Carboxylesterase expression in human dental pulp cells: Role in regulation of BisGMA-induced prostanoid production and cytotoxicity

Chang, Mei‐Chi; Lin, Li‐Deh; Chuang, Fu-Hsiung; Chan, Chiu‐Po; Wang, Tong-Mei; Lee, Jang‐Jaer; Jeng, Po-Yuan; Tseng, Wan-Yu; Lin, Huei‐Jeng; Jeng, Jiiang‐Huei

doi:10.1016/j.actbio.2011.09.011

Cited by 60 publications

(41 citation statements)

References 37 publications

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“…Higher water solubility always leads to worse biocompatibility. 31 Therefore, water sorption and solubility of dental materials should not be high. The water sorption and solubility of UDMA/SR833s polymer were lower than those of Bis-GMA/TEGDMA and UDMA/TEGDMA polymers, and it might be an advantage of the UDMA/SR833s resin system that it is used as a dental resin.…”

Section: Discussionmentioning

confidence: 99%

Bis‐GMA Free Dental Materials Based on UDMA/SR833s Dental Resin System

Ding

Wang

et al. 2016

Adv Polym Technol

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ABSTRACT:Tricyclododecane dimethanol diacrylate (SR833s) was used to replace triethylene glycol dimethacrylate (TEGDMA) as a diluent monomer and mixed with 1,6-bis(methacryloxy-2-ethoxy-carbonylamino)-2,4,4-trimethylhexane (UDMA) to prepare 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropyl)-phenyl]propane (Bis-GMA) free dental resin system, and commonly used BaAlSiO 2 dental microfillers were added into UDMA/SR833s resin to prepare Bis-GMA free dental composites. Physicochemical properties such as double bond conversion, polymerization shrinkage, water sorption and solubility, flexural strength, and modulus of UDMA/SR833s resin and relevant composites were investigated. The results showed that UDMA/SR833s resin had better physicochemical properties than UDMA/TEGDMA and Bis-GMA/TEGDMA resins. Although UDMA/SR833s-based composites had lower flexural strength and modulus than commercial dental composite Z250, they still met the International Organization for Standardization (ISO) standard requirement (in flexural strength and modulus for resin-based dental materials). Except for the flexural strength and modulus, all the other properties of UDMA/SR833s-based composites were comparable or better than those of Z250. Therefore, UDMA/SR833s resin and its relevant composites had potential to be used in dentistry as Bis-GMA free dental materials. C

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Section: Discussionmentioning

confidence: 99%

Bis‐GMA Free Dental Materials Based on UDMA/SR833s Dental Resin System

Ding

Wang

et al. 2016

Adv Polym Technol

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“…The release of monomers is the main source of cytotoxicity and tissue inflammation [43]. It was reported that WSL was correlated with DC, and higher DC could lead to lower WSL [44]. However, compared with Bis-GMA-based resin, FDMA-based resin had higher WSL, though it had higher DC.…”

Section: Discussionmentioning

confidence: 99%

Preparation of a Bis-GMA-Free Dental Resin System with Synthesized Fluorinated Dimethacrylate Monomers

Luo

Zhu

Liu

et al. 2016

IJMS

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With the aim of reducing human exposure to Bisphenol A (BPA) derivatives in dentistry, a fluorinated dimethacrylate monomer was synthesized to replace 2,2-bis[4-(2-hydroxy-3-methacryloy-loxypropyl)-phenyl]propane (Bis-GMA) as the base monomer of dental resin. After mixing with reactive diluent triethyleneglycol dimethacrylate (TEGDMA), fluorinated dimethacrylate (FDMA)/TEGDMA was prepared and compared with Bis-GMA/TEGDMA in physicochemical properties, such as double bond conversion (DC), volumetric shrinkage (VS), water sorption (WS) and solubility (WSL), flexural strength (FS) and modulus (FM). The results showed that, when compared with Bis-GMA based resin, FDMA-based resin had several advantages, such as higher DC, lower VS, lower WS, and higher FS after water immersion. All of these revealed that FDMA had potential to be used as a substitute for Bis-GMA. Of course, many more studies, such as biocompatibility testing, should be undertaken to prove whether FDMA could be applied in clinic.

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“…The released monomers may lead to cytotoxicity and induce tissue inflammatory response of dental pulp and adjacent tissues. 32 Because of the potential problems induced by WS and water solubility, dental restorative materials should not have high WS and water solubility. The benefits of SiMA-containing polymers were that they had lower WS than Bis-GMA/TEGDMA control polymer and their water solubility was not higher than that of Bis-GMA/TEGDMA control polymer.…”

Section: Discussionmentioning

confidence: 99%

Preparation and Characterization of Low Polymerization Shrinkage and Bis‐GMA‐Free Dental Resin System

Yuan

Liu

2015

Adv Polym Technol

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ABSTRACT:Because of the estrogenic effect of bisphenol A (BPA), the application of BPA derivatives such as Bis-GMA in dentistry has been doubted. In this research, Bis-GMA-free dental resin systems were prepared by mixing 1,6-bis(2 -methacryloyoxy-ethoxycarbonyl-amino)-2,4,4-trimethylhexane (UDMA), silicon containing dimethacrylate monomer (SiMA), and triethyleneglycol dimethacrylate (TEGDMA) together with different mass fraction. Double bond conversion, polymerization shrinkage, flexural strength, flexural, water sorption, and water solubility of prepared resins were investigated. Results showed that when UDMA/SiMA/TEGDMA was present in the ratio of 9:1:10 (wt/wt/wt), the obtained resin had the best comprehensive physicochemical properties and potential to be used as Bis-GMA-free dental resin. C

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Carboxylesterase expression in human dental pulp cells: Role in regulation of BisGMA-induced prostanoid production and cytotoxicity

Cited by 60 publications

References 37 publications

Bis‐GMA Free Dental Materials Based on UDMA/SR833s Dental Resin System

Bis‐GMA Free Dental Materials Based on UDMA/SR833s Dental Resin System

Preparation of a Bis-GMA-Free Dental Resin System with Synthesized Fluorinated Dimethacrylate Monomers

Preparation and Characterization of Low Polymerization Shrinkage and Bis‐GMA‐Free Dental Resin System

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