Carboxylated Cellulose as a Soft Template Combined with PEDOT Derivatives in [BMIM]Cl: A Competent Biosensor for Detection of Guanine and Uric Acid in the Blood

Abstract

In this paper, carboxylated cellulose (CLC) dissolved in [BMIM]­Cl as a soft template combined with the functional group (−NH2, −SH)-grafted poly­(3,4-ethylene dioxythiophene) (PEDOT) derivatives was synthesized by an in situ polymerization method. Structural analysis revealed that CLC increased the degree of conjugation of the polymers in the composites and also led to the formation of the fibrous and sheet structure of the composite. The results of the electrochemical performance measurements revealed that the electrode modified by PEDOT-MeNH2/CLC and PEDOT-MeSH/CLC had detection limits (S/N = 3) of 0.38­(0.1–380 μM) and 0.042­(0.02–520 μM) for the detection of guanine (G), while for the detection of uric acid (UA), the corresponding detection limits (S/N = 3) were 0.255­(5–400 μM) and 0.085­(0.4–650 μM). The PEDOT-MeSH/CLC-based electrochemical sensor also possessed a wide linear response with the detection limits of 0.077­(0.6–620 μM) and 0.144­(0.2–460 μM) for the simultaneous detection of UA and G, respectively.

Nanostructured wearable electrochemical and biosensor towards healthcare management: a review

“…H. Liu et al 102 showed that the polymer of cellulose (CLC), which is dissolved in [BMIM]Cl, and combined with different functional groups such as –NH 2 , –SH – grafted poly(3,4-ethylene dioxythiophene) (PEDOT), i.e. , PEDOT-MeNH 2 /CLC and PEDOT-MeSH/CLC electrode might be very useful for the detection of guanine (G) and uric acid (UA), respectively, with good selectivity and detection limits.…”

Novel ratiometric electrochemical sensing platform for uric acid based on electroactive cuprous oxide nanocubes combined with boron carbide

“…Electrochemical methods have unique advantages in the detection of UA due to their advantages of low cost, simple operation, fast response, and high sensitivity. However, in the traditional electrochemical sensing platform, 8 most of the target detection is realized by one single-output signal, which makes the detection results easily affected by various factors, such as the environment, thus affecting the accuracy of the results. Ratiometric sensing technology 9,10 employs two signals during the detection, which can effectively reduce the influence caused by factors such as the environment and significantly exclude detection errors and increase the reliability of detection.…”