Cardiac Computed Tomography as an Alternative Technique in the Assessment of Acute Myocardial Ischemia in the Context of COVID-19 Infection

Azanza, Diego Xavier Chango; Ibargüengoitia, Mónica Chapa; Uvera, Sandra Rosales

doi:10.7759/cureus.11415

Cited by 3 publications

(1 citation statement)

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“…The autopsy pathology of patients with COVID-19 found microscopic evidence that suggested acute ischemic injury [ 15 ]. Impaired cardiac systolic function was detected in patients with COVID-19 and ICM by cardiac computed tomography [ 16 ]. However, the common pathogenesis of ICM and COVID-19 remains to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology

Luo

Zhang

et al. 2023

IJMS

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Cardiovascular complications combined with COVID-19 (SARS-CoV-2) lead to a poor prognosis in patients. The common pathogenesis of ischemic cardiomyopathy (ICM) and COVID-19 is still unclear. Here, we explored potential molecular mechanisms and biomarkers for ICM and COVID-19. Common differentially expressed genes (DEGs) of ICM (GSE5406) and COVID-19 (GSE164805) were identified using GEO2R. We performed enrichment and protein–protein interaction analyses and screened key genes. To confirm the diagnostic performance for these hub genes, we used external datasets (GSE116250 and GSE211979) and plotted ROC curves. Transcription factor and microRNA regulatory networks were constructed for the validated hub genes. Finally, drug prediction and molecular docking validation were performed using cMAP. We identified 81 common DEGs, many of which were enriched in terms of their relation to angiogenesis. Three DEGs were identified as key hub genes (HSP90AA1, HSPA9, and SRSF1) in the protein–protein interaction analysis. These hub genes had high diagnostic performance in the four datasets (AUC > 0.7). Mir-16-5p and KLF9 transcription factor co-regulated these hub genes. The drugs vindesine and ON-01910 showed good binding performance to the hub genes. We identified HSP90AA1, HSPA9, and SRSF1 as markers for the co-pathogenesis of ICM and COVID-19, and showed that co-pathogenesis of ICM and COVID-19 may be related to angiogenesis. Vindesine and ON-01910 were predicted as potential therapeutic agents. Our findings will contribute to a deeper understanding of the comorbidity of ICM with COVID-19.

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Section: Introductionmentioning

confidence: 99%