Carcinoma hepatocelular en hígado no cirrótico: características clínicas y resultados en Veracruz, México

Martínez-Mier, Gustavo; Esquivel-Torres, S.; Casanova-Sánchez, Iván Eliud; Escobar-Ríos, A.Y.; Troche-Gutiérrez, J.M.; Yoldi-Aguirre, C.A.

doi:10.1016/j.rgmx.2019.11.007

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Unfortunately, NCHCC lesions are usually large due to their late diagnosis[ 102 ]. Long-term overall survival (OS) after hepatic resection for NCHCC showed an OS rate of 62%-100% (1 year), 46%-78% (3 year) and 30%-64% (5 year)[ 103 , 104 ]. Multiple synchronous lesions, large tumor size, non-clear resection margin, poor tumor staging and lymphatic invasion were indicators of poor prognosis[ 104 ].…”

Section: Treatmentmentioning

confidence: 99%

“…Long-term overall survival (OS) after hepatic resection for NCHCC showed an OS rate of 62%-100% (1 year), 46%-78% (3 year) and 30%-64% (5 year)[ 103 , 104 ]. Multiple synchronous lesions, large tumor size, non-clear resection margin, poor tumor staging and lymphatic invasion were indicators of poor prognosis[ 104 ]. Subject to the presence of adequate future liver remnant, these patients may undergo repeat resections.…”

Section: Treatmentmentioning

confidence: 99%

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Non-cirrhotic hepatocellular carcinoma in chronic viral hepatitis: Current insights and advancements

Perisetti

Goyal

Thandassery

et al. 2021

WJG

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Primary liver cancers carry significant morbidity and mortality. Hepatocellular carcinoma (HCC) develops within the hepatic parenchyma and is the most common malignancy originating from the liver. Although 80% of HCCs develop within background cirrhosis, 20% may arise in a non-cirrhotic milieu and are referred to non-cirrhotic-HCC (NCHCC). NCHCC is often diagnosed late due to lack of surveillance. In addition, the rising prevalence of non-alcoholic fatty liver disease and diabetes mellitus have increased the risk of developing HCC on non-cirrhotic patients. Viral infections such as chronic Hepatitis B and less often chronic hepatitis C with advance fibrosis are associated with NCHCC. NCHCC individuals may have Hepatitis B core antibodies and occult HBV infection, signifying the role of Hepatitis B infection in NCHCC. Given the effectiveness of current antiviral therapies, surgical techniques and locoregional treatment options, nowadays such patients have more options and potential for cure. However, these lesions need early identification with diagnostic models and multiple surveillance strategies to improve overall outcomes. Better understanding of the NCHCC risk factors, tumorigenesis, diagnostic tools and treatment options are critical to improving prognosis and overall outcomes on these patients. In this review, we aim to discuss NCHCC epidemiology, risk factors, and pathogenesis, and elaborate on NCHCC diagnosis and treatment strategies.

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