Cardiac Dysfunction in Active Pulmonary Tuberculosis: Double Trouble!!

Patil, Shital; Narwade, Ganesh; Gondhali, Gajanan

doi:10.1183/13993003.congress-2020.1604

Cited by 9 publications

(12 citation statements)

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“…In one of the studies with endomyocardial biopsy, biventricular involvement was noted in approximately 70% of patients and alone RV myocarditis in 8% [11]. Echocardiography is sensitive tool to diagnose myocardial involvement and abnormalities documented as regional or global wall motion abnormality, dilated chambers and systolic or diastolic ventricular dysfunction and reduced ejection fraction [12]. Echocardiography is not specific for myocarditis unless myocardial echogenicity is present.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary tuberculosis with cardiac dysfunction: An ignored combination!

et al. 2023

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Cardiovascular involvement is rare in tuberculosis & high index of suspicion is must in diagnosing these cases in high burden setting to have successful treatment outcome. In this case report, 26-year male, presented with constitutional symptoms for three months duration with acute deterioration with tachycardia and tachypnea with hypoxia. Radiological investigations documented conglomerated miliary tuberculosis and confirmed by sputum smear microscopy. Cardiac investigations revealed sinus tachycardia in ECG, raised cardiac enzymes, and echocardiography as ‘global left ventricular hypokinesia’ with reduced ejection fraction. Treatment initiated with steroids with anti-tuberculosis and recorded near complete radiological resolution, bacteriological cure and restored cardiac function after six months with good compliance. We recommend cardiac workup in all pulmonary tuberculosis cases with disproportionate tachycardia.

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Section: Discussionmentioning

confidence: 99%

Pulmonary tuberculosis with cardiac dysfunction: An ignored combination!

et al. 2023

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“…is coinfection was described in both genders and in all age groups including a three-month-old Gambian patient, with a slight predominance in males and migrants [4]. ese cases were only reported in some countries like Italy [5][6][7][8][9], Singapore [10,11], India [12][13][14][15], China [16][17][18][19], Brazil [20,21], Turkey [22,23], Saudi Arabia [24][25][26], and Mexico [27].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Pulmonary Tuberculosis Coinfection in a Moroccan Patient with Pulmonary Embolism: A Case Report and Literature Review

Zouaki

Chahbi

Raiteb

et al. 2022

Case Reports in Infectious Diseases

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Emerging cases of coinfection of coronavirus disease 2019 (COVID-19) and tuberculosis (TB), although rare, have attracted the attention of health systems around the world and have arisen many concerns about the diagnosis, treatment, and prognosis of this coinfection especially in high TB burden countries. Here, we report a rare case and, to the best of our knowledge, the first reported case in Morocco of simultaneous diagnosis of an active pulmonary TB infection and a COVID-19 pneumonia. We present a case of a sixty-seven-year-old male patient who was admitted to our COVID-19 emergency department with a diagnosis of COVID-19 pneumonia, confirmed by nasopharyngeal swab’s polymerase chain reaction (PCR) for detection of SARS-CoV-2. The atypical radiological findings suggested a TB coinfection which was later confirmed by sputum cultures and Xpert MTB/Rif assay. The patient also presented some complications including thrombosis of the left leg, pulmonary embolism and inaugural ketosis. Treatment was administered as per local protocols: broad spectrum antibiotics, corticosteroids, fixed dose-combination of antituberculosis treatment along with hydration and insulin therapy for ketosis treatment and anticoagulation. The patient was discharged after twenty-three days of hospitalization. Due to the currently limited data, further studies are necessary to establish any possible correlation between COVID-19 infection and the progression of a latent and/or the severity of an active TB infection.

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“…Pulmonary tuberculosis can have diverse Ca s e R epo rt presentations ranging from cavitation, consolidation, tumorous lesions, lower lung filed tuberculosis and endobronchial and miliary nodules [2][3][4][5][6][7][8][9][10][11][12]. Similarly, non-tuberculous pathologies can present with abnormalities such as consolidations, nodules, cavitations mimicking tuberculosis [2][3][4][5][6][7][8][9][10][11][12][13][14]. Bronchoscopy is a very crucial interventional pulmonology technique in evaluating these cases [2][3][4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, non-tuberculous pathologies can present with abnormalities such as consolidations, nodules, cavitations mimicking tuberculosis [2][3][4][5][6][7][8][9][10][11][12][13][14]. Bronchoscopy is a very crucial interventional pulmonology technique in evaluating these cases [2][3][4][5][6][7][8][9][10][11][12][13][14]. High risk factors for tuberculosis would be advanced age, malnutrition, pregnancy, steroids exposure, diabetes mellitus and immunosuppression [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Bronchoscopy is a very crucial interventional pulmonology technique in evaluating these cases [2][3][4][5][6][7][8][9][10][11][12][13][14]. High risk factors for tuberculosis would be advanced age, malnutrition, pregnancy, steroids exposure, diabetes mellitus and immunosuppression [9][10][11][12][13][14]. Tuberculosis in advanced stage may cause cardiac dysfunction and systemic effects which will have poor outcome if timely treatment not received [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Progressive Primary Pulmonary Tuberculosis in Current Times: Are we really heading Towards ‘End of TB’ or Still, Many Miles to go for ‘Dream Come True’?

Patil¹,

Gondhali²,

Choudhari³

et al. 2023

SAR J Med

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Tuberculosis is a more prevalent disease and the leading cause of death from an infectious agent in India. Tuberculosis in India accounts for the highest number of cases and deaths annually in the world. In spite of an efficient National tuberculosis control program for five decades, Tuberculosis is still the number one cause of death due to infectious agents in India and one third of total global deaths occurs in India due to this disease. Burden of drug sensitive and drug resistant cases is highest in the south east Asian region with maximum cases in India and China. India has launched a National strategic plan to end TB in 2017 with a target to eliminate TB by 2025. Main theme of the national strategic plan is ‘TB Free India’ with the vision of zero TB disease, zero deaths due to TB and decreasing poverty due to TB. Tuberculosis is an ancient disease and history traced before the evolution of mankind on this planet. Tuberculosis primarily affects the lung and is classified pathologically as primary, post-primary and progressive primary tuberculosis. In this case report, a 62-year male, presented with constitutional symptoms for six-month duration with partial response to medical treatment. He was having low grade fever, cough, shortness of breath, weight loss and anorexia for 6 months. His symptoms were progressive and empirically treated as enteric or typhoid fever for four to five occasions with oral and intravenous antibiotics with steroids with general physicians and family physicians. Additionally, he received empirical treatment as jaundice, viral fever, bronchitis, asthma, and generalised debilitating disease. Relatives brought to our center worsened general health with increased shortness of breath. Clinically he was having bilateral crepitations with decreased breath sounds right lower axillary and infrascapular area. Chest x-ray showed right pleural effusion with miliary opacities bilateral lung field. HRCT thorax showed typical miliary opacities with conglomerated pattern and pleural effusion on the right side of thorax. Pleural fluid analysis revealed exudative effusion with raised ADA level. He was unable to produce sputum, we have done bronchoscopy and BAL evaluation confirmed pulmonary tuberculosis and sensitivity pattern. BAL cytology documented acid-fast bacilli in smear and MTB genome with rifampicin sensitivity in cartridge based nucleic acid amplification test. Treatment initiated with anti-tuberculosis (ATT). We have recorded near complete radiological resolution, bacteriological cure after eight months of ATT with good compliance. More awareness is required regarding symptoms, diagnosis and treatment of tuberculosis to family physicians and general practitioners as the majority of the rural population receives treatment from these health professionals.

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Cardiac Dysfunction in Active Pulmonary Tuberculosis: Double Trouble!!

Cited by 9 publications

References 0 publications

Pulmonary tuberculosis with cardiac dysfunction: An ignored combination!

Pulmonary tuberculosis with cardiac dysfunction: An ignored combination!

COVID-19 and Pulmonary Tuberculosis Coinfection in a Moroccan Patient with Pulmonary Embolism: A Case Report and Literature Review

Progressive Primary Pulmonary Tuberculosis in Current Times: Are we really heading Towards ‘End of TB’ or Still, Many Miles to go for ‘Dream Come True’?

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