Carcinoma of the Lungs Causing Enlarged Kidneys

Srisung, Weeraporn; Mankongpaisarnrung, Charoen; Warraich, Irfan; Sotello, David; Yarbrough, Shannon; Laski, Melvin E.

doi:10.1080/08998280.2015.11929235

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…The most common form of metastatic renal carcinomas is multiple bilaterally circumscribed, rounded masses ( 35 ). In patients with known primary tumors, diffuse enlargement of the kidney without a clear mass may suggest renal metastatic disease ( 38 ). In this case, the imaging findings were bilaterally enlarged kidneys without focal lesions.…”

Section: Discussionmentioning

confidence: 99%

Untypical bilateral breast cancer with peritoneal fibrosis on 18F-FDG PET/CT: case report and literature review

Song,

Qiu,

Huang

et al. 2024

Front. Med.

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BackgroundRetroperitoneal fibrosis, a condition of uncertain origin, is rarely linked to 8% of malignant cases, including breast, lung, gastrointestinal, genitourinary, thyroid, and carcinoid. The mechanism leading to peritoneal fibrosis induced by tumors is not well understood, possibly encompassing direct infiltration of neoplastic cells or the initiation of inflammatory responses prompted by cytokines released by tumor cells. We report a case of breast cancer with renal metastasis and retroperitoneal fibrosis detected using 18F-FDG PET/CT, providing help for clinical diagnosis and treatment.Case reportA 49-year-old woman was referred to the hospital with elevated creatinine and oliguria for over a month. Abdominal computer tomography (CT) and magnetic resonance imaging (MRI) showed a retroperitoneal fibrosis-induced acute kidney injury (AKI) was suspected. However, a percutaneous biopsy of the kidney lesion confirmed metastasis from breast cancer. The physical examination revealed inverted nipples and an orange peel appearance on the skin of both breasts. Ultrasonography revealed bilateral hyperplasia (BIRADS 4a) of the mammary glands and bilateral neck and axillary lymphadenopathy. Subsequently, 18F-deoxyglucose positron emission tomography/computer tomography (18F-FDG PET/CT) detected abnormally high uptake (SUVmax) in the bilateral mammary glands and axillary lymph nodes, suggesting bilateral breast cancer. Furthermore, abnormal 18F-FDG uptake was detected in the kidney, suggesting renal metastasis. In addition, abnormal 18F-FDG uptake was observed in the vertebrae, accompanied by an elevation in inhomogeneous bone mineral density, raising suspicion of bone metastases. However, the possibility of myelodysplasia cannot be dismissed, and further investigations will be conducted during close follow-ups. There was significant 18F-FDG uptake in the retroperitoneal position indicating a potential association between retroperitoneal fibrosis and breast cancer. The final pathological diagnosis of the breast tissue confirmed bilateral invasive ductal carcinoma. The patient had been treated with 11 cycles of albumin-bound (nab)-paclitaxel (0.3 mg) and had no significant adverse reaction.ConclusionIn this case, neither the bilateral breast cancer nor the kidney metastatic lesion showed typical nodules or masses, so breast ultrasound, abdominal CT, and MRI did not suggest malignant lesions. PET/CT played an important role in detecting occult metastases and primary lesions, thereby contributing to more accurate staging, monitoring treatment responses, and prediction of prognosis in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Untypical bilateral breast cancer with peritoneal fibrosis on 18F-FDG PET/CT: case report and literature review

Song,

Qiu,

Huang

et al. 2024

Front. Med.

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“…The lung represents the main primary site for renal metastasis in the majority of studies; the incidence of renal metastases from a lung primary in clinical series is estimated between 26% and 46.5% 4–6,27,28. All different histologic types of lung carcinoma can metastasize to the kidney 22,29–48. In a Japanese series, Ichimatsu et al49 reviewed 64 cases of metastatic renal tumors originating from a lung primary and documented that the histologic subtypes were 57.6% squamous cell carcinoma, 28.8% adenocarcinoma, and 5.1% small cell carcinoma.…”

Section: Primary Tumor Sitesmentioning

confidence: 99%

“…[4][5][6]27,28 All different histologic types of lung carcinoma can metastasize to the kidney. 22,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] In a Japanese series, Ichimatsu et al 49 reviewed 64 cases of metastatic renal tumors originating from a lung primary and documented that the histologic subtypes were 57.6% squamous cell carcinoma, 28.8% adenocarcinoma, and 5.1% small cell carcinoma. Wu et al 4 documented adenocarcinoma (55%), and Huang et al 5 noted squamous cell carcinoma (68%) as the most common histologic types to metastasize to the kidney in their series.…”

Section: Lungmentioning

confidence: 99%

Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

Saeed

Osunkoya²

2022

Advances in Anatomic Pathology

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Metastases to the kidney are rare and were historically described in autopsy series, and the incidence ranged between 2.36% and 12.6%. However, in the contemporary literature with the improvements in imaging modalities (computed tomography scan and magnetic resonance imaging) and other health care screening services, metastatic tumors to the kidney are being diagnosed more frequently in surgical specimens. The utility of needle core biopsies in the primary evaluation of renal masses has also increased the number of sampled metastases, and as a result, only limited histologic material is available for evaluation in some cases and may potentially lead to diagnostic pitfalls. In the last decade, a few large clinical series have been published. In these series, the majority of metastatic tumors to the kidney are carcinomas, with the lung being the most common primary site. A significant number of the various tumor types with metastasis to the kidney are also associated with widespread metastases to other organs, and the renal metastasis may present several years after diagnosis of the primary tumor. The majority of secondary tumors of the kidney are asymptomatic, incidentally discovered, and solitary. There should be a high index of suspicion of metastasis to the kidney in patients with an associated enlarging renal lesion with minimal to no enhancement on imaging and tumor progression of a known high-grade nonrenal malignancy. Secondary tumors of the kidney can be accurately diagnosed by correlating histopathologic features with clinical and radiographic findings and the judicious use of ancillary studies.

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