Cardiac effects of l-thyroxine administration in borderline hypothyroidism

Mariotti, Stefano; Zoncu, Sandra; Pigliaru, Francesco; Putzu, Claudia; Cambuli, Valentina M.; Vargiu, Sara; Deidda, Martino; Mercuro, Giuseppe

doi:10.1016/j.ijcard.2007.03.130

Cited by 16 publications

(15 citation statements)

References 24 publications

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“…We used TDI-derived parameters such as S, IVV, and IVA to evaluate LV systolic functions. Similar to our study, Mariotti et al [22] found impaired LV systolic functions using S and observed a significant improvement following l-T 4 substitution therapy. The main finding in our study was the ability of IVA, which is a reliable systolic parameter that is not influenced by preload and afterload changes, to show impairment in LV systolic functions.…”

Section: Resultssupporting

confidence: 92%

Evaluation of ventricular functions using tissue Doppler echocardiography in patients with subclinical hypothyroidism

Öner¹,

Yurdakul²,

Oner³

et al. 2011

Turk Kardiyol Dern Ars

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Section: Resultssupporting

confidence: 92%

Evaluation of ventricular functions using tissue Doppler echocardiography in patients with subclinical hypothyroidism

Öner¹,

Yurdakul²,

Oner³

et al. 2011

Turk Kardiyol Dern Ars

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“…TSI parameters of asynchrony (including Ts‐SD‐12, Ts‐12, Ts‐SD‐6, and Ts‐6) were clearly prolonged in patients with overt hypothyroidism compared with the control group. In addition, Sm and Em velocities of four‐basal segments of LV were lower in hypothyroid group than control group as compatible with previous studies 31‐33 …”

Section: Discussionsupporting

confidence: 92%

Assessment of Left Ventricular Systolic Asynchrony in Patients with Clinical Hypothyroidism

et al. 2010

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“…The impact of altered myocardial metabolism on the cardiac function is evidenced, for instance, in echocardiographic studies of patients with diabetes mellitus, thyroid disorders, and thiamine deficiency. [1][2][3][4] Several metabolic disturbances including obesity, 5 mitochondrial genetic disorders, 6 and lipid abnormalities 7 are also closely linked to the HF risk, but even subtle metabolic variations (e.g. high-normal blood glucose levels) may antedate overt HF by years, underscoring the potential relevance of metabolomics for long-term HF risk prediction.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic signatures of cardiac remodelling and heart failure risk in the community

et al. 2020

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Aims Heart failure (HF) is associated with several metabolic changes, but it is unknown whether distinct components of the circulating metabolome may be related to cardiac structure and function, and with incident HF in the community. Methods and results We assayed 217 circulating metabolites in 2336 Framingham Study participants (mean age 55 ± 10 years, 53% women) without HF at baseline. We used linear and Cox regression to relate concentrations of metabolites to left ventricular (LV) diastolic dimension, LV wall thickness, LV ejection fraction, left atrial dimension, LV ventricular mass, and aortic root size cross-sectionally and to incident HF prospectively. Bonferroni-adjusted P-values <0.05 denoted statistical significance. Circulating concentrations of kynurenine [β = À0.12 cm per standard deviation (SD) increment in normalized residual of metabolite, P = 7.3 × 10 À8 ] and aminoadipate (À0.11 cm per SD increment, P = 2.61 × 10 À5) were associated with left ventricular diastolic dimension, phosphatidylcholine (carbon:double bound = 38:6) with left atrial dimension (0.10 cm per SD increment, P = 9.7 × 10 À6), and cholesterol ester (carbon:double bound = 20:5) with left atrial dimension (0.10 cm per SD increment, P = 1.4 × 10 À5) in multivariable-adjusted models. During an average follow-up of 15.8 (range 0.02-23.2) years, 113 participants (5%) were diagnosed with HF with reduced ejection fraction and 106 individuals (5%) with HF with preserved ejection fraction. In multivariable analyses, concentrations of phosphatidylcholine (hazard ratio 0.63, P = 1.3 × 10 À5) and ornithine (hazard ratio 1.44, P = 0.00014) were associated with HF with reduced ejection fraction. Conclusions Several metabolites, including the vasoactive metabolite kynurenine, were related to cardiac structure and function in our sample. Additional research is warranted to confirm our observations and investigate if these metabolites can risk stratify ambulatory individuals.

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Cardiac effects of l-thyroxine administration in borderline hypothyroidism

Cited by 16 publications

References 24 publications

Evaluation of ventricular functions using tissue Doppler echocardiography in patients with subclinical hypothyroidism

Evaluation of ventricular functions using tissue Doppler echocardiography in patients with subclinical hypothyroidism

Assessment of Left Ventricular Systolic Asynchrony in Patients with Clinical Hypothyroidism

Metabolomic signatures of cardiac remodelling and heart failure risk in the community

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