Carcinome sarcomatoïde du côlon : présentation d’un cas et revue de la littérature

Macaigne, Gilles; Aouad, K.; Boivin, Jean‐François; Bellaïche, Annie; Picard, D; Deplus, Renaud

doi:10.1016/s0399-8320(04)95018-x

Cited by 17 publications

(6 citation statements)

References 14 publications

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“…Carcinosarcoma is widely considered a rare, highly aggressive tumour. Carcinosarcoma of the colon was first reported by Weidner et al in 1986 [ 9 ] and to the best of our knowledge, cases of colon carcinosarcomas and sarcomatoid carcinomas reported in literature are 17 [ 4 , 9 ][ 10 - 12 ][ 13 - 15 ][ 16 - 18 ][ 19 - 21 ][ 22 - 24 ], summarised in Table 3 . Affected patients show an age between 41 and 84 years, with a median age of 66 years and a slight predilection for women.…”

Section: Case Presentationmentioning

confidence: 99%

Carcinosarcoma of the colon: report of a case with morphological, ultrastructural and molecular analysis

et al. 2006

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Section: Case Presentationmentioning

confidence: 99%

Carcinosarcoma of the colon: report of a case with morphological, ultrastructural and molecular analysis

et al. 2006

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“…We identified 50 previously reported cases of CRC with sarcomatoid components in our literature review, nearly always under the moniker of either carcinosarcoma or sarcomatoid carcinoma 4–53 . These are summarized in Supplemental Table 1, Supplemental Digital Content 1, http://links.lww.com/PAS/B738, though most cases were not published in the pathology literature, various clinicopathologic details were not available for most cases, and a few cases were not published in English or were not accessible.…”

Section: Resultsmentioning

confidence: 99%

“…Carcinoma with sarcomatoid components is extremely rare, with ~50 reported cases 4–53 and one National Cancer Database search 54 previously published in the literature, the former exclusively as single-case reports. These publications usually employed the term “carcinosarcoma” or “sarcomatoid carcinoma,” with the specific term “carcinoma with sarcomatoid components” not used in the literature before the 2019 publication of the latest WHO classification.…”

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confidence: 99%

Colorectal Carcinoma With Sarcomatoid Components

Golconda,

McHugh,

Allende

et al. 2023

American Journal of Surgical Pathology

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Colorectal carcinoma with sarcomatoid components (which includes so-called carcinosarcomas and sarcomatoid carcinomas) is a rare subtype with 50 reported cases in the literature and overlapping criteria with undifferentiated carcinoma. We collected and described 15 cases from 10 men and 5 women, with a mean age of 66 years. Symptoms included abdominal pain and gastrointestinal bleeding. Most tumors presented in the rectosigmoid region, with a mean size of 8.2 cm. The sarcomatoid component, on average, represented 58% of the tumors and took many forms, including spindled (10 cases), anaplastic (9 cases), and rhabdoid (3 cases); one case showed osteoid matrix. Tumor budding was usually high, and tumor-infiltrating lymphocytes were usually low. The sarcomatoid component was keratin-positive in 10 cases. One case showed loss of mismatch repair protein expression, and 2 cases showed SMARCA4 loss (1 also with SMARCA2 loss). Molecular testing identified mutations in KRAS (n=1), NRAS (n=2), BRAF (n=2), APC (n=1), and TP53 (n=1) in a few cases. Tumors often presented at advanced stage, with 11 cases pT4, 9 cases with nodal metastases, and 7 cases with distant metastases. Follow-up was available for 10 cases (median: 2 months), with 2 alive without disease, 3 alive with disease, and 5 dead. Our findings roughly corresponded with those in previously reported cases. Colorectal carcinoma with sarcomatoid components is rare and aggressive, with a poor prognosis for many patients. We suggest that spindled cells, anaplasia, heterologous elements, and/or a component with definable sarcomatous lineage be used to distinguish colorectal carcinoma with sarcomatoid components from undifferentiated carcinoma.

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“…The two distinct components are theorized to arise from a common progenitor based on molecular studies, but the exact pathogenesis and driver of the divergent phenotypes have not yet been well-characterized [2]. The adenocarcinoma component is known to stain positive for epithelial markers and various patterns of positive cytokeratin staining have been reported in colorectal carcinosarcoma [9,[13][14][15]. The sarcomatous component is often positive for vimentin, SMA and desmin.…”

Section: Discussionmentioning

confidence: 99%

An Unconventional Regimen of Carboplatin and Paclitaxel in Metastatic Colorectal Carcinosarcoma: A Case Report and Review of Literature

Park

Rajadurai

et al. 2023

Current Oncology

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Colorectal carcinosarcoma is an exceedingly rare subtype of colorectal cancer that displays the histological and molecular features of both mesenchymal and epithelial tumors. Due to its rarity, there are no guidelines regarding the systemic treatment of this disease. This report describes a case of a 76-year-old woman with colorectal carcinosarcoma with extensive metastatic burden treated with carboplatin and paclitaxel. After four cycles of chemotherapy, the patient had an excellent clinical and radiographical response to treatment. To the best of our knowledge, this is the first report addressing the use of carboplatin and paclitaxel in this disease. We reviewed seven published case reports of metastatic colorectal carcinosarcoma where various systemic treatments were offered. Remarkably, there are no previously published reports where even a partial response was noted, which underscores the aggressiveness of this disease. While further studies are required to validate our experience and assess long-term outcomes, this case suggests an alternative treatment regimen for metastatic colorectal carcinosarcoma.

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Carcinome sarcomatoïde du côlon : présentation d’un cas et revue de la littérature

Cited by 17 publications

References 14 publications

Carcinosarcoma of the colon: report of a case with morphological, ultrastructural and molecular analysis

Carcinosarcoma of the colon: report of a case with morphological, ultrastructural and molecular analysis

Colorectal Carcinoma With Sarcomatoid Components

An Unconventional Regimen of Carboplatin and Paclitaxel in Metastatic Colorectal Carcinosarcoma: A Case Report and Review of Literature

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