Cardiac Sympathetic Denervation Assessed With 123-Iodine Metaiodobenzylguanidine Imaging Predicts Ventricular Arrhythmias in Implantable Cardioverter-Defibrillator Patients

Boogers, Mark J.; Borleffs, C. Jan Willem; Henneman, Maureen M.; Bommel, Rutger J. van; Ramshorst, Jan van; Boersma, Eric; Dibbets‐Schneider, Petra; Stokkel, Marcel P. M.; Wall, Ernst E. van der; Schalij, Martin J.; Bax, Jeroen J.

doi:10.1016/j.jacc.2009.12.066

Cited by 330 publications

(255 citation statements)

References 25 publications

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“…126 Interestingly neither of these latter two studies found a correlation of autonomic/perfusion mismatch with pre-disposition to arrhythmias. Thus, there are consistent findings that 123 I-mIBG images can predict ICD discharges and SCD independent of conventional variables.…”

Section: Cardiac Arrhythmiasmentioning

confidence: 96%

Cardiac autonomic imaging with SPECT tracers

Travin

2013

Journal of Nuclear Cardiology

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Section: Cardiac Arrhythmiasmentioning

confidence: 96%

Cardiac autonomic imaging with SPECT tracers

Travin

2013

Journal of Nuclear Cardiology

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“…Increased sympathetic nervous activity or denervation are seen in heart failure patients, and could be imaged with myocardial 123 I-MIBG image (16). Several reports have shown the clinical usefulness of 123 I-MIBG for prediction of major cardiac events, including heart failure hospitalization or cardiac death (17)(18)(19)(20), discharge of implantable cardioverter defibrillator (21), or evaluation of the effectiveness of betablockade (22)(23)(24)(25)(26), renin-angiotensin-aldosterone system inhibitor (27)(28)(29), and nicorandil (30,31) in patients with heart failure. And, a multi-center study of ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) trial was conducted (32), and meta-analysis of Japanese-single cohort was also performed (33) and verified the perceptions of the previous studies.…”

Section: Sympathetic Nerve Functional Imaging With 123 I-mibgmentioning

confidence: 99%

Nuclear Molecular Imaging of the Failing Heart

Ohshima

Isobe

Murohara

2018

Annals of Nuclear Cardiology

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Nuclear imaging of the failing myocardium is targeting the impaired part related to several processes of myocardial metabolism or work. Myocardium mainly utilizes fatty acid or glucose for ATP production in mitochondria. Intracellular calcium handling, which needs an amount of ATPs, induces myocardial contraction and relaxation, and is regulated with beta adrenal-stimulation. In the failing myocardium, any of these parts related to the myocardial work are variedly impaired, and could be the imaging target. Despite recent advancement of heart failure treatment, the patients with heart failure remain in high morbidity and mortality.For appropriate managements or prediction of prognosis in patients with heart failure, it is important to evaluate the mechanism of the failing myocardium. In this article, we focus on the usefulness of the 2 radionuclide imaging in evaluating sympathetic nerve function using myocardial 123 I-MIBG scintigraphy and mitochondrial function using myocardial 99m Tc-sestamibi SPECT in the patients with cardiomyopathy.

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“…78 The extent or severity of autonomic defects predicted VT inducibility 79 and occurrence of an ICD discharge or SCD. 80 PET tracers such as 11C-hydroxyephedrine (11-CHED) improve the signal-noise ratio allowing better quantification. 81 The recent Prediction of Arrhythmic Events with Positron Emission Tomography (PAREPET) study 82 has proved that the extent of uptake defects correlated with the occurrence of SCD or ICD discharge.…”

Section: Sympathetic Activitymentioning

confidence: 99%

Novel Imaging Techniques for Heart Failure

Melero-Ferrer

López‐Vilella

Morillas-Climent

et al. 2016

Cardiac Failure Review

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Heart failure (HF) is an epidemic with an increasing prevalence and an absolute mortality rate of approximately 50 % within 5 years of diagnosis. Imaging plays a main role in HF diagnosis, assessment of aetiology and treatment guidance. This article reviews current HF applications for all the available non-invasive imaging modalities: echocardiography, cardiovascular magnetic resonance (CMR), nuclear imaging-positron emission tomography (PET) and single-photon emission computed tomography (SPECT) and computed tomography (CT). Echocardiography, with its recent developments, such as 3D echo, is the main imaging test used in the evaluation of HF patients, given its availability and reliability in assessing cardiac structure and function. CMR allows the characterisation of myocardial tissue, in addition to providing information on the structure and cardiac function, so it is a great help in the determination of HF aetiology and may predict patient outcomes. Nuclear imaging can detect ischaemia and viability and can obtain additional prognostic data. Cardiac CT is EchocardiographyAlthough echocardiography is a relatively 'ancient' technique, its versatility makes it unique in the provision of volumes, function, haemodynamics or valvular regurgitation. In addition, because of its availability, safety and low cost, echocardiography is the first and most widely used test for the diagnosis, selection of appropriate treatment and prognosis of HF.1 Echocardiography is also the most used imaging method in the reassessment of HF patients. It remains unclear when to repeat echocardiographic exams, but it is deemed appropriate at least in patients with worsening symptoms. Systolic FunctionGlobal left ventricular (LV) function is of paramount importance regarding therapeutic decisions. Visual estimation of ejection fraction (EF), the Teichholz and Simpson methods, have been widely validated. 2,3However, in 2D imaging, because of its operator-dependent nature, repeated testing has a high probability of producing variable volume and EF results.The apparition of 3D fully sampled matrix transthoracic echocardiography has enabled easier acquisition of images, 4 simplifying its routinary application. There have been many studies comparing 2D and 3D echocardiography (2DE and 3DE) and a 'reference' standard (generally CMR). A recent meta-analysis of all 3DE studies evaluating LV volumes and EF demonstrated that 3DE generally underestimated volumes, but not as significantly as 2DE. There was also less variability than 2D compared with CMR.5 Nonetheless, 3DE echocardiography may be challenging and not practical in patients with low image quality (e.g. critical patients), in whom 2DE measures are more realiable. 3DE is also a less standardised techique than 2DE, and because of this reason most laboratories use the more universally applicable 2DE measurements in clinical practice. Only recently, large analyses of LV parameters using 3DE in large cohorts of healthy individuals have been published to establish race, age and gender-specific ...

show abstract

Cardiac Sympathetic Denervation Assessed With 123-Iodine Metaiodobenzylguanidine Imaging Predicts Ventricular Arrhythmias in Implantable Cardioverter-Defibrillator Patients

Abstract: Cardiac sympathetic denervation predicts ventricular arrhythmias causing appropriate ICD therapy as well as the composite of appropriate ICD therapy or cardiac death.

Cited by 330 publications

References 25 publications

Cardiac autonomic imaging with SPECT tracers

Cardiac autonomic imaging with SPECT tracers

Nuclear Molecular Imaging of the Failing Heart

Novel Imaging Techniques for Heart Failure

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