Cardioplegic solution: A contamination crisis

Hughes, Clifford F.; Grant, A. F.; Leckie, Bruce; Baird, D. K.

doi:10.1016/s0022-5223(19)36095-7

Cited by 22 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in Japan, it is reported that 60.8% of hospitals have never prepared TPN solutions under aseptic conditions, and 76.5% of hospitals have never prepared PPN solutions under aseptic conditions 9 . Contamination of the environment has been reported as the cause of nosocomial infections 10 - 13 . It is clear that the environment of preparation for infusion fluids is highly associated with bacterial contamination in infusions.…”

Section: Introductionmentioning

confidence: 99%

Water Soluble Vitamins Enhance the Growth of Microorganisms in Peripheral Parenteral Nutrition Solutions

et al. 2017

View full text Add to dashboard Cite

Peripheral parenteral nutrition (PPN) solutions contain amino acids, glucose, and electrolytes, with or without some water soluble vitamins. Peripheral venous catheters are one of the causes of catheter related blood stream infection (CRBSI), which requires infection control. In Japan, PPN solutions have rarely been prepared under aseptic conditions. However, in recent years, the necessity of adding vitamins to infusions has been reported. Therefore, we investigated the effects of water soluble vitamins on growth of microorganisms in PPN solutions. AMINOFLUID® (AF), BFLUID® (BF), PARESAFE® (PS) and PAREPLUS® (PP) PPN solutions were used. Water soluble vitamins contained in PP were also used. Causative microorganisms of CRBSI were used. Staphylococcus epidermidis decreased after 24 hours or 48 hours in all solutions. On the other hand, Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans increased, especially in PP. When each water soluble vitamin was added to BF and PS, growth of S. aureus was greater in solutions that contained nicotinamide than in solutions that contained other vitamins. As for C. albicans, they grew in all test solutions. C. albicans grew especially well in solutions that contained biotin. When commercial amino acids and glucose solutions with electrolytes are administered, in particular those containing multivitamins or water soluble vitamins, efforts to control infection must be taken to prevent proliferation of microorganisms.

show abstract

Section: Introductionmentioning

confidence: 99%

Water Soluble Vitamins Enhance the Growth of Microorganisms in Peripheral Parenteral Nutrition Solutions

et al. 2017

View full text Add to dashboard Cite

show abstract

“…9 There have been numerous reports of patient morbidity and mortality associated with contaminated compounded cardioplegia solutions. 10,11…”

Section: History Of Pharmacy Compoundingmentioning

confidence: 99%

Improving the Quality of Compounded Sterile Drug Products: A Historical Perspective

Cantrell

2016

Ther Innov Regul Sci

View full text Add to dashboard Cite

The term compounding generally refers to the practice of combining, mixing, or altering ingredients of a drug product to create a medication tailored to the needs of an individual patient. Compounding has long been a common activity within the practice of pharmacy. The scope of pharmacy compounding includes the compounding of sterile products, a practice that is especially prevalent within hospitals, home infusion pharmacies, and, more recently, outsourced compounding facilities. Reports of patient morbidity and mortality associated with compounded products have led many over the years, including the US Food and Drug Administration (FDA), to call for more stringent federal oversight of pharmacy compounding to ensure patient safety. A tipping point was reached in 2012 with the emergence of a multistate outbreak of fungal meningitis and other infections in patients who received contaminated steroid injections compounded by the New England Compounding Center in Framingham, Massachusetts. This article describes the history of the practice and regulation of pharmacy compounding, culminating in the passage by Congress of the Compounding Quality Act of 2014.

show abstract

“…In 1977, drug-related hospital deaths were documented to occur in 1.2 per 1000 patients, some of them from LVISs. 99 In 1986, 5 deaths occurred as a result of contaminated cardioplegia solutions 100 ; the source of the contamination was unclear.…”

Section: Morbidity and Mortality From Contaminated Preparationsmentioning

confidence: 99%

History of sterile compounding in U.S. hospitals: Learning from the tragic lessons of the past

Myers

2013

American Journal of Health-System Pharmacy

View full text Add to dashboard Cite

Over the years, there have been numerous exhortations for voluntary better performance in sterile compounding. In addition, professional leadership has been vigorous and extensive in the form of guidance, publications, education, enforceable standards, and development of various associations and organizations dealing with safe compounding practices. Yet problems continue to occur. We must engage in diligent learning from the injuries and tragedies that have occurred. Assuming that we are already doing all we can to avoid problems would be an abdication of the professional mission of pharmacists. It would be wrong thinking to assume that the recent problems in large-scale compounding pharmacies are the only problems that warrant attention. It is time for a systematic assessment of the nature and the dimensions of the problems in every type of setting where sterile compounding occurs. It also is time for some innovative thinking about ensuring safety in sterile compounding.

show abstract

Cardioplegic solution: A contamination crisis

Cited by 22 publications

References 10 publications

Water Soluble Vitamins Enhance the Growth of Microorganisms in Peripheral Parenteral Nutrition Solutions

Water Soluble Vitamins Enhance the Growth of Microorganisms in Peripheral Parenteral Nutrition Solutions

Improving the Quality of Compounded Sterile Drug Products: A Historical Perspective

History of sterile compounding in U.S. hospitals: Learning from the tragic lessons of the past

Contact Info

Product

Resources

About