Cardio-vaskuläres System

Steding, Gerd; Seidl, W; Christ, Bodo

doi:10.1007/978-3-662-07815-0_10

Cited by 11 publications

(17 citation statements)

References 164 publications

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“…Changing flow patterns have been documented by microcinematography during development ( Fig. 8) (292,293). Watching a beating embryonic heart during an early stage of development gives the impression that two separate bloodstreams flow through the heart tube (344), because contraction is not circular but asymmetric.…”

Section: B Cardiac Looping Changing Blood Flows and Chamber Formationmentioning

confidence: 96%

“…The conversion of such a serial arrangement of segments into the proper parallel arrangement has remained one of the most difficult concepts of heart development (156), for it seems illogical first to make a serial arrangement of cardiac segments and then a parallel one. Based on morphological and flow direction considerations, Steding and Seidl (292) described this concept as "one of the most fatal assumptions." Recent functional and molecular data also challenged the concept (51,64,118,210), and a new concept was formulated, "the ballooning model of chamber formation."…”

Section: A Scopementioning

confidence: 99%

“…The blood-flow pattern changes from an initially right flow at the inner curvature and an initially left flow at the outer curvature to the adult configuration, with the left flow directed toward the inner curvature ( Fig. 8) (292).…”

Section: B Cardiac Looping Changing Blood Flows and Chamber Formationmentioning

confidence: 99%

See 2 more Smart Citations

Cardiac Chamber Formation: Development, Genes, and Evolution

Moorman

Christoffels

2003

Physiological Reviews

650

526

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Moorman, Antoon F. M., and Vincent M. Christoffels. Cardiac Chamber Formation: Development, Genes, and Evolution. Physiol Rev 83: 1223-1267, 2003; 10.1152/physrev.00006.2003.—Concepts of cardiac development have greatly influenced the description of the formation of the four-chambered vertebrate heart. Traditionally, the embryonic tubular heart is considered to be a composite of serially arranged segments representing adult cardiac compartments. Conversion of such a serial arrangement into the parallel arrangement of the mammalian heart is difficult to understand. Logical integration of the development of the cardiac conduction system into the serial concept has remained puzzling as well. Therefore, the current description needed reconsideration, and we decided to evaluate the essentialities of cardiac design, its evolutionary and embryonic development, and the molecular pathways recruited to make the four-chambered mammalian heart. The three principal notions taken into consideration are as follows. 1) Both the ancestor chordate heart and the embryonic tubular heart of higher vertebrates consist of poorly developed and poorly coupled “pacemaker-like” cardiac muscle cells with the highest pacemaker activity at the venous pole, causing unidirectional peristaltic contraction waves. 2) From this heart tube, ventricular chambers differentiate ventrally and atrial chambers dorsally. The developing chambers display high proliferative activity and consist of structurally well-developed and well-coupled muscle cells with low pacemaker activity, which permits fast conduction of the impulse and efficacious contraction. The forming chambers remain flanked by slowly proliferating pacemaker-like myocardium that is temporally prevented from differentiating into chamber myocardium. 3) The trabecular myocardium proliferates slowly, consists of structurally poorly developed, but well-coupled, cells and contributes to the ventricular conduction system. The atrial and ventricular chambers of the formed heart are activated and interconnected by derivatives of embryonic myocardium. The topographical arrangement of the distinct cardiac muscle cells in the forming heart explains the embryonic electrocardiogram (ECG), does not require the invention of nodes, and allows a logical transition from a peristaltic tubular heart to a synchronously contracting four-chambered heart. This view on the development of cardiac design unfolds fascinating possibilities for future research.

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Section: B Cardiac Looping Changing Blood Flows and Chamber Formationmentioning

confidence: 96%

Section: A Scopementioning

confidence: 99%

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Cardiac Chamber Formation: Development, Genes, and Evolution

Moorman

Christoffels

2003

Physiological Reviews

650

526

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“…It is roughly triangular and its margins are described as antero-superior, inferior and septal corresponding to the lines of attachment of the valvular leaflets [8]. The atrio-ventricular valve develops from the excavation of the supporting ventricular myocardium (Steding and Seidl, 1993) [10]. The edges and ventricular surfaces of the cusps receives the attachment of chordae tendineae, collagenous cords, which diverge from the papillary muscles and prevent the cusps from being everted, when the ventricle contracts.…”

Section: Introductionmentioning

confidence: 99%

Morphological Study of Tricuspid Valve And Its Variations in Adult Human Hearts.

Kujur¹,

Thakur²,

Prasad³

2016

IOSR

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“…3a). Multifocal disorders in the normal process of obliteration and septation within this pharyngeal artery system at the 8-to 13-mm stage (37th to 44th day of gestation) seem to be responsible for the morphogenesis of the reported malformations [14]. Instead of the right dorsal aorta the left one regressed distal of the origin of the subclavian artery ( fig.…”

Section: Discussionmentioning

confidence: 92%

Pulmonary Atresia with Hypoplastic Right Ventricle

Fröber¹,

Kohoutek

Kähler

et al. 2001

Fetal Diagn Ther

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An unusual case of pulmonary atresia with an aberrant karyotype of 46,XX,t(6;8)(p21.2;q11.2) is reported. Fetal ultrasonic examination at the 20th week of gestation revealed a hypoplastic right ventricle and an intact interventricular septum. Authors summarize their postnatal findings in fetal heart and the large adjacent vessels with special reference to the pathogenesis of this rare congenital heart defect. The observation delineates right-ventricular outflow tract obstruction associated with an abnormal pulmonary blood supply. The anatomy of the systemic pulmonary collaterals was studied and correlated with multifocal disorders in the system of the pharyngeal arch arteries in the early embryonic development.

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Cardio-vaskuläres System

Cited by 11 publications

References 164 publications

Cardiac Chamber Formation: Development, Genes, and Evolution

Cardiac Chamber Formation: Development, Genes, and Evolution

Morphological Study of Tricuspid Valve And Its Variations in Adult Human Hearts.

Pulmonary Atresia with Hypoplastic Right Ventricle

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