Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery

Kaur, Harmanmeet; Ahuja, Munish; Kumar, Sandeep; Dilbaghi, Neeraj

doi:10.1016/j.ijbiomac.2011.11.017

Cited by 117 publications

(45 citation statements)

References 36 publications

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“…[103][104][105][106][107] The high viscosity and mucoadhesive property of tamarind seed polysaccharide make it as a suitable excipient in various ocular formulations for increasing the residence time for various drugs on the cornea. A tamarind gum based in situ gelling ocular dosage form of pilocarpine was developed and evaluated for its miotic potential.…”

Section: Ocular Drug Deliverymentioning

confidence: 99%

“…In another investigation, carboxymethyl-modified tamarind kernel polysaccharide was employed to develop ocular nanoparticles containing tropicamide. 107 These nanoparticles were formulated by ionotropic-gelation and optimized Figure 11. The optimized tropicamide-loaded carboxymethyl tamarind kernel polysaccharide nanoparticles showed ex-vivo corneal permeation of tropicamideacross isolated goat cornea comparable to its aqueous solution.…”

Section: Ocular Drug Deliverymentioning

confidence: 99%

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Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Nayak¹,

Pal²

2017

IJPER

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Currently, various plant polysaccharides have been studied for their diverse applications as excipients like binders, granulating agents, disintegrants, emulsifiers, suspending agents, gelling agents, mucoadhesive agents, matrix-formers, release retardants, enteric resistants, etc., in various pharmaceutical dosage forms. Among these, tamarind seed polysaccharide is an emerging excipient, which is beingused and investigated for the preparation of various dosage forms like suspensions, emulsions, tablets, gels, creams, beads, spheroids, microparticles, nanoparticles, ophthalmic preparations, and buccal patches, etc. The current chapter deals with a comprehensive and useful discussion on pharmaceutical applications of tamarind seed polysaccharide withits some important features like source, isolation, chemical composition and properties.

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Section: Ocular Drug Deliverymentioning

confidence: 99%

Section: Ocular Drug Deliverymentioning

confidence: 99%

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Nayak¹,

Pal²

2017

IJPER

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“…This colloidal dispersion was filtered through 0.45µm whatman's filter paper and then diluted with freshly prepared phosphate buffer pH 7.4 and measured the absorbance using UV spectrophotometer at 254 nm. The actual amount of drug present in prepared microspheres was calculated 11,21 .…”

Section: Determination Of Entrapment Efficiencymentioning

confidence: 99%

“…It blocks receptor in the muscles of the eye and control the size of pupil and lens shape. Tropicamide produces mydriasis due to blockage of receptors 11 . It has the fastest (25-45 min.)…”

Section: Introductionmentioning

confidence: 99%

Chitosan Loaded Microspheres of Tropicamide as Controlled Release of Drug for Ocular Drug Delivery System

Saini¹,

Kumar²,

Choudhary³

et al. 2017

Int. Res. J. Pharm.

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Ocular drug delivery via conventional eye drop is a convenient route of administration but it has serious limitations due to rapid clearance of the formulation from the eye. This study aimed to prepare and evaluate the sustained/controlled release of tropicamide microspheres with chitosan to increase ocular residence time of drug and also improve the bioavailability. The tropicamide loaded chitosan microspheres were prepared by ionic gelation technique using different ratios of polymer i.e. chitosan and cross-linking polymer i.e. sodium TPP. Microspheres were optimized by employing (2 2 ) factorial design and evaluated for particle size, entrapment efficiency, surface morphology and drug release profile. The entrapment efficiency was found to be higher with increase in the chitosan concentration. The increasing concentration of chitosan also showed the sustained release effect on the drug release. The optimized formulation showed the smooth morphology and average particle size was found to be about 15µm.The in-vitro release profile of tropicamide loaded microspheres showed a sustained release pattern as compared to pure drug. The results revealed that microspheres would be the promising candidates for enhancing the residence time by mucoadhesion which leads to enhancement of bioavailability of the tropicamide drug.

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“…It is cheap and biocompatible polysaccharide used as emulsifier, suspending, gelling and binding agent [6,13]. TG has some disadvantages like unpleasant odor, dull color and fast degradation [14]. To overcome these problems carboxymethylation of TG is done [15].…”

Section: Introductionmentioning

confidence: 99%

Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac

Mali¹,

Dhawale²,

Dias³

et al. 2017

mpj

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The aim of present investigation was to characterize carboxymethyl tamarind gum (CMTG) based interpenetrating networks (IPNs) of aceclofenac for site specific sustained delivery. The drug loaded IPNs were prepared by using chitosan and CMTG as polymers and gluteraldehyde as crosslinking agent. The IPNs were characterized by Attenuated total reflectanceFourier transform infrared (ATR-FTIR) spectroscopy, thermal analysis, X-ray powder diffraction and solid state 13 C-nuclear magnetic resonance spectroscopy. The prepared IPNs were evaluated for the drug entrapment efficiency and equilibrium swelling. The drug release from IPNs was studied in 0.1NHCl for 2h followed by phosphate buffer pH 6.8 for further 10h and compared with commercial tablet. The results of ATR-FTIR and thermal analysis for blank IPNs indicated intercalation of polymeric chains of crosslinked CMTG and chitosan. The results of solid state characterization revealed that the aceclofenac is compatible with IPNs. Entrapment efficiency of IPNs was found to be increased with increase in crosslinker concentration as well as amount of CMTG. The equilibrium swelling study indicated pH dependent swelling of IPNs. The drug release by IPNs showed sustained release of aceclofenac upto 12h while commercial formulation showed fast release within 8h. From the results, it can be concluded that the IPNs of CMTG and chitosan has potential in development of site specific sustained drug delivery.

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Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery

Cited by 117 publications

References 36 publications

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Chitosan Loaded Microspheres of Tropicamide as Controlled Release of Drug for Ocular Drug Delivery System

Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac

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