Carcinostatic activity of thiosemicarbazones of formyl heteroaromatic compounds. VI. 1-Formylisoquinoline derivatives bearing additional ring substituents, with notes on mechanism of action

French, Frederic A.; Blanz, Erwin J.; DoAmaral, Jefferson R.; French, D. A.

doi:10.1021/jm00300a024

Cited by 123 publications

(31 citation statements)

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“…N,N-Dialkyl-N'-benzoyl thioureas act as selective complexing agents for the enrichment of platinum metals even from strongly interfering matrixes [19]. The complexes of thiourea derivatives also show various biological activities [20].…”

Section: Introductionmentioning

confidence: 99%

The crystal structure of 1-(4-chlorophenyl)-3-(4-methylbenzoyl)thiourea

Saeed

Parvez

2005

Open Chemistry

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1-(4-Chlorophenyl)-3-(4-methylbenzoyl)thiourea was synthesized and characterized by IR, 1 H and 13 C NMR, mass spectroscopy and the elemental analysis. The crystal structure was confirmed from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P2 1 /c with unit cell dimensions a = 12.038(3), b = 6.330(6), c = 18.912(5)Å and β = 100.32(3) • . There is a strong intramolecular hydrogen bond of the type N-H. . . O, with distance N1. . . O1 = 2.659(3)Å. The structure is composed of dimers related by inversion centers. The dimers are formed by intermolecular interactions of the type N-H. . . S with N. . . S separation of 3.440(2)Å. The mass fragmentation pattern has also been discussed.

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Section: Introductionmentioning

confidence: 99%

The crystal structure of 1-(4-chlorophenyl)-3-(4-methylbenzoyl)thiourea

Saeed

Parvez

2005

Open Chemistry

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“…These metal based complexes have attracted considerable interest in chemical and biological studies due to their potentially beneficial biocidal activity which may be attributed to formation of their chelates with metal ions [5][6][7][8][9][10] . Such promising biological potentials of Schiff base and its metal complexes as well as in continuation of our earlier research work [11][12][13] in this field we have prompted us synthesized complexes of Co(II), Ni(II) and Cu(II) with Schiff base ligand, 2-propyl-thioquinazolin 4(3H) semicarbazone.…”

Section: Oriental Journal Of Chemistrymentioning

confidence: 99%

Synthesis and Characterization of Cu(II), Ni(II) and Co(II) Coordination Compounds with Nitrogen and Oxygen Containing Schiff Base

Rai¹,

Kumar²,

Kumar³

et al. 2014

Orient. J. Chem

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Octahedral complexes has been designed and synthesized by a 2-propyl-thioquinozoline 4(3H) semicarbazone (PTQS) with Co(II), Ni(II) and Cu(II) metal ions. The complexes was characterized by molar mass, elemental analyses, IR electronic spectra, Molar conductivity and magnetic susceptibility assistance. On the above studies it was confirming that metal ions was coordinated with Carbonyl oxygen and azomethine nitrogen atom of semicarbazone moiety. The remaining valency of metal ions are satisfied by negative ions such as Cl -, Br -

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“…The biological activity of thiourea complexes has been successfully screened for various biological actions. On the other hand some thiourea derivatives have been used in commercial fungicides [3]- [6]. Substituted thioureas have recently gained much interest in the synthesis of wide variety of biologically active compounds [7] [8].…”

Section: Introductionmentioning

confidence: 99%