Cardiac changes in anorexia nervosa

Spaulding-Barclay, Michael A.; Stern, Judith M.; Mehler, Philip S.

doi:10.1017/s104795111500267x

Cited by 72 publications

(65 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Different degrees of positive correlations between diastolic function and anthropometric measurements (WAZ, HAZ, WHZ, MUAC) after rehabilitation were detected. Recently, Spaulding et al, 2016 reported that children with severe malnutrition suffer cardiac muscle wasting and ventricular dysfunction that responds well to nutritional rehabilitation therapy, also Nagla et al, 2010 concluded that nutritional rehabilitation reverses cardiac abnormalities significantly [3,24].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with severe PEM have multiple nutritional deficiencies, anaemia and frequent intercurrent illnesses. Moreover, PEM involves tissue protein all over the body causing severe wasting of skeletal muscles including but less severely the heart muscles [2,3]. These may variably influence the cardiac function [4] and may result in an inherent ventricular dysfunction [3].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, PEM involves tissue protein all over the body causing severe wasting of skeletal muscles including but less severely the heart muscles [2,3]. These may variably influence the cardiac function [4] and may result in an inherent ventricular dysfunction [3]. Myocardial disorders, whether cardiac arrhythmia or heart failure, are responsible for some deaths among kwashiorkor patients [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of left ventricular systolic and diastolic functions in severely malnourished children

Bebars

Askalany

2019

Egypt Pediatric Association Gaz

View full text Add to dashboard Cite

Background: Malnourished children endure many changes in body composition and lose heart and skeletal muscle mass. Diastolic dysfunction is one of the major causes of heart failure with preserved ejection fraction. Aim: To assess left ventricular systolic and diastolic functions in children with severe acute malnutrition using tissue Doppler imaging technique and to evaluate the effect of nutritional rehabilitation. Patients and Methods: A follow-up case-control study conducted on 60 severely malnourished children (WHZ <-3SD) and 120 age and sex-matched healthy children as a control group. Tissue Doppler imaging (TDI) was done for all included malnourished children at admission and for control to measure left ventricular systolic and diastolic functions. Nutritional rehabilitation was done according to WHO protocol and tissue doppler was repeated after rehabilitation when (WHZ >-2SD) to detect any changes in systolic or diastolic functions. Results: Systolic function was normal in malnourished children and control. Grade I diastolic dysfunction was detected in 40% and grade II in 30% of severely malnourished children in comparison to 100% normal diastolic function in control group. No correlations between diastolic dysfunction and either anthropometric measurements, electrolyte disturbances or Hb% in malnourished children before nutritional rehabilitation. Mortality from sepsis with associated ventricular dysfunction grade II documented in 3.3% of malnourished children. After nutritional rehabilitation diastolic function improved significantly as 65.6% of children attained normal diastolic function, 31% grade1 and 3.4% grade II. Positive correlations between diastolic function and WAZ, HAZ, WHZ and MUAC after rehabilitation. Conclusion: Severe acute malnutrition affects diastolic function in children which is reversible in most of these cases with rehabilitation. TDI is an easy and practical method for detection and follow-up of ventricular function in malnourished children.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of left ventricular systolic and diastolic functions in severely malnourished children

Bebars

Askalany

2019

Egypt Pediatric Association Gaz

View full text Add to dashboard Cite

show abstract

“…AN is an eating disorder that individuals experience to different extents, from being on a diet and deliberately inducing weight loss to deliberately and dramatically reducing body weight to far below healthy levels (79). The primary symptoms of AN are an excessive attention to weight and body image, intense fear of gaining weight, obsessive pursuit of thinness and significant reduction in weight.…”

Section: Targets Of Alzheimer's Disease (Ad)mentioning

confidence: 99%

Advanced research on deep brain stimulation in treating mental disorders (Review)

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Moreover, patients suffering from AN are characterised by neuroendocrine, immune, and autonomic nervous system (ANS) dysregulation resulting in cardiovascular complications and potentially leading to increased morbidity and mortality [ 3 , 4 , 5 ]. Cardiovascular complications occur in up to 80% of patients with AN, and account for up to 30% of mortality [ 6 ]. For example, sinus bradycardia (i.e., resting heart rate less than 50 beats per minute), relatively low arterial blood pressure (hypotension usually lower than 100/50 mmHg), prolonged QT interval, atherosclerosis, etc.…”

Section: Introductionmentioning

confidence: 99%

Role of Neuroendocrine, Immune, and Autonomic Nervous System in Anorexia Nervosa-Linked Cardiovascular Diseases

Sekaninova

Olexova

Višňovcová

et al. 2020

IJMS

View full text Add to dashboard Cite

Anorexia nervosa represents a severe mental disorder associated with food avoidance and malnutrition. In patients suffering from anorexia nervosa, cardiovascular complications are the main reason leading to morbidity and mortality. However, the origin and pathological mechanisms leading to higher cardiovascular risk in anorexia nervosa are still unclear. In this aspect, the issue of exact pathological mechanisms as well as sensitive biomarkers for detection of anorexia nervosa-linked cardiovascular risk are discussed. Therefore, this review synthesised recent evidence of dysfunction in multiple neuroendocrine axes and alterations in the immune system that may represent anorexia nervosa-linked pathological mechanisms contributing to complex cardiovascular dysregulation. Further, this review is focused on identification of non-invasive biomarkers for the assessment of increased cardiovascular risk in anorexia nervosa that can be linked to a clinical application. Complex non-invasive assessment of cardiovascular autonomic regulation—cardiac vagal control (heart rate variability), sympathetic vascular activity (blood pressure variability), and cardiovascular reflex control (baroreflex sensitivity)—could represent a promising tool for early diagnosis, personalized therapy, and monitoring of therapeutic interventions in anorexia nervosa particularly at a vulnerable adolescent age.

show abstract

Cardiac changes in anorexia nervosa

Abstract: Cardiac changes are inherent to anorexia nervosa and they become more life-threatening and serious as the anorexia nervosa becomes increasingly severe. Weight restoration and attention to these cardiac changes are crucial for a successful treatment outcome.

Cited by 72 publications

References 84 publications

Assessment of left ventricular systolic and diastolic functions in severely malnourished children

Assessment of left ventricular systolic and diastolic functions in severely malnourished children

Advanced research on deep brain stimulation in treating mental disorders (Review)

Role of Neuroendocrine, Immune, and Autonomic Nervous System in Anorexia Nervosa-Linked Cardiovascular Diseases

Contact Info

Product

Resources

About