Cardiac Drug Therapy

Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse

“…Previous studies have shown that ARBs perform better than ACEi in respiratory disorders such as ARDS induced by bacterial infection, as angiotensin II can be synthesized by some alternative enzymes such as chymase, cathepsin and trypsin [9,10]. Thus in our study, we focused on losartan, the first orally active non-peptide selective ARB, to further investigate its therapeutic role in ALI induced by H5N1 virus.…”

Nutraceuticals in Cardiovascular Diseases

“…Conventional approaches to heart disease are reported in detail by Khan (2015) and Fuster (2004). Angiotensinconverting enzyme (ACE) inhibitors prevent conversion of angiotensin I to angiotensin II and help arteriolar and venous dilation, decrease in sympathetic activity, and release of norepinephrine.…”

“…Calcium channel blockers are antihypertensive agents that take precedence over beta-blockers, ACE inhibitors, and diuretics (Khan, 2015). By antagonizing extracellular calcium entry and the subsequent calcium release from the sarcoplasmic reticulum, they lower BP and reduce heart rate.…”