Carcinogenics and Growth Stimulation

Owen, Seward E.; Weiss, H. A.; Prince, Lillian

doi:10.1126/science.87.2255.261

Cited by 9 publications

(1 citation statement)

References 5 publications

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“…The planarian model system, with a recently sequenced genome ( Schmidtea mediterranea ) and well-developed molecular and genetic tools, has great potential to significantly contribute in these areas [30, 33–35, 63, 66, 68–70]. Unlike other invertebrate models, planarians have historically been extensively used to test diverse pharmacological and carcinogenic compounds in both whole (non-regenerating) and regenerating adult animals [20, 29, 36–38, 41, 42, 71]. Results from several studies concluded neoblasts bear a functional resemblance to both adult mammalian stem cells and early-stage embryonic cells; particularly, neoblasts respond to carcinogenic agents by forming benign and malignant tumors, as well as teratomas [20, 36–38, 41].…”

Section: Planarian Regeneration and Cancermentioning

confidence: 99%

Regeneration: The origin of cancer or a possible cure?

Oviedo

Beane

2009

Seminars in Cell & Developmental Biology

126

102

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A better understanding of the forces controlling cell growth will be essential for developing effective therapies in regenerative medicine and cancer. Historically, the literature has linked cancer and tissue regeneration—proposing regeneration as both the source of cancer and a method to inhibit tumorigenesis. This review discusses two powerful regeneration models, the vertebrate urodele amphibians and invertebrate planarians, in light of cancer regulation. Urodele limb and eye lens regeneration is described, as well as the planarian’s emergence as a molecular and genetic model system in which recent insights begin to molecularly dissect cancer and regeneration in adult tissues.

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