Cardiac telocytes are double positive for <scp>CD</scp>34/<scp>PDGFR</scp>‐α

Zhou, Qing; Wei, Lei; Zhong, Chongjun; Fu, Siyi; Bei, Yihua; Huică, Radu‐Ionuț; Wang, Fei; Xiao, Junjie

doi:10.1111/jcmm.12615

Cited by 72 publications

(44 citation statements)

References 55 publications

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“…These cells express vimentin and CD34, with several reports that showed coexpressions with c-kit or PDGFR-β markers (94). Of note, the unique phenotype that distinguishes telocytes from other interstitial cells is the distinct and very fine cellular prolongation called telopodes.…”

Section: Cscs Relationship With Other Cellsmentioning

confidence: 64%

Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone

Leong

Ellison

et al. 2017

Front. Cardiovasc. Med.

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Heart failure is the number one killer worldwide with ~50% of patients dying within 5 years of prognosis. The discovery of stem cells, which are capable of repairing the damaged portion of the heart, has created a field of cardiac regenerative medicine, which explores various types of stem cells, either autologous or endogenous, in the hope of finding the “holy grail” stem cell candidate to slow down and reverse the disease progression. However, there are many challenges that need to be overcome in the search of such a cell candidate. The ideal cells have to survive the harsh infarcted environment, retain their phenotype upon administration, and engraft and be activated to initiate repair and regeneration in vivo. Early bench and bedside experiments mostly focused on bone marrow-derived cells; however, heart regeneration requires multiple coordinations and interactions between various cell types and the extracellular matrix to form new cardiomyocytes and vasculature. There is an observed trend that when more than one cell is coadministered and cotransplanted into infarcted animal models the degree of regeneration is enhanced, when compared to single-cell administration. This review focuses on stem cell candidates, which have also been tested in human trials, and summarizes findings that explore the interactions between various stem cells in heart regenerative therapy.

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Section: Cscs Relationship With Other Cellsmentioning

confidence: 64%

Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone

Leong

Ellison

et al. 2017

Front. Cardiovasc. Med.

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“…Although TC do not possess a unique antigenic profile, a combination of CD34 and platelet-derived growth factor receptor a (PDGFRa) is currently considered the most reliable marker for their immunohistochemical identification [12]. Indeed, coexpression of CD34 and PDGFRa has been widely observed in TC from different human organs [12,43,44]. It also appears that the TC immunophenotype may vary among systems and that different TC subtypes likely playing differential roles may coexist within the same organ [45][46][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

“…It also appears that the TC immunophenotype may vary among systems and that different TC subtypes likely playing differential roles may coexist within the same organ [45][46][47][48][49]. For instance, TC may express either CD34, PDGFRa or c-kit/CD117 in some human organs, such as the heart, while they are CD34 + /PDGFRa + and c-kit-negative in others, such as the gastrointestinal tract [25,[43][44][45]47].…”

Section: Introductionmentioning

confidence: 99%

Telocytes in normal and keratoconic human cornea: an immunohistochemical and transmission electron microscopy study

Marini

Mencucci

Rosa

et al. 2017

J Cellular Molecular Medi

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Telocytes (TC) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in the interstitium of various organs in vertebrates, including humans. However, no study has yet described the presence of TC in the human eye and in particular, within the stromal compartment of the cornea. To address this issue, samples of normal and pathologic (keratoconic) human corneas were tested by immunohistochemistry for CD34, platelet‐derived growth factor receptor α (PDGFRα) and c‐kit/CD117 or examined by transmission electron microscopy. We found that TC coexpressing CD34 and PDGFRα were distributed throughout the whole normal corneal stroma with different TC subtypes being distinguishable on the basis of the expression of the stemness marker c‐kit (i.e. c‐kit‐positive and c‐kit‐negative TC subpopulations). Transmission electron microscopy examination confirmed the existence of spindle‐shaped and bipolar TC typically displaying two long and thin moniliform telopodes establishing intercellular contacts formed by gap junctions. Keratoconic corneas were characterized by ultrastructural damages and patchy loss of TC with an almost complete depletion of the c‐kit‐positive TC subpopulation. We propose that TC may contribute to the maintenance of corneal stromal homoeostasis and that, in particular, the c‐kit‐positive TC subtype might have stemness capacity participating in corneal regeneration and repair processes. Further studies are needed to clarify the differential roles of corneal TC subtypes as well as the possible therapeutic applications of TC in degenerative corneal disorders such as keratoconus.

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“…Telocytes are likely to have a mesenchymal origin and are best characterized by very long extensions called telopodes (Tps) (for details see reviews . They were characterized in terms of ultrastructure , immunophenotype , proteomic , gene profile and miRNA imprint and shown to be different from fibroblasts, mesenchymal cells or endothelial cells. Moreover, TCs display distinct electrophysiological properties .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types

Song

Crețoiu

Zheng

et al. 2015

J Cellular Molecular Medi

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Telocytes (TCs) are new cellular entities of mesenchymal origin described almost ubiquitously in human and mammalian organs (www.telocytes.com). Different subtypes of TCs were described, all forming networks in the interstitial space by homo‐ and heterocellular junctions. Previous studies analysed the gene expression profiles of chromosomes 1, 2, 3, 17 and 18 of murine pulmonary TCs. In this study, we analysed by bioinformatics tools the gene expression profiles of chromosome 4 for murine pulmonary TCs and compared it with mesenchymal stem cells (MSCs), fibroblasts (Fbs), alveolar type II cells (ATII), airway basal cells, proximal airway cells, CD8(+) T cells from bronchial lymph nodes (T‐BL) and CD8(+) T cells from lungs (T‐L). Key functional genes were identified with the aid of the reference library of the National Center for Biotechnology Information Gene Expression Omnibus database. Seventeen genes were up‐regulated and 56 genes were down‐regulated in chromosome 4 of TCs compared with other cells. Four genes (Akap2, Gpr153, Sdc3 and Tbc1d2) were up‐regulated between one and fourfold and one gene, Svep1, was overexpressed over fourfold. The main functional networks were identified and analysed, pointing out to a TCs involvement in cellular signalling, regulation of tissue inflammation and cell expansion and movement.

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Cardiac telocytes are double positive for CD34/PDGFR‐α

Cited by 72 publications

References 55 publications

Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone

Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone

Telocytes in normal and keratoconic human cornea: an immunohistochemical and transmission electron microscopy study

Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types

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