Cardiometabolic Differences in Children Born After in Vitro Fertilization: Follow-Up Study

Ceelen, Manon; Weissenbruch, Mirjam M. van; Vermeiden, Jan P.W.; Leeuwen, Flora E. van; Waal, Henriëtte A. Delemarre-van de

doi:10.1210/jc.2007-2432

Cited by 368 publications

(285 citation statements)

References 26 publications

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“…Generally the data are ressuring, nevertheless a small but consistent increase in blood pressure of ART-children compared to children born after spontaneous conceptions has been found [78,79]. This in contrast to a recent study from Belgium that failed to confirm the difference in ICSI children [80].…”

Section: Norwegian Data On Art Children and Their Siblingsmentioning

confidence: 56%

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Albertini

Evers²,

Geraedts³

et al. 2014

J Assist Reprod Genet

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Purpose Assisted Reproduction Treatment (ART) is here to stay. This review addresses the parental background of birth defects, before, during and after conception and focuses both on the underlying subfertility and on the question whether ART as a treatment is an additional contributing factor. Methods Searches were performed in Medline and other databases. Summaries were discussed in a Delphi panel set-up by the European Society of Human Reproduction and Embryology (ESHRE). Results Several birth defects and adult diseases arise during the earliest stages of ovarian development and oocyte differentiation: this is the case of cleft palate disorders in offspring from female rat exposed to Dioxin during fetal life or the polycystic ovary diseases in female offspring (primates) exposed to elevated androgen concentration during fetal life. Human oocytes and embryos often fail to stop the propagation of aneuploid cells but maintain their ability to repair DNA damages including those introduced by the fertilizing sperm. There is a 29 % increased risk of birth defects in the newborns spontaneously conceived by subfertile couples and the risk is further increased (34 %) when conception is achieved by treating infertlity with ART (Danish IVF Registry). Periconceptional conditions are critical for ART babies: their birth weight is in general smaller (Norvegian Registry) but a more prolonged culture time doubled the number of large babies (Finnish Registry). Conclusion The long-term developmental effects of ART on child and subsequent health as an adult remains a subject worthy of futher monitoring and investigation. Capsule Remaining mindful of the growing body of evidence showing that during gamete production, genetic and epigenetic changes influence offspring health, serves to reinforce the need to continue to monitor ART children.

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Section: Norwegian Data On Art Children and Their Siblingsmentioning

confidence: 56%

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Albertini

Evers²,

Geraedts³

et al. 2014

J Assist Reprod Genet

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“…Никаких разли-чий между этими двумя группами обнаружено не было [9]. Тем не менее у детей, зачатых с помощью ЭКО, выявлены более высокие цифры артериально-го давления и уровня глюкозы в крови по сравнению с той же возрастной группой (8-18 лет) из общей по-пуляции [10,11]. Также зафиксирована предраспо-ложенность к ожирению у детей, зачатых c помощью метода ИКСИ [4].…”

Section: заболеваемость раком после экоunclassified

Neonatal outcome after IVF

Sazonova¹

2016

Probl. reprod.

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“…For example, 22.5% of women report an episode of drinking during the first month of gestation but not later in pregnancy (Ethen et al 2009), whilst many women alter their diet or begin taking dietary supplements when knowingly pregnant (Elmadfa & Meyer 2012). Studies into long-term health of babies from assisted reproductive technologies have shown that children born following IVF have higher systolic and diastolic blood pressure, as well as higher fasting blood glucose levels (Ceelen et al 2008). This suggests that manipulation of the embryo around the time of conception can alter development and can have long-lasting effects.…”

Section: Human Periconceptional Exposuresmentioning

confidence: 99%

Adverse prenatal environment and kidney development: implications for programing of adult disease

Dorey¹,

Pantaleon²,

Weir³

2014

Reproduction

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The 'developmental origins of health and disease' hypothesis suggests that many adult-onset diseases can be attributed to altered growth and development during early life. Perturbations during gestation can be detrimental and lead to an increased risk of developing renal, cardiovascular, metabolic, and neurocognitive dysfunction in adulthood. The kidney has emerged as being especially vulnerable to insult at almost any stage of development resulting in a reduction in nephron endowment. In both humans and animal models, a reduction in nephron endowment is strongly associated with an increased risk of hypertension. The focus of this review is twofold: i) to determine the importance of specific periods during development on long-term programing and ii) to examine the effects of maternal perturbations on the developing kidney and how this may program adult-onset disease. Recent evidence has suggested that insults occurring around the time of conception also have the capacity to influence long-term health. Although epigenetic mechanisms are implicated in mediating these outcomes, it is unclear as to how these may impact on kidney development. This presents exciting new challenges and areas for research.Reproduction (2014) 147 R189-R198

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Cardiometabolic Differences in Children Born After in Vitro Fertilization: Follow-Up Study

Abstract: These findings highlight the importance of continued cardiometabolic monitoring of IVF-conceived children and might contribute to current knowledge about periconceptional influences and their consequences in later life.

Cited by 368 publications

References 26 publications

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Neonatal outcome after IVF

Adverse prenatal environment and kidney development: implications for programing of adult disease

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