Carcinoma hepatocelular

Pérez, Leticia; López, Sonia Alonso; Fajes, José Luis Herrera; Martín, Laura Serrano

doi:10.1016/j.med.2020.06.019

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…The majority of HCC cases are primarily caused by hepatitis B or C infection [1]. However, various other reasons have been identified, including alcohol consumption, oxidative stress, toxic materials, and food carcinogens such as aflatoxins and nitrosamines [2]. The most common methods for treating HCC are radiation and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Encapsulated Apigenin Nanoparticles on HePG-2 Cells through Regulation of P53

et al. 2022

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Apigenin (Ap) is one of the most important natural flavonoids that has potent anticancer activity. This study was designed, for the first time, to load Ap into chitosan to improve its hydrophobicity and then it was coated with albumin-folic acid to increase its stability and bioavailability and to target cancer cells. The newly developed encapsulated Ap (Ap-CH-BSA-FANPs) was characterized and tested in vitro. The zeta potential of −17.0 mV was within the recommended range (−30 mV to +30 mV), indicating that encapsulated apigenin would not quickly settle and would be suspended. The in vitro results proved the great anticancer activity of the encapsulated apigenin on HePG-2 cells compared to pure Ap. The treated HePG-2 cells with Ap-CH-BSA-FANPs demonstrated the induction of apoptosis by increasing p53 gene expression, arresting the cell cycle, increasing caspase-9 levels, and decreasing both the MMP9 gene and Bcl-2 protein expression levels. Moreover, the higher antioxidant activity of the encapsulated apigenin treatment was evident through increasing SOD levels and decreasing the CAT concentration. In conclusion, the Ap-CH-BSA-FANPs were easy to produce with low coast, continued drug release, good loading capacity, high solubility in physiological pH, and were more stable than the formerly Ap-loaded liposomes or PLGA. Moreover, Ap-CH-BSA-FANPs may be a promising chemotherapeutic agent in the treatment of HCC.

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Section: Introductionmentioning

confidence: 99%

The Effect of Encapsulated Apigenin Nanoparticles on HePG-2 Cells through Regulation of P53

et al. 2022

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“…Errors in genetic transcription or translation affect cellular function and performance, thus causing cells to become cancerous [4][5][6][7][8]. Due to its widespread nature and huge mortality rate, it is of utmost importance to focus on treatment strategies that can help minimize the formation and progression of carcinomas [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Novel Green Approaches for the Preparation of Gold Nanoparticles and Their Promising Potential in Oncology

et al. 2022

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The difficulty of achieving targeted drug delivery following administration of currently marketed anticancer therapeutics is a still a concern. Metallic nanoparticles (NPs) developed through nanotechnology breakthroughs appear to be promising in this regard. Research studies pertaining to gold NPs have indicated their promising applicability in cancer diagnosis, drug delivery and therapy. These NPs have also recently paved the path for precise drug delivery and site-specific targeting. Our review paper thus highlights the scope and impact of biogenetically generated gold nanoparticles (NPs) in cancer therapy. In a critical, constructive, and methodical manner, we compare the advantages offered by gold NPs over other metal NPs. Moreover, we also focus on novel ‘greener’ strategies that have been recently explored for the preparation of gold NPs and shed light on the disadvantages of conventional NP synthesis routes. Future prospects pertaining to the use of gold NPs in oncotherapy and domains that require further investigation are also addressed.

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“…Hepatocellular carcinoma (HCC) is one of the most common malignant diseases and is becoming more and more globally at increasingly young ages 1 .…”

Section: Introductionmentioning

confidence: 99%

“…More than 800,000 people are diagnosed with this cancer each year. Liver cancer is also the leading cause of cancer deaths worldwide, accounting for over 700,000 deaths every year 1 .…”

Section: Introductionmentioning

confidence: 99%

Study on Preparation of Y-90 Microspheres in Da Lat Nuclear Reactor for Application in Treatment of Primary and Secondary Liver Cancers

Minh¹,

Dong²,

Thuan³

et al. 2020

Orient. J. Chem

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In this article, Y-90 microspheres are synthesized in three forms (resin microspheres, glass microspheres and gel microspheres) in Da Lat Nuclear Reactor (Vietnam) with a capacity of 500 kW for application in treatment of primary and secondary liver cancers. Characterization and quality of Y-90 microspheres are checked by field emission scanning electron microscopy (FE-SEM), energydispersive X-ray spectroscopy (EDX), chemical purity, radionuclide purity, radiochemical purity, sterility, bacterial endotoxins, toxic heavy metals (ICP-MS) and product stability over time. The results showed that Y-90 resin microspheres, Y-90 glass microspheres and Y-90 gel microspheres with particle sizes of 20-30 µm have a high specific activity to meet the quality standards of radiopharmaceuticals according to British Pharmacopoeia 2016. This is a promising radiopharmaceuticals in treatment of primary and secondary liver cancers using radioembolization in Vietnam.

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Carcinoma hepatocelular

Cited by 5 publications

References 42 publications

The Effect of Encapsulated Apigenin Nanoparticles on HePG-2 Cells through Regulation of P53

The Effect of Encapsulated Apigenin Nanoparticles on HePG-2 Cells through Regulation of P53

Novel Green Approaches for the Preparation of Gold Nanoparticles and Their Promising Potential in Oncology

Study on Preparation of Y-90 Microspheres in Da Lat Nuclear Reactor for Application in Treatment of Primary and Secondary Liver Cancers

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