Cardiac metastasis from Merkel cell skin carcinoma

Yamana, Nobuko; Sueyama, Hiroo; Hamada, Masaaki

doi:10.1007/s10147-004-0396-2

Cited by 13 publications

(7 citation statements)

References 13 publications

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“…There were 14 unique patients with cardiac mMCC reported in the published case reports between 1990 to 2019 ( Table 4 ) [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. The median age at diagnosis was 67.5 years (range 23–82 years) with a male predominance (male 9, female 5).…”

Section: Resultsmentioning

confidence: 99%

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Management and Prognosis of Cardiac Metastatic Merkel Cell Carcinoma: A Case–Control Study and Literature Review

Akaike

Cahill

Akaike

et al. 2022

Cancers

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Merkel cell carcinoma (MCC), an aggressive neuroendocrine skin cancer, has a high rate (20%) of distant metastasis. Within a prospective registry of 582 patients with metastatic MCC (mMCC) diagnosed between 2003–2021, we identified 9 (1.5%) patients who developed cardiac metastatic MCC (mMCC). We compared overall survival (OS) between patients with cardiac and non-cardiac metastases in a matched case–control study. Cardiac metastasis was a late event (median 925 days from initial MCC diagnosis). The right heart was predominantly involved (8 of 9; 89%). Among 7 patients treated with immunotherapy, 6 achieved a complete or partial response of the cardiac lesion. Among these 6 responders, 5 received concurrent cardiac radiotherapy (median 20 Gray) with immunotherapy; 4 of 5 did not have local disease progression or recurrence in the treated cardiac lesion. One-year OS was 44%, which was not significantly different from non-cardiac mMCC patients (45%, p = 0.96). Though it occurs relatively late in the disease course, cardiac mMCC responded to immunotherapy and/or radiotherapy and was not associated with worse prognosis compared to mMCC at other anatomic sites. These results are timely as cardiac mMCC may be increasingly encountered in the era of immunotherapy as patients with metastatic MCC live longer.

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Section: Resultsmentioning

confidence: 99%

“…MCC metastasis to the heart is rare, with experience limited to isolated case reports [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Before the era of immunotherapy, the prognosis of metastatic MCC (mMCC) was limited to months [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Management and Prognosis of Cardiac Metastatic Merkel Cell Carcinoma: A Case–Control Study and Literature Review

Akaike

Cahill

Akaike

et al. 2022

Cancers

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“…Due to the high rates of local relapse, routine use of 45–60 Gy [ 8 , 10 ] to the area of the lesion has been found to decrease local recurrence [ 36 ]. Other series showed no significant difference compared with surgery only [ 11 ] and distant metastasis and overall survival seem to be similar compared to those who did not receive radiation [ 10 , 37 ]. Postoperative radiotherapy could be beneficial in cases of large primary tumours or unattainable free surgical margins due to cosmetic or functional difficulties [ 4 , 8 ] but radiating permanent margins did not yield satisfactory results [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 , 11 ] Regional metastases are common, and distant metastases can also occur, particularly in liver, bone, lung, brain and skin. Rare cases of distant metastases of MCC in bone marrow, pleura, testis, small bowel and stomach have been reported [ 5 , 8 , 37 ]. Treatment in case of MCC with distal metastases consists of palliative radiotherapy and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Merkel cell carcinoma of the upper extremity: Case report and an update

Papamichail

Nikolaidis

et al. 2008

World J Surg Onc

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“…18 FDG, 68 Ga somatostatin receptor or DOTANOC PET/CT enables detection of these rare sites of metastasis [3][4][5]. It should be noted that despite their low frequency, Merkel cell tumors (primary cutaneous neuroendocrine tumors) account for 12% of reported cases (4 published cases) [8]. The incidence of heart metastasis from neuroendocrine tumors is about 4% [6].…”

Section: Figurementioning

confidence: 99%