order of the correlation length. Based on these results, a phenomenological attempt was made at describing the universal rheological features of colloid/nonadsorbing polymer mixtures of varying softness. The star gel was found to undergo thermoreversible melting, despite the fact that conventional hard-sphere depletion gels are invariant to heating. This phenomenon is attributed to the hybrid internal microstructure of the stars, akin to a dry-to-wet brush transition, and is characterized by slow kinetics, on the time scale of the osmotic gel formation process. These results may be useful in finding generic features in colloidal gelation, as well as in the molecular design of new soft composite materials. V C 2014 The Society of Rheology. [http://dx

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Section: Depletion Gels From Soft Colloidal Glassesmentioning

confidence: 99%

Depletion gels from dense soft colloids: Rheology and thermoreversible melting

Truzzolillo¹,

Vlassopoulos²,

Munam³

et al. 2014

Journal of Rheology

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“…Synthesis of fully developed CBS was performed in 1990s by three research groups, namely van der Made et al, Zhou et al, and Muzafarov et al62 This type of dendrimers can be distinguished by relatively easy synthesis, which is performed mainly by the divergent method, kinetic and thermodynamic stability resulting from the high energy of C–Si bond. Low polarity of this bond entails a hydrophobic character of the nanomolecule, which can be, however, abolished by modification of the surface with hydrophilic functional groups 63. The possibility of synthesis of water‐soluble CBS with various moieties at the termini renders them useful in medical applications.…”

Section: Carbosilane Dendrimersmentioning

confidence: 99%

Dendrimers—revolutionary drugs for infectious diseases

Łaźniewska

Miłowska

Gabryelak

2012

WIREs Nanomed Nanobiotechnol

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Over recent years innovative nanomolecules in a form of dendrimers have been gaining increasing interest. These compounds can be designed and modified in many ways giving a molecule which meets required expectations. For this reason dendrimers are the object of intensive studies in many fields of nanoscience including one of the most thriving—biomedicine. Numerous studies provide evidence that some dendrimers exhibit activities against many species/strains of viruses, bacteria, fungi, and prions. These types of dendritic nanostructures which are distinguished by antipathogenic properties and low cytotoxicity to eukaryotic cells may be potentially applied in medicine as novel drugs for various infectious diseases, especially those which are persistent, marked by high mortality rate, or untreatable. Dendrimers can exert their effect via different mechanisms of action, which are, in most cases, related to multivalency of the nanomolecule. The application of dendrimers is likely to be a breakthrough in prevention and treatment of infectious diseases which still beset humanity and may significantly improve the quality of people's life. WIREs Nanomed Nanobiotechnol 2012, 4:469–491. doi: 10.1002/wnan.1181 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

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“…Accordingly the effect of changing scriptl on, for example, rheological or calorimetric characteristics would be quite tangible. Moreover, to date, representative series of carbosilane dendrimers with well-known −(CH 2 ) 2 , and −(CH 2 ) 3 – − distances between the branch nodes have been synthesized and studied in detail, so they are ready-made objects for comparison.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Carbosilane Dendrimers with Variable Distance between Branching Nodes

2012

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Contents1. Experimental Data continuation 1-5 2. DLS Data 6 3. NMR 13 C of dendrimer G-2-(C 3 -Si-C 3 )-All-1, recorded on the Bruker DRX500.6-8 Experimental Data continuationG-1,5-C 3 -Si-C 3 -Cl-1. This was prepared from G-1-C 3 -Si-C 3 -All-2 (40.0 g, 0.037 mol), dimethylchlorosilane (68.13 g, 0.720 mol) and PC-072 (70 µl) according to the procedure similar to that described for G-1-C 3 -Si-C 3 -Cl-2. The yield of the target product was 98% (67.25 g).

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Carbosilane Dendrimers

Cited by 8 publications

References 186 publications

Depletion gels from dense soft colloids: Rheology and thermoreversible melting

Depletion gels from dense soft colloids: Rheology and thermoreversible melting

Dendrimers—revolutionary drugs for infectious diseases

Synthesis of Carbosilane Dendrimers with Variable Distance between Branching Nodes

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