Cardiac tamponade as an initial manifestation of systemic lupus erythematosus in early childhood.

Gulati, Shilpa; Kumar, L

doi:10.1136/ard.51.2.279

Cited by 24 publications

(11 citation statements)

References 10 publications

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“…In studies of paediatric populations with SLE published after 1980, the incidence of pericarditis has ranged from 5-24%, and myocarditis from 2-6% 8-10. With the exception of case reports,8 11 no mention of the frequency of cardiac tamponade in childhood onset SLE has been published in the medical literature.…”

Section: Discussionmentioning

confidence: 99%

Anti-Ro/SS-A and anti-La/SS-B antibodies associated with cardiac involvement in childhood systemic lupus erythematosus

Oshiro

Derbes

Stopa

et al. 1997

Annals of the Rheumatic Diseases

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Objectives-To determine the frequency and type of cardiac manifestations in children with systemic lupus erythematosus (SLE) and investigate whether cardiac involvement of SLE in children was associated with any autoantibody pattern. Methods-Retrospective analysis of the medical records of all children with SLE (31 patients) seen between January 1984 and January 1994 by the paediatric rheumatology service at Children's Hospital in New Orleans. All patients satisfied the American College of Rheumatology criteria for the diagnosis of SLE. Paediatric SLE patients with cardiac manifestations based on echocardiogram were identified. Autoantibody tests at diagnosis were identified retrospectively by chart review, and the correlation between autoantibodies and cardiac involvement was analysed using the two tailed Fisher's exact test. Results-Thirteen (42%) of 31 SLE patients had cardiac manifestations of SLE. Seven (22%) had pericarditis without myocarditis, five (16%) had pericarditis and myocarditis, and one (3%) had myocarditis without pericarditis. Two patients (6%) with pericarditis had cardiac tamponade. Cardiac manifestations of SLE usually occurred at the time of diagnosis or within six months. Anti-Ro/SS-A antibodies were present in serum samples of nine of 11 (82%) patients with cardiac involvement and in five of 15 (33%) without cardiac involvement (p=0.02). Anti-La/SS-B antibodies were present in serum samples of six of 10 (60%) patients with cardiac involvement and two of 15 (13%) without cardiac involvement (p=0.03). Anti-Sm and anti-RNP antibodies showed no correlation with the presence of cardiac disease. Conclusions-Cardiac involvement in our paediatric SLE population was frequently found and correlated significantly with the presence of anti-Ro/SS-A and anti-La/ SS-B antibodies.

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Section: Discussionmentioning

confidence: 99%

Anti-Ro/SS-A and anti-La/SS-B antibodies associated with cardiac involvement in childhood systemic lupus erythematosus

Oshiro

Derbes

Stopa

et al. 1997

Annals of the Rheumatic Diseases

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“…Our first case received a few weeks course of antituberculosis treatment that was discontinued after the negative tuberculosis culture, case 58 had a positive antideaminase test and received a 6 months course of antituberculosis treatment while case 911 received 1 year of antituberculosis treatment until SLE diagnosis was made after recurrent episodes of pericarditis and cardiac tamponade. Those three cases reflect the importance of complete laboratory investigation of pericardial fluid to avoid any potential risk of missing tuberculosis, and at the same time the importance of screening with ANA and anti-dsDNA titres for early recognition of SLE.…”

Section: Discussionmentioning

confidence: 99%

Cardiac tamponade as the first manifestation of systemic lupus erythematosus in children: Table 1

et al. 2012

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SummarySystemic lupus erythematosus (SLE) is a serious chronic autoimmune disease with intense inflammatory response and damage in many target organs including joints, skin, kidneys, heart and nervous system. Cardiac tamponade is extremely rare as a cardinal presentation of SLE in children with only a few cases reported in the literature. We report two cases of a 9-year-old boy and an 11-year-old girl presenting with acute cardiac tamponade and later recognition of elevated anti-double-stranded DNA (anti-dsDNA) titre. We also present a literature review about similar cases in children and we stress on the importance of screening all cases of acute cardiac tamponade in children with antinuclear and anti-dsDNA antibodies to avoid any delay in SLE diagnosis and treatment. BACKGROUND

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“…À notre connaissance, seulement 25 cas de tamponnades inaugurales du LES ont été rapportés dans la littérature (tableau I). Les âges extrêmes [10,15,21,23] et la relative fréquence des sujets de sexe masculin [7,19,21,22] caractérisaient ces lupus révélés par une tamponnade, ce qui contribue encore plus à la difficulté diagnostique. L'analyse des observations rapportées (tableau I) nous a permis de noter une fréquence relativement importante des lupus induits dans ce groupe de patients (5 cas parmi les 25 ; soit une fréquence de 20 %) [3,5,6,19,21] contrastant avec une fréquence de 5 à 10 % dans les autres séries de LES [21].…”

Section: Discussionunclassified

Tamponnade révélatrice d’un lupus érythémateux systémique

et al. 2008

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Cardiac tamponade as an initial manifestation of systemic lupus erythematosus in early childhood.

Abstract: Cardiac tamponade is rare as an initial manifestation of systemic lupus erythematosus (SLE), and even more so in paediatric patients.

Cited by 24 publications

References 10 publications

Anti-Ro/SS-A and anti-La/SS-B antibodies associated with cardiac involvement in childhood systemic lupus erythematosus

Anti-Ro/SS-A and anti-La/SS-B antibodies associated with cardiac involvement in childhood systemic lupus erythematosus

Cardiac tamponade as the first manifestation of systemic lupus erythematosus in children: Table 1

Tamponnade révélatrice d’un lupus érythémateux systémique

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