Cardiac resynchronization therapy in left ventricular hypertrabeculation/non-compaction and myopathy

Abstract

CRT by biventricular pacing in LVHT, heart failure, and myopathy leads to improvement in functional capacity in all patients and improvement of systolic function in half of the patients. The weak response of LVHT patients to CRT may be due to inappropriate selection or comorbidities, in particular, neuromuscular disorders.

Cardiac and neuromuscular implications of left bundle branch block in left ventricular hypertrabeculation/noncompaction

“…It is also in contrast to epidemiological studies that found a worse prognosis when LBB was associated with dilated cardiomyopathy and myocarditis (22). This may be explained by the fact that LVHT patients with LBB responded well to cardiac therapy and, at least in some cases, to the cardiac resynchronization device (23). Furthermore, LBB was not associated with NMDs, which have been identified as indicators of a higher mortality rate.…”

Neuromuscular and cardiac comorbidity determines survival in 140 patients with left ventricular hypertrabeculation/noncompaction

“…One hundred sixteen of the 140 cases, diagnosed until October 2007, have been published previously [11][12][13][14]. The demographic and clinical baseline data of the included patients are listed in Table 1.…”

Left ventricular non-compaction and its cardiac and neurologic implications

“…CRT was even beneficial in a young child [88]. In a study on 102 LVHT patients, 8 had received a CRT system and all but one variably improved with regard to NYHA class, end-diastolic diameter, or systolic function [115]. If congestive heart failure does not even respond to CRT, heart transplantation (HTX) should be considered, which has been successfully carried out in a number of LVHT patients [19,116,117].…”