Cardiac Tissue Engineering

Lee, Eun Jung; Hitscherich, Pamela

doi:10.1002/9783527689934.ch13

Cited by 3 publications

(7 citation statements)

References 217 publications

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“…Improved cell retention, survival, and integrity are guided by precultivation. 82 , 84 , 85 , 86 , 87…”

Section: Cardiac Tissue Regenerationmentioning

confidence: 99%

“…Accurate control of cell differentiation or conversion, teratocarcinogenicity, and concerns associated with allogenic sources are formidable limitations. 35,82 F I G U R E 2 Cardiac tissue engineering strategies. Cells, scaffolds, and signaling molecules can be introduced alone or in combination at the injury site.…”

Section: Cardiac Tissue Regenerationmentioning

confidence: 99%

“…Stem and precursor cells favor sources and differentiated cells, yet there are various particular challenges to overcome. Accurate control of cell differentiation or conversion, teratocarcinogenicity, and concerns associated with allogenic sources are formidable limitations 35,82 . Efficient recruitment of appropriate cell types and selecting a proper substrate to enhance cell retention and integration, as a result, is highly pivotal.…”

Section: Cardiac Tissue Regenerationmentioning

confidence: 99%

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Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

Jalilinejad

Rabiee

Baheiraei

et al. 2022

Bioengineering & Transla Med

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A proper self‐regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon‐based nanomaterials because of their exceptional variable functionality, conductivity, and mechanical properties. Electrically conductive biomaterials used as cell bearers provide the tissue with an appropriate microenvironment for the specific seeded cells as substrates for the sake of protecting cells in biological media against attacking mechanisms. Nevertheless, their advantages and shortcoming in view of cellular behavior, toxicity, and targeted delivery depend on the tissue in which they are implanted or being used as a scaffold. This review seeks to address, summarize, classify, conceptualize, and discuss the use of carbon‐based nanoparticles in cardiac tissue engineering emphasizing their conductivity. We considered electrical conductivity as a key affecting the regeneration of cells. Correspondingly, we reviewed conductive polymers used in tissue engineering and specifically in cardiac repair as key biomaterials with high efficiency. We comprehensively classified and discussed the advantages of using conductive biomaterials in cardiac tissue engineering. An overall review of the open literature on electroactive substrates including carbon‐based biomaterials over the last decade was provided, tabulated, and thoroughly discussed. The most commonly used conductive substrates comprising graphene, graphene oxide, carbon nanotubes, and carbon nanofibers in cardiac repair were studied.

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“…Improved cell retention, survival, and integrity are guided by precultivation. 82 , 84 , 85 , 86 , 87…”

Section: Cardiac Tissue Regenerationmentioning

confidence: 99%

Section: Cardiac Tissue Regenerationmentioning

confidence: 99%

Section: Cardiac Tissue Regenerationmentioning

confidence: 99%

See 1 more Smart Citation

Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

Jalilinejad

Rabiee

Baheiraei

et al. 2022

Bioengineering & Transla Med

View full text Add to dashboard Cite

show abstract

“…As they are permanently beating, a constantly high intake of nutrients and oxygen is required to meet their metabolic needs. These nutrients and oxygen are supplied by a dense and very wellorganized vascular network, in which smooth muscle cells and endothelial cells are the main cell sources that form and maintain the vascular network (Eng et al, 2016).…”

Section: Cardiac Muscle Regeneration and Angiogenesismentioning

confidence: 99%

Elastin-Based Materials: Promising Candidates for Cardiac Tissue Regeneration

Torre

Alonso

Rodríguez-Cabello

2020

Front. Bioeng. Biotechnol.

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Stroke and cardiovascular episodes are still some of the most common diseases worldwide, causing millions of deaths and costing billions of Euros to healthcare systems. The use of new biomaterials with enhanced biological and physical properties has opened the door to new approaches in cardiovascular applications. Elastin-based materials are biomaterials with some of the most promising properties. Indeed, these biomaterials have started to yield good results in cardiovascular and angiogenesis applications. In this review, we explore the latest trends in elastin-derived materials for cardiac regeneration and the different possibilities that are being explored by researchers to regenerate an infarcted muscle and restore its normal function. Elastin-based materials can be processed in different manners to create injectable systems or hydrogel scaffolds that can be applied by simple injection or as patches to cover the damaged area and regenerate it. Such materials have been applied to directly regenerate the damaged cardiac muscle and to create complex structures, such as heart valves or new bio-stents that could help to restore the normal function of the heart or to minimize damage after a stroke. We will discuss the possibilities that elastin-based materials offer in cardiac tissue engineering, either alone or in combination with other biomaterials, in order to illustrate the wide range of options that are being explored. Moreover, although tremendous advances have been achieved with such elastin-based materials, there is still room for new approaches that could trigger advances in cardiac tissue regeneration.

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“…Research in this area began with the idea of replacing or replenishing the lost cardiomyocytes because adult cardiomyocytes do not readily proliferate. Various cell sources were explored from transdifferentiated fibroblasts to stem cell derived populations ( 7 ), including placental derived cells such as amniotic epithelial ( 8 – 10 ) and stromal cells ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Human Placental Allograft Membranes: Promising Role in Cardiac Surgery and Repair

Hitscherich

Chnari

Deckwa

et al. 2022

Front. Cardiovasc. Med.

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Despite the immense investment in research devoted to cardiovascular diseases, mechanisms of progression and potential treatments, it remains one of the leading causes of death in the world. Cellular based strategies have been explored for decades, having mixed results, while more recently inflammation and its role in healing, regeneration and disease progression has taken center stage. Placental membranes are immune privileged tissues whose native function is acting as a protective barrier during fetal development, a state which fosters regeneration and healing. Their unique properties stem from a complex composition of extracellular matrix, growth factors and cytokines involved in cellular growth, survival, and inflammation modulation. Placental allograft membranes have been used successfully in complex wound applications but their potential in cardiac wounds has only begun to be explored. Although limited, pre-clinical studies demonstrated benefits when using placental membranes compared to other standard of care options for pericardial repair or infarct wound covering, facilitating cardiomyogenesis of stem cell populations in vitro and supporting functional performance in vivo. Early clinical evidence also suggested use of placental allograft membranes as a cardiac wound covering with the potential to mitigate the predominantly inflammatory environment such as pericarditis and prevention of new onset post-operative atrial fibrillation. Together, these studies demonstrate the promising translational potential of placental allograft membranes as post-surgical cardiac wound coverings. However, the small number of publications on this topic highlights the need for further studies to better understand how to support the safe and efficient use of placenta allograft membranes in cardiac surgery.

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Cardiac Tissue Engineering

Cited by 3 publications

References 217 publications

Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

Elastin-Based Materials: Promising Candidates for Cardiac Tissue Regeneration

Human Placental Allograft Membranes: Promising Role in Cardiac Surgery and Repair

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