Cardiac output during ritodrine treatment in premature labor

Bieniarz, J; Ivankovich, Anthony D.; Scommegna, Antonio

doi:10.1016/0002-9378(74)90660-7

Cited by 63 publications

(14 citation statements)

References 14 publications

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“…In a recent study (8) we were able to show that isoxuprine, the first beta-adrenergic agent brought into obstetric tocolytic therapy, increases the placental blood flow in normal late pregnancy, but does not have the same positive effect in hypertensive pregnancy. Bieniarz et al (1) showed that intravenous infusion of ritodrine increases maternal cardiac output. Proceeding from this basis, it would seem possible that the placental blood flow is also altered positively.…”

Section: Introductionmentioning

confidence: 99%

Ritodrine Hydrochloride Induced Cardiopulmonary and Placental Hemodynamic Changes in Normal and Hypertensive Late Pregnancy

Suonio¹,

Olkkonen²,

Castrén³

1976

International Journal of Gynecology & Obstetrics

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Cardiopulmonary parameters (minute volume, heart rate, stroke volume, right heart, pulmonary and left heart blood volumes), blood pressure and placental blood flow were evaluated in 20 normal patients, nine patients with preeclamptic disease and 12 with essential hypertension in late pregnancy before and 60 minutes after a single i.m. dose of 10 mg of ritodrine hydrochloride. The drug caused a statistically significant increase in heart rate in all the patient groups, while the systolic and diastolic blood pressures were only slightly affected. Minute volume was unchanged in the group of normal patients, but in both hypertensive groups there was a significant increase. The placental perfusion index was statistically nearly significantly decreased in the group of uncomplicated pregnancies, statistically significantly increased in preeclamptic patients, and not affected in the group with essential hypertension. Ritodrine hydrochloride medication can be expected to have a positive effect on placental blood flow only in preeclamptic disease, and then probably in the milder forms of the disease.

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Section: Introductionmentioning

confidence: 99%

Ritodrine Hydrochloride Induced Cardiopulmonary and Placental Hemodynamic Changes in Normal and Hypertensive Late Pregnancy

Suonio¹,

Olkkonen²,

Castrén³

1976

International Journal of Gynecology & Obstetrics

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“…The pharmacological effects of ritodrine on the cardiovascular system are moderate tachycardia, a slightly elevated systolic blood pressure, a slightly depressed diastolic blood pressure, decreased peripheral resistance, and increased cardiac output, but these effects are of little significance in normally pregnant women (1, 7, 9). These effects on the heart can be blocked by a beta-blocking agent, but this will diminish the effect on labor in proportion to the amount given (3).…”

Section: Discussionmentioning

confidence: 99%

Direct Current Conversion of Maternal Supraventricular Tachycardia Developed During the Treatment of a Pregnant Heroin Addict With Ritodrine

Fink

Weber

1981

Acta Obstet Gynecol Scand

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During ritodrine (UtoparR) treatment for premature labor, a chronic heroin-addicted patient developed supraventricular tachycardia which was treated by direct current (d.c) conversion, d.c. conversion did not affect the fetus, as judged by the cardiotocogram. As heroin addicts run an increased risk or developing cardiac arrhythmia, caution is advised when treating these patients with beta-mimetics.

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“…Cardiac side-effects include increase in heart rate and systolic blood pressure, myocardial ischemia, as well as pulmonary oedema. Cardiac output has been shown to increase by 60% with terbutaline and ritodrine [28,29]. In some rare cases, β2 adrenergic agonists have been associated with maternal death from cardiac etiologies [30].…”

Section: 41maternal Side Effectsmentioning

confidence: 99%

Preterm Labour: An Overview of Current and Emerging Therapeutics

Schwarz¹,

Page²

2003

CMC

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Preterm labour is a major cause of perinatal mortality and morbidity. However, during the past 40 years of clinical studies and despite the use of multiple therapeutic agents, the rate of preterm birth has not drastically declined. In 1991, it was estimated that in the US approximately 116,000 women admitted with acute episodes of preterm labour were treated each year with ritodrine, which is the first drug approved by the US FDA and still remains the standard therapy for treating preterm labour. Ritodrine (Yutopar( trade mark )) stimulates the beta(2)-adrenergic receptor throughout the body, causing an inhibitory action in different tissues that, among other side effects, also leads to an attenuation of uterine contractility. More recently, a new therapeutic agent, atosiban (Tractocile( trade mark )), a peptidic oxytocin receptor antagonist, has been introduced to the market. However, the use of the various pharmacological agents to treat preterm labour remains restricted, due to lack of uterine selectivity, low efficacy and potentially serious side effects for the mother or the foetus. Therefore, there is an urgent need to develop drugs with myometrial selectivity that would allow long-lasting inhibition of labour and prolong pregnancy up to a stage when good foetal maturation raises the chances of survival. One of the major obstacles hampering the development of new therapeutic agents is the marked inter-species difference in terms of preterm labour physiology, which complicates the preclinical evaluation of new candidate molecules in animal models of disease. In this review, the authors will provide a comprehensive update of past, current and new approaches for the management of preterm labour, including beta(2)-adrenergic agonists, calcium channel blockers, oxytocin antagonists, prostaglandin antagonists and other potential therapeutics. For each of the therapies used today, the review will cover the mechanism of action, benefit and adverse effects, and discuss the promise and potential benefits of new emerging therapeutic agents.

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Cardiac output during ritodrine treatment in premature labor

Cited by 63 publications

References 14 publications

Ritodrine Hydrochloride Induced Cardiopulmonary and Placental Hemodynamic Changes in Normal and Hypertensive Late Pregnancy

Ritodrine Hydrochloride Induced Cardiopulmonary and Placental Hemodynamic Changes in Normal and Hypertensive Late Pregnancy

Direct Current Conversion of Maternal Supraventricular Tachycardia Developed During the Treatment of a Pregnant Heroin Addict With Ritodrine

Preterm Labour: An Overview of Current and Emerging Therapeutics

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