Carcinome à petites cellules du poumon et syndrome néphrotique d’évolution rapidement fatale

Yangui, I.; Msaad, S.; Smaoui, M.; Makni, Saadia; Kammoun, K.; Khebir, Abedelmajid; Boudawara, Tahia; Ayoub, A.

doi:10.1016/s0761-8417(07)74212-8

Cited by 9 publications

(3 citation statements)

References 12 publications

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“…La glomérulonéphrite extra-membraneuse constitue l'étiologie la plus fréquente des syndromes néphrotiques paranéoplasiques et ce dans 75% des cas [5,8] [2,9]. La pathogénie du syndrome néphrotique paranéoplasique n'est pas encore bien établie [10]. La production d'antigènes tumoraux provoquant la formation de complexes immuns et leur déposition au niveau de la membrane basale glomérulaire auraient pour conséquence l'activation d'un complexe d'attaque membranaire responsable de l'altération de celle-ci [11].…”

Section: Discussionunclassified

Nephrotic Syndrome Revealing of a Squamous Cell Bronchial Carcinoma

Sbiki¹,

Lefqih²,

Taoufiq³

et al. 2022

ATD

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Malignant broncho-pulmonary tumors are the principal cause of the paraneoplastic nephrotic syndrome. These tumors are most often small cell or squamous bronchial carcinomas. In 75% of cases, the nephrotic syndrome is due to membranous glomerulonephritis. We report the case of a 67 years old patient, a chronic tobacco user, followed since June 2019 for a nephrotic syndrome caused by extra-membranous glomerulonephritis. A chest computed tomography revealed a mass of the left lower lobe. Trans-parietal biopsy of this process revealed a squamous bronchial carcinoma. PET scan detected no other fixations. The proteinemia was at 39g/l with albuminemia at 14 g/l. Surgical resection was then indicated and the patient underwent a left lower lobectomy with radical lymph adenectomy. Outcomes were simple with complete resolution of paraneoplastic nephrotic syndrome.

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Section: Discussionunclassified

Nephrotic Syndrome Revealing of a Squamous Cell Bronchial Carcinoma

Sbiki¹,

Lefqih²,

Taoufiq³

et al. 2022

ATD

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“…There are 49 cases of tumor-related MGN in the literature, including nine cases of SCLC (29). One study reported a case of SCLC without metastases discovered by a paraneoplastic nephrotic syndrome (30). The complete remission of cancer was achieved by chemotherapy and radiotherapy with the resolution of nephrotic syndrome, while tumor progression occurred at the same time with fatal renal failure (30).…”

Section: Introductionmentioning

confidence: 99%

“…One study reported a case of SCLC without metastases discovered by a paraneoplastic nephrotic syndrome (30). The complete remission of cancer was achieved by chemotherapy and radiotherapy with the resolution of nephrotic syndrome, while tumor progression occurred at the same time with fatal renal failure (30). It was also detected in one case of isolated unilateral renal metastases which was induced by lung cancer (31).…”

Section: Introductionmentioning

confidence: 99%

Lung cancer and kidney injury: an updated review

et al. 2020

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Lung cancer is the leading cause of cancer deaths worldwide, accounting for an estimated 1.8 million deaths. Lung cancer is also the most common primary cancer leading to soft tissue (ST) metastasis. Renal disease may occur as a direct or indirect consequence of the cancer itself (e.g., postrenal obstruction, compression, or infiltration), its treatment (e.g., radiotherapy or chemotherapy), or its related complications (e.g., opportunistic infection). Existing evidence shows that the most frequent primary solid tumor responsible for renal metastasis is pulmonary carcinoma, followed by gastric, breast, soft tissue, and thyroid carcinomas. Chronic kidney disease is a potential risk factor in the survival of patients with lung cancer. In this review, we will discuss causes of kidney injury in relation to lung cancer, potential mechanisms of kidney injury, and treatment options.

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