Carcinosarcoma is an aggressive subtype of bladder cancer: A <scp>population‐based</scp> study

Liu, Lin; Zhu, Jinglan; Tian, Yun

doi:10.1002/cam4.4611

Cited by 4 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of pulmonary and bladder CS, males played a dominant part with male‒female sex ratios of 4:1 and 2:1, respectively 16 29 30. Sex-related living habits (smoking and drinking) and biological differences (DNA damage susceptibility) may explain this preference.…”

Section: Discussionmentioning

confidence: 99%

“…In terms of pulmonary and bladder CS, males played a dominant part with male‒female sex ratios of 4:1 and 2:1, respectively. 16 29 30 Sex-related living habits (smoking and drinking) and biological differences (DNA damage susceptibility) may explain this preference. In contrast with non-small cell lung cancer, pulmonary CS presented a lower incidence of lymph node metastasis and a higher rate of surgical resection in our results.…”

Section: Discussionmentioning

confidence: 99%

“…12 Nonetheless, because of the anatomic diversity of origin in CS, previous studies based on the SEER database usually focused on a single organ, rendering the understanding of CS fragmentary and deficient. [13][14][15][16] This study intended to describe a standardised and systematic characterisation of demographical and clinicopathological peculiarities of CS across common locations compared with nonvariant histological subtypes.…”

Section: Open Accessmentioning

confidence: 99%

“…The Surveillance, Epidemiology and End Results (SEER) database, one of the population-based cancer registries, encompasses approximately 30% of the USA with widespread capture of different histological cases 12. Nonetheless, because of the anatomic diversity of origin in CS, previous studies based on the SEER database usually focused on a single organ, rendering the understanding of CS fragmentary and deficient 13–16. This study intended to describe a standardised and systematic characterisation of demographical and clinicopathological peculiarities of CS across common locations compared with nonvariant histological subtypes.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Epidemiology, site-specific characteristics and survival of carcinosarcoma: a retrospective study based on SEER database

Tang,

Zhou,

Wang

et al. 2023

BMJ Open

View full text Add to dashboard Cite

ObjectivesCarcinosarcoma (CS) is a rare and biphasic malignancy characterised by a highly invasive biological nature and poor prognosis. This study explored the epidemiology, site-specific characteristics and survival outcome of CS.DesignWe conducted a retrospective study in the Surveillance, Epidemiology and End Results (SEER) database (1975–2018) for primary CS.Setting and participantsSEER database includes publicly available information from regional and state cancer registries in the US centres. A total of 5042 CS patients were identified. We selected the top five anatomic CS (uterus, double adnexa, lung, bladder and breast) patients for further analysis.Primary outcome measuresIncidence was estimated by geographical region, age, sex, race, stage and primary site. Trends were calculated using joinpoint regression. The cancer-specific survival (CSS) rate and initial treatment were summarised.ResultsNearly 80% of CS occurred in the uterus and double adnexa, followed by lung, bladder and breast. The elderly and black population presented the highest age-adjusted rate of CS. The rates of distant metastasis in CS progressively increased from 1989 to 2018. Atlanta was the area with the highest incidence at 0.7 per 100 000. Pulmonary and bladder CS more frequently occurred in men and were diagnosed with regional stage. Distant metastasis was mostly found in ovary/fallopian tube CS. Radiotherapy was more commonly applied in uterine CS, while adnexa CS cases were more likely to receive chemotherapy. Multiple treatments were more used in breast CS. Pulmonary CS seemed to suffer worse CSS (median: 9.92 months), for which radiotherapy might not provide survival benefits (HR 0.60, 95% CI 0.42 to 0.86). Compared with the common histological types in each site, CS had the shortest survival.ConclusionsCS has unique clinical features in each primary site. Substantial prognosis variances exist based on tumour locations. The aggressive course is the common feature in CS at all sites.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Open Accessmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology, site-specific characteristics and survival of carcinosarcoma: a retrospective study based on SEER database

Tang,

Zhou,

Wang

et al. 2023

BMJ Open

View full text Add to dashboard Cite

show abstract

“…Carcinosarcoma is a rare biphasic tumor composed of both carcinoma and sarcoma elements; this is the most lethal malignancy (1)(2)(3). Carcinosarcoma occurs at various sites, mainly in the uterus and ovary, but also in the lung, bladder, peritoneum, and gallbladder (4)(5)(6)(7)(8)(9). Due to the highly aggressive behavior of carcinosarcomas, advanced stage at diagnosis and frequent recurrences may explain the poor prognosis (1,5,9).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and prediction model of patients with carcinosarcoma in the United States

Chen

Yang³

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

BackgroundCarcinosarcoma is a rare biphasic tumor composed of both carcinoma and sarcoma elements, which occurs at various sites. Most studies are case reports or small population-based studies for a single disease site, so comprehensive evaluations of epidemiology and prognostic factors for carcinosarcoma are needed.MethodsSurveillance, Epidemiology, and End Results (SEER)-8 (1975–2019) provided data for the epidemiological analysis. SEER-17 (2000–2019) provided data on the primary tumor sites, initial treatment, construction, and validation of the nomogram.ResultsThe age-adjusted incidence per 100,000 persons of carcinosarcoma increased significantly from 0.46 to 0.91 [1975–2019; average annual percent change (AAPC): 1.3%, P = 0.006], with localized stage increasing from 0.14 to 0.26 [2005–2015; annual percent change (APC): 4.2%]. The 20-year limited-duration prevalence per 100,000 increased from 0.47 to 3.36 (1999–2018). The mortality per 100,000 increased significantly from 0.16 to 0.51 (1975–2019; AAPC: 1.9%, P < 0.001). The 5-year relative survival was 32.8%. The greatest number of carcinosarcomas were from the uterus (68.7%), ovary (17.8%), lung and bronchus (2.3%). The main treatment is comprehensive treatment based on surgery; however, surgery alone is preferred in older patients. In multivariate analysis (N = 11,424), age, sex, race, year of diagnosis, disease stage, tumor site, and treatment were associated with survival. A nomogram was established to predict 1-, 3-, and 5-year survival, and the C-indexes were 0.732 and 0.748 for the training and testing sets, respectively. The receiver operating characteristic curve demonstrated that the nomogram provided a comprehensive and accurate prediction [1-year area under the curve (AUC): 0.782 vs. 0.796; 3-year AUC: 0.771 vs. 0.798; 5-year AUC: 0.777 vs. 0.810].ConclusionsIn this study, the incidence, prevalence, and mortality of carcinosarcoma have increased over the past decades. There was a rapid rise in the incidence of localized stage in recent years, which reflected improved early detection. The prognosis of carcinosarcoma remains poor, signifying the urgency of exploring targeted cancer control treatments. Explicating distribution and gender disparities of carcinosarcoma may facilitate disease screening and medical surveillance. The nomogram demonstrated good predictive capacity and facilitated clinical decision-making.

show abstract

Carcinosarcoma is an aggressive subtype of bladder cancer: A population‐based study

2022

Self Cite

View full text Add to dashboard Cite

Background Case reports of bladder carcinosarcoma (BCS) indicate high rates of recurrence and metastasis and poor prognosis. However, the differences in clinicopathologic characteristics and prognosis between BCS and conventional bladder cancer histologies (transitional cell carcinoma [TCC], squamous cell carcinoma [SCC] and adenocarcinoma [AC]) have not been fully clarified in a large study. Therefore, we conducted a large population‐based study to further investigate these differences. Patients and methods Information on patients with BCS and conventional bladder cancer (TCC, SCC or AC) was extracted from the Surveillance, Epidemiology, and End Results database. Categorical variables were compared using Pearson's chi‐squared test or Fisher's exact test. Survival analysis was carried out using the Kaplan–Meier method, and differences in survival were assessed using the log‐rank test. Propensity score matching analysis was conducted to calibrate the differences between the baseline characteristics, after which Cox regression analysis was applied to calculate the hazard ratios and 95% confidence intervals of BCS compared to other subtypes. Subgroup analysis and related interaction were tested to evaluate the consistency and heterogeneity of results. Results We enrolled 152 patients with BCS and 180,196 patients with TCC, SCC or AC. Our results showed that BCS was associated with poor differentiation, advanced stage and an unfavourable overall survival and cancer‐specific survival. BCS had a worse prognosis than TCC and AC, but no statistically significant difference in survival was noted between BCS and SCC. Conclusions BCS is a more aggressive bladder cancer than TCC and AC but is comparable to SCC. These findings broaden our understanding of BCS and may be helpful in clinical practice.

show abstract

Carcinosarcoma is an aggressive subtype of bladder cancer: A population‐based study

Cited by 4 publications

References 19 publications

Epidemiology, site-specific characteristics and survival of carcinosarcoma: a retrospective study based on SEER database

Epidemiology, site-specific characteristics and survival of carcinosarcoma: a retrospective study based on SEER database

Epidemiology and prediction model of patients with carcinosarcoma in the United States

Carcinosarcoma is an aggressive subtype of bladder cancer: A population‐based study

Contact Info

Product

Resources

About