Cardiac Function in Adult Patients with Juvenile Idiopathic Arthritis

Aulie, Hanne Aaserud; Estensen, Mette E; Selvaag, Anne M; Lilleby, Vibke; Murbræch, Klaus; Flatø, Berit; Aakhus, Svend

doi:10.3899/jrheum.141351

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…Peak trans-mitral E velocity and E/A velocity ratio was significantly lower among JIA patients compared to the healthy group which supports diastolic dysfunction. Our data are consistent with the data of many studies [14, 28, 29, 33]. …”

Section: Discussionsupporting

confidence: 93%

Assessment of left atrial mechanical functions and atrial electromechanical delay in Juvenile idiopathic arthritis by tissue Doppler echocardiography

et al. 2016

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BackgroundJuvenile idiopathic arthritis (JIA) is a systemic chronic inflammatory disease. Studies using tissue Doppler imaging (TDI) for the evaluation of cardiac functions of children with JIA are limited. Thus, this study was conducted to evaluate Left ventricular function, left atrial mechanical functions and atrial electromechanical delay in JIA.MethodsThis study was carried out as a across sectional study. A total of 34 patients with active JIA and 34 controls were included. Atrial electromechanical delay and left atrial (LA) mechanical functions in addition to systolic and diastolic left ventricular (LV) functions were measured by using conventional echocardiography and TDI. Assessment of disease activity was done using Juvenile arthritis disease activity score (JADAS-27).ResultsJIA patients had abnormal atrial electromechanical coupling as established from prolonged lateral mitral annulus (PA lateral), septal mitral annulus (PA septum), inter-atrial and intra-atrial electromechanical delays compared with healthy controls. Left ventricular filling abnormalities were found characterized by a reduced E/A ratio (1.07 ± 0.56 vs. 1.48 ± 0.16, p = 0.01). E/Em was significantly higher in patients with JIA (7.58 ± 1.79 vs. 4.74 ± 1.45, p = 0.003) denoting impaired diastolic function. Left atrial mechanical functions assessment showed significantly decreased LA passive emptying fraction, increased LA active emptying fraction and LA total emptying volume in JIA patients (p = 0.01, p = 0.01, p = 0.03 respectively).ConclusionAtrial electromechanical coupling intervals, and LA mechanical functions were impaired which can be considered as an early form of subclinical cardiac involvement in JIA patients. Significant diastolic functional abnormalities exist in JIA.

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Section: Discussionsupporting

confidence: 93%

Assessment of left atrial mechanical functions and atrial electromechanical delay in Juvenile idiopathic arthritis by tissue Doppler echocardiography

et al. 2016

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“…Ninety controls matched for age and sex were selected from the general population at 30‐year followup . Demographic characteristics of the 176 patients and 90 controls and clinical characteristics for the 176 patients at 30‐year followup are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Disease onset was defined as the day a physician documented symptoms or signs of JIA. At the 30‐year followup, patients were compared to 90 controls matched for age and sex, recruited randomly from the National Registry in Oslo and the surrounding county of Akershus . The Regional Committees for Medical and Health Research Ethics approved the study, and informed consent was obtained in accordance with the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%