Cardiometabolic Risk Phenotypes and Chronic Kidney Disease Incidence in Older Adults：A Nationwide Longitudinal Cohort Study

Abstract

Background There is mixed evidence for an association between cardiometabolic risk factors and chronic kidney disease risk (CKD). This study aimed to determine whether different latent classes of cardiometabolic conditions were associated with chronic kidney disease risk. Method Data from 7,195 participants in the China Health and Retirement Longitudinal Study (CHARLS) were analyzed. Latent class analysis was performed using data on obesity, high-density lipoprotein cholesterol, triglyceride, hypertension, diabetes, arthritis or rheumatism, and systemic inflammatory conditions and heart disease. Confounder-adjusted multiple logistic regressions were conducted to estimate CKD incidence by cardiometabolic latent classes. Results Three cardiometabolic classes were identified: relatively healthy cardiometabolic (RHC) phenotype, metabolic syndrome (MetS) phenotype, and cardiovascular disease (CVD) phenotype, which accounted for 66.2%, 19.9%, and 13.8%, respectively. The incidence of CKD was 12.7% in the CVD group, 9.4% in the MetS group, and 5.9% in the RHC group. After adjusting for confounding factors, it was found that the metabolic syndrome type had a 54% increased risk of newly diagnosed CKD compared to the healthy heart type (OR = 1.54, 95% CI: 1.22–1.93), while the cardiovascular type increased by 104% (OR = 2.04, 95% CI: 1.61–2.57). Conclusion Different cardiometabolic phenotypes are associated with an increased risk of new-onset CKD. Gender and age are important factors influencing the strength of this association.