Cardioprotection by Adiponectin

Ouchi, Noriyuki; Shibata, Rei; Walsh, Kenneth

doi:10.1016/j.tcm.2006.03.001

Cited by 225 publications

(179 citation statements)

References 86 publications

Supporting

Mentioning

162

Contrasting

Unclassified

Order By: Relevance

“…Numerous epidemiological studies have demonstrated the correlation between reduced APN levels and increased risk of cardiovascular disease in obese and diabetic individuals (1,19). APN deficiency is an independent risk factor for endothelial dysfunction, hypertension, coronary heart disease, myocardial infarction, and other cardiovascular complications (13).…”

mentioning

confidence: 99%

Reduced Cardioprotective Action of Adiponectin in High-Fat Diet–Induced Type II Diabetic Mice and Its Underlying Mechanisms

Sun

Gao

et al. 2011

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Diabetes exacerbates ischemic heart disease morbidity and mortality via incompletely understood mechanisms. Although adiponectin (APN) reduces myocardial ischemia/reperfusion (MI/R) injury in nondiabetic animals, whether APN's cardioprotective actions are altered in diabetes, a pathologic condition with endogenously reduced APN, has never been investigated. High-fat diet (HD)-induced diabetic mice and normal diet (ND) controls were subjected to MI via coronary artery ligation, and given vehicle or APN globular domain (gAPN, 2 mg/g) 10 min before reperfusion. Compared to ND mice (where gAPN exerted pronounced cardioprotection), HD mice manifested greater MI/R injury, and a tripled gAPN dose was requisite to achieve cardioprotective extent seen in ND mice (i.e., infarct size, apoptosis, and cardiac function). APN reduces MI/R injury via AMPactivated protein kinase (AMPK)-dependent metabolic regulation and AMPK-independent antioxidative/ antinitrative pathways. Compared to ND, HD mice manifested significantly blunted gAPN-induced AMPK activation, basally and after MI/R ( p < 0.05). Although both low-and high-dose gAPN equally attenuated MI/ R-induced oxidative stress (i.e., NADPH oxidase expression and superoxide production) and nitrative stress (i.e., inducible nitric oxide synthase expression, nitric oxide production, and peroxynitrite formation) in ND mice, only high-dose gAPN efficaciously did so in HD mice. We demonstrate for the first time that HD-induced diabetes diminished both AMPK-dependent and AMPK-independent APN cardioprotection, suggesting an unreported diabetic heart APN resistance. Antioxid. Redox Signal. 15, 1779-1788.

show abstract

mentioning

confidence: 99%

Reduced Cardioprotective Action of Adiponectin in High-Fat Diet–Induced Type II Diabetic Mice and Its Underlying Mechanisms

Sun

Gao

et al. 2011

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

show abstract

“…Many recent findings have suggested that adiponectin is able to influence cardiac remodeling in pathologic states, limiting the progression of myocardial hypertrophy (75). Other beneficial effects of adiponectin at the cardiac level are the protective actions against myocardial ischemiareperfusion (75) and the protection against the development of systolic dysfunction after myocardial infarction observed in mice (76).…”

Section: Adiponectinmentioning

confidence: 99%

Cardiometabolic comorbidities and rheumatic diseases: Focus on the role of fat mass and adipokines

Lago¹,

Gómez²,

Conde³

et al. 2011

Arthritis Care & Research

View full text Add to dashboard Cite

“…Adiponectin is a hormone produced by the white adipose tissue and is released directly into the blood, where its levels are within the range 0.5-30 μg/mL with a total concentration of 0.01% of the total plasma proteins [1]. It belongs to the same group of adipokines as leptin, TNF-α, plasminogen activator inhibitor, adipsin and resistin [2]. It is a collagen-like protein, which shows similarities with collagen type VIII and X [1].…”

Section: Introductionmentioning

confidence: 99%

Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep

Podlaha

Schwanhaeuser

2014

Acta Veterinaria

View full text Add to dashboard Cite

Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before fi nishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after extirpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confi rmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that Adipograft Ra 1vk 7/350 can be a turning point in the development of vascular prostheses, due to its patency and quick healing.

show abstract

Cardioprotection by Adiponectin

Cited by 225 publications

References 86 publications

Reduced Cardioprotective Action of Adiponectin in High-Fat Diet–Induced Type II Diabetic Mice and Its Underlying Mechanisms

Reduced Cardioprotective Action of Adiponectin in High-Fat Diet–Induced Type II Diabetic Mice and Its Underlying Mechanisms

Cardiometabolic comorbidities and rheumatic diseases: Focus on the role of fat mass and adipokines

Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep

Contact Info

Product

Resources

About