Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation

Cardio Protective Effects of Hydroalcholic Citrus Aurantium Extract on Myocardial Infarction Induced by Isoproterenol in Male Rats

“…A considerable rise in the total cholesterol and triglycerides was detected in serum of ISO treated rats, which is in line with previous reports [15,19]. Rats treated with ISO also exhibited an increase in LDL fraction along with a decline in HDL cholesterol.…”

“…Twenty four normal adult male Wistar albino rats weighting 200-250 g were selected and kept in single cages in standard laboratory settings (temperature 23 ± 2 0 C, 12 h light and dark cycle, and 35-60% humidity) for one week for adaptation [14,15]. Animals were fed with standard pellet diet and water ad libitum.…”

“…At the end of the experimental duration, needle electrodes were implanted under the skin of animals in lead II position [15], under anesthesia with ketamine and xylazine (80 and 20 mg/kg) intrapritoneally. ECG recordings obtained through computerized Power Lab system (AD Instruments, Australia) and analyzed with chart7 software.…”

Tomato lycopene attenuates myocardial infarction induced by isoproterenol: Electrocardiographic, biochemical and anti–apoptotic study

“…High dose of isoproterenol (ISO), a 毬 -adrenergic agonist, has been reported to induce MI in experimental animals which is confirmed by hyperglycemia, hyperlipidemia, increase in cardiac marker enzymes, hemodynamic changes, biochemical alterations and generation of oxidative stress [3][4][5] .…”

Effects of acute pre-treatment with ethanolamine on isoprenalineinduced myocardial infarction in adult Wistar rats

“…Contrary to several previous studies, our data suggest that ISO did not increase oxidative stress. Karthikeyan, et al, (34) Patel, et al, (35) and Mukherjee, et al (36) reported that ISO causes an increase in oxidative stress markers. However, there were several critical differences between these studies and the current study: (1) animals in the previous studies received repeated doses of ISO, as compared to the single dose administered in the current study, (2) measures of lipid peroxidation and oxidative stress were measured two or more days after the initial dose of ISO, as compared to 24 hours after the initial dose in the current study, (3) all 3 of these studies analysed homogenised myocardium, not circulating plasma.…”