Cardiac glycoside neriifolin exerts anti-cancer activity in prostate cancer cells by attenuating DNA damage repair through endoplasmic reticulum stress

Zhao, Wanlu; Li, Guihuan; Zhang, Qianbing; Chen, Meixuan; Wu, Zhicong; Zhang, Yihe; Fan, Mingming; Liang, Yantao; Zhang, Wenlong; Zeng, Fanning; Deng, Fan

doi:10.1016/j.bcp.2023.115453

Cited by 5 publications

(1 citation statement)

References 56 publications

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“…Neriifolin , a cardiac glycoside, has demonstrated its potential in suppressing malignant characteristics of prostate cancer cells. It achieves this by activating endoplasmic reticulum stress (ERS), which impacts the induction of antitumor inhibitory receptors, thereby enhancing DNA damage and apoptosis ( 131 ). Digoxin , a classic cardiac glycoside, exhibits potential in reducing inflammation and fibrosis in a mouse model of pulmonary fibrosis.…”

Section: New Findings Of Tcm Natural Products and Derivatives As Immu...mentioning

confidence: 99%

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Miao,

Liu,

et al. 2023

Front. Immunol.

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At present, cancer is the largest culprit that endangers human health. The current treatment options for cancer mainly include surgical resection, adjuvant radiotherapy and chemotherapy, but their therapeutic effects and long-term prognosis are unsatisfactory. Immunotherapy is an emerging therapy that has completely transformed the therapeutic landscape of advanced cancers, and has tried to occupy a place in the neoadjuvant therapy of resectable tumors. However, not all patients respond to immunotherapy due to the immunological and molecular features of the tumors. Traditional Chinese Medicine (TCM) provides a new perspective for cancer treatment and is considered to have the potential as promising anti-tumor drugs considering its immunoregulatory properties. This review concludes commonly used TCM monomers and compounds from the perspective of immune regulatory pathways, aiming to clearly introduce the basic mechanisms of TCM in boosting cancer immunotherapy and mechanisms of several common TCM. In addition, we also summarized closed and ongoing trials and presented prospects for future development. Due to the significant role of immunotherapy in the treatment of non-small cell lung cancer (NSCLC), TCM combined with immunotherapy should be emphasized in NSCLC.

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Section: New Findings Of Tcm Natural Products and Derivatives As Immu...mentioning

confidence: 99%

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Miao,

Liu,

et al. 2023

Front. Immunol.

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Acovenosigenin A β-glucoside mediates JAK2-STAT3 signaling pathway by targeting GP130 in A549 and H460 cells based on integrative analysis of transcriptome and proteome and biological verification

Liu,

Wang,

Chi

et al. 2024

Bioorganic Chemistry

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Porcine IGFBP3 promotes porcine circovirus type 2 replication via PERK/eIF2α mediated DNA damage

Pan,

Huan,

Hou

et al. 2023

Veterinary Microbiology

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Cardiac glycoside neriifolin exerts anti-cancer activity in prostate cancer cells by attenuating DNA damage repair through endoplasmic reticulum stress

Cited by 5 publications

References 56 publications

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Acovenosigenin A β-glucoside mediates JAK2-STAT3 signaling pathway by targeting GP130 in A549 and H460 cells based on integrative analysis of transcriptome and proteome and biological verification

Porcine IGFBP3 promotes porcine circovirus type 2 replication via PERK/eIF2α mediated DNA damage

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