Carboxymethyl Tamarind Seed Kernel Polysaccharide Formulated into Pellets to Target at Colon

Abstract

Objective: Tamarind seed polysaccharide (TSP) modifying to carboxymethyl tamarind seed kernel polysaccharide (CMTSP) could be potential polymer over synthetic one to target colon diseases. Ibuprofen was loaded in CMTSP to achieve colon targeted sustained action of pellets due to viscous nature of CMTSP. Methods: Ibuprofen loaded CMTSP pellets prepared by extrusion spheronization technique were optimized using three-level two-factor full factorial design. Results: Higher was the amount of CMTSP; better was the crushing strength of pellets, needed to target at the colon. in vitro dissolution test of the pellets at pH 1.2, 6.8 and 7.4 phosphate buffer showed drug release within 10 h. Further, the effect of enzyme induced in the colon portion of rat, in response to fed CMTSP and TSP, was carried out by performing dissolution study of pellets at 2 and 4% w/v of rat caecal matter in an anaerobic environment. The optimal calculated parameters were CMTSP and MCC, each at 300 mg, with highest crushing strength (23.6 N) and drug release (98%) within 9 h in presence of rat caecal content (4% w/v). Scanning electron microscopy revealed the spherical nature of pellets with rough surface and small pore openings for the drug release. Conclusion: Ibuprofen loaded pellets of CMTSP were successfully targeted at colon, due to increase in viscosity and decrease in swelling index of CMTSP than TSP.

Delivery of drugs using tamarind gum and modified tamarind gum: A review

“…Ibuprofen [115] Pellets Extrusion spheronization CMTG-MCC Carrier NA TG-tamarind gum; MCC-microcrystalline cellulose; NA-not applicable Table 7 summarizes the application of TG and CMTG in microbead formulations. TG is used for the development of pH-sensitive microbeads in combination with SA [116] , gellan gum [117] and pectin [118] .…”

Deployment of the natural magnifier CMTKG for naked expansion microscopy of biological tissues

“…Addition of carboxymethyl groups also enhances TKG's shelf life by endowing resistance to enzymatic degradation. Moreover, the modified structure of carboxymethyl galactoxyloglucan offers benefits for sustained release, suggesting its potential as a drug carrier [15][16][17][18][19][20] .…”

Carboxymethyl Tamarind Kernel Gum Nanoparticles; As an Antioxidant Activity

“…Tamarind is a tropical evergreen tree native to India and other parts of the world. India is currently the world's largest tamarind producer [11]. Carboxymethyl tamarind kernel gum (CMTKG) is an anionic water-soluble polymer derived from Tamarind Kernel Powder (TKP) that undergoes a chemical reaction to make it cold water soluble (Carboxymethylation).…”